Carolyn F. Deacon
Carolyn F. Deacon

Associate Professor


  1. Published

    Paracrine Crosstalk between Intestinal L- and D-cells Controls Secretion of Glucagon-Like Peptide-1 in mice

    Jepsen, Sara Lind, Grunddal, Kaare Villum, Albrechtsen, Nicolai Jacob Wewer, Engelstoft, M. S., Gabe, Maria Buur Nordskov, Jensen, E. P., Ørskov, Cathrine, Poulsen, Steen Seier, Rosenkilde, M. M., Pedersen, J., Gribble, F. M., Reimann, F., Deacon, Carolyn F., Schwartz, Thue W., Christ, A. D., Martin, R. E. & Holst, Jens Juul, 2019, In : American Journal of Physiology: Endocrinology and Metabolism. 317, 6, p. E1081-E1093

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Peptide degradation and the role of DPP-4 inhibitors in the treatment of type 2 diabetes

    Deacon, Carolyn F., Feb 2018, In : Peptides. 100, p. 150-157 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Peptide production and secretion in GLUTag, NCI-H716 and STC-1 cells: a comparison to native L-cells.

    Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Deacon, Carolyn F., Balk-Møller, E., Rehfeld, Jens Frederik, Relman, F., Gribble, F. M. & Holst, Jens Juul, 2016, In : Journal of Molecular Endocrinology. 56, p. 201-211

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Pharmacodynamics of vildagliptin in patients with type 2 diabetes during OGTT.

    He, Y., Wang, Y., Bullock, J. M., Deacon, Carolyn F., Holst, Jens Juul, Dunning, B. E., Ligueros-Saylan, M. & Foley, J. E., 2007, In : Journal of Clinical Pharmacology. 47, 5, p. 633-41 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Pharmacokinetics and pharmacodynamics of vildagliptin in patients with type 2 diabetes mellitus.

    He, Y., Serra, D., Wang, Y., Campestrini, J., Riviere, G., Deacon, Carolyn F., Holst, Jens Juul, Schwartz, S., Nielsen, J. C. & Ligueros-Saylan, M., 2007, In : Clinical Pharmacokinetics. 46, 7, p. 577-88 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Physiology and Pharmacology of DPP-4 in Glucose Homeostasis and the Treatment of Type 2 Diabetes

    Deacon, Carolyn F., 2019, In : Frontiers in Endocrinology. 10, 14 p., 80.

    Research output: Contribution to journalReviewResearchpeer-review

  7. Published

    Physiology of incretins in health and disease

    Deacon, Carolyn F. & Ahren, B., 2011, In : Review of Diabetic Studies. 8, 3, p. 293-306 14 p.

    Research output: Contribution to journalReviewResearchpeer-review

  8. Published

    Physiology of the Incretin Hormones, GIP and GLP-1-Regulation of Release and Posttranslational Modifications

    Holst, Jens Juul, Albrechtsen, Nicolai Jacob Wewer, Rosenkilde, Mette & Deacon, Carolyn F., 2019, In : Comprehensive Physiology. 9, 4, p. 1339-1381

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Plasma TNF-x is associated with insulin mediated suppression of free fatty acids and net lipid oxidation in HIV-infected patients with lipodystrophy

    Haugaard, S. B., Andersen, O., Pedersen, S. B., Dela, Flemming & Deacon, Carolyn F., 1996, In : Metabolism - Clinical and Experimental. 55(2), p. 175-182

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Plasma dipeptidyl peptidase-IV activity in patients with type-2 diabetes mellitus correlates positively with HbAlc levels, but is not acutely affected by food intake

    Ryskjaer, J., Deacon, Carolyn F., Carr, R. D., Krarup, T., Madsbad, Sten, Holst, Jens Juul, Vilsbøll, Tina, Ryskjaer, J., Deacon, C. F., Carr, R. D., Krarup, T., Madsbad, Sten, Holst, J. J. & Vilsbøll, T., 1 Sep 2006, In : European Journal of Endocrinology. 155, 3, p. 485-93 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Posttranslational processing of proglucagon and postsecretory fate of proglucagon products.

    Holst, Jens Juul, Ørskov, C., Hartmann, B. & Deacon, Carolyn F., 1997, The Insulinotropic Gut Hormone Glucagon-like Peptide-1.. Basel: Karger, p. 24-48

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  12. Published

    Potential cardiovascular effects of incretin-based therapies

    Deacon, Carolyn F. & Marx, N., 2012, In : Expert Review of Cardiovascular Therapy. 10, p. 337-351

    Research output: Contribution to journalReviewResearchpeer-review

  13. Published

    Potential of liraglutide in the treatment of patients with type 2 diabetes

    Deacon, Carolyn F., 2009, In : Vascular Health and Risk Management (Online). 5, 1, p. 199-211 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Preservation of active incretin hormones by inhibition of dipeptidyl peptidase IV suppresses meal-induced incretin secretion in dogs

    Deacon, Carolyn F., Wamberg, S., Bie, P., Hughes, T. E. & Holst, Jens Juul, Feb 2002, In : Journal of Endocrinology. 172, 2, p. 355-62 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Preserved inhibitory potency of GLP-1 on glucagon secretion in type 2 diabetes mellitus

    Hare, K. J., Knop, Filip Krag, Asmar, M., Madsbad, Sten, Deacon, Carolyn F., Holst, Jens Juul & Vilsbøll, Tina, 2009, In : Journal of Clinical Endocrinology and Metabolism. 94, 12, p. 4679-87 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Quantification of the contribution of GLP-1 to mediating insulinotropic effects of DPP-4 inhibition with vildagliptin in healthy subjects and type 2-diabetic patients using exendin [9-39] as a GLP-1 receptor antagonist.

    Nauck, M. A., Kind, J., Köthe, L. D., Holst, Jens Juul, Deacon, Carolyn F., Broschag, M., He, Y., Kjems, L. & Foley, J., 2016, In : Diabetes. 65, 8, p. 2440-2447 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes

    Meier, J. J., Huking, K., Holst, Jens Juul, Deacon, Carolyn F., Schmiegel, W. H. & Nauck, M. A., 2001, In : Diabetes. 50, p. 2497-2504

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Restoration of the insulinotropic effect of glucose-dependent insulinotropic polypeptide contributes to the antidiabetic effect of dipeptidyl peptidase-4 inhibitors

    Aaboe, K., Akram, S., Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten & Krarup, T., Jan 2015, In : Diabetes, Obesity and Metabolism. 17, 1, p. 74-81 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Reversible hyperinsulinemic hypoglycemia after gastric bypass: a consequence of altered nutrient delivery

    McLaughlin, T., Peck, M., Holst, Jens Juul & Deacon, Carolyn F., Apr 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 4, p. 1851-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Role of GLP-1 analogues and DDP-IV inhibitors in the treatment of type 2 diabetes

    Holst, Jens Juul & Deacon, Carolyn F., 2006, In : Avances en Diabetologia. 22, 2, p. 115-125 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Sacubitril/Valsartan Augments Postprandial Plasma Concentrations of Active GLP-1 When Combined With Sitagliptin in Men

    Albrechtsen, Nicolai Jacob Wewer, Mark, P. D., Terzic, D., Hansen, L. H., Andersen, U. Ø., Hartmann, Bolette, Carr, R. D., Gustafsson, Finn, Deacon, Carolyn F., Holst, Jens Juul, Goetze, Jens P. & Plomgaard, Peter Stendahl, 2019, In : Journal of Clinical Endocrinology and Metabolism. 104, 9, p. 3868-3876

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes

    Deacon, Carolyn F. & Holst, Jens Juul, 2009, In : Advances in Therapy. 26, 5, p. 488-99 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Secretion and dipeptidyl peptidase-4-mediated metabolism of incretin hormones after a mixed meal or glucose ingestion in obese compared to lean, nondiabetic men

    Carr, R. D., Larsen, M. O., Jelic, K., Lindgren, O., Vikman, J., Holst, Jens Juul, Deacon, Carolyn F. & Ahrén, B., 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 2, p. 872-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down?

    Nauck, M. A., Vardarli, I., Deacon, Carolyn F., Holst, Jens Juul & Meier, J., 2011, In : Diabetologia. 54, 1, p. 10-18 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Secretion of incretin hormones (GIP and GLP-1) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetes.

    Nauck, M. A., El-Ouaghlidi, A., Gabrys, B., Hücking, K., Holst, Jens Juul, Deacon, Carolyn F., Gallwitz, B., Schmidt, W. E. & Meier, J. J., 2004, In : Regulatory Peptides. 122, 3, p. 209-17 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Secretion of incretin hormones and the insulinotropic effect of gastric inhibitory polypeptide in women with a history of gestational diabetes

    Meier, J. J., Gallwitz, B., Askenas, M., Vollmer, K., Deacon, Carolyn F., Holst, Jens Juul, Schmidt, W. E. & Nauck, M. A., Sep 2005, In : Diabetologia. 48, 9, p. 1872-81 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects.

    Meier, J. J., Nauck, M. A., Kranz, D., Holst, Jens Juul, Deacon, Carolyn F., Gaeckler, D., Schmidt, W. E. & Gallwitz, B., 2004, In : Diabetes. 53, 3, p. 654-62 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Sensory nerve desensitization by resiniferatoxin improves glucose tolerance and increases insulin secretion in Zucker Diabetic Fatty rats and is associated with reduced plasma activity of dipeptidyl peptidase IV.

    Gram, D. X., Hansen, A. J., Deacon, Carolyn F., Brand, C. L., Ribel, U., Wilken, M., Carr, R. D., Svendsen, O. & Ahrén, B., 2005, In : European Journal of Pharmacology. 509, 2-3, p. 211-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Similar insulin secretory response to a gastric inhibitory polypeptide bolus injection at euglycemia in first-degree relatives of patients with type 2 diabetes and control subjects.

    Meier, J. J., Nauck, M. A., Siepmann, N., Greulich, M., Holst, Jens Juul, Deacon, Carolyn F., Schmidt, W. E. & Gallwitz, B., 2003, In : Metabolism - Clinical and Experimental. 52, 12, p. 1579-85 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Small intestinal glucose delivery affects the glucose-lowering effect of acute vildagliptin in type 2 diabetes

    Wu, T., Zhang, X., Trahair, L., Bound, M., Little, T., Deacon, Carolyn F., Horowitz, M., Jones, K. & Rayner, C., 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 12, p. 4769-4778

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Specificity and sensitivity of commercially available assays for glucagon and oxyntomodulin measurement in humans

    Bak, M. J., Albrechtsen, Nicolai Jacob Wewer, Pedersen, J., Hartmann, Bolette, Christensen, M., Vilsbøll, T., Knop, F. K., Deacon, Carolyn F., Dragsted, Lars Ove & Holst, Jens Juul, 2014, In : European Journal of Endocrinology. 170, 4, p. 529-538 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Specificity and sensitivity of commercially available assays for glucagon-like peptide-1 (GLP-1): Implications for GLP-1 measurements in clinical studies

    Bak, M. J., Albrechtsen, Nicolai Jacob Wewer, Pedersen, J., Knop, Filip Krag, Vilsbøll, Tina, Jørgensen, N. B., Hartmann, Bolette, Deacon, Carolyn F., Dragsted, Lars Ove & Holst, Jens Juul, 2014, In : Diabetes, Obesity and Metabolism. 16, 11, p. 1155-1164 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Stability of glucagon-like peptide-1 and glucagon in human plasma

    Albrechtsen, Nicolai Jacob Wewer, Bak, M. J., Hartmann, Bolette, Christensen, L. W., Kuhre, Rune Ehrenreich, Deacon, Carolyn F. & Holst, Jens Juul, 16 Jan 2015, In : Endocrine Connections. 4, 1, p. 50-57 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects.

    Meier, J. J., Gallwitz, B., Kask, B., Deacon, Carolyn F., Holst, Jens Juul, Schmidt, W. E. & Nauck, M. A., 2004, In : Diabetes. 53 Suppl 3, p. S220-4

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Suppression of glucagon secretion is lower after oral glucose administration than during intravenous glucose administration in human subjects

    Meier, J. J., Deacon, Carolyn F., Schmidt, W. E., Holst, Jens Juul & Nauck, M. A., 2007, In : Diabetologia. 50, 4, p. 806-813 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Targeting the intestinal L-cell for obesity and type 2 diabetes treatment

    Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Deacon, Carolyn F. & Holst, Jens Juul, 1 Jan 2014, In : Expert Review of Endocrinology & Metabolism. 9, 1, p. 61-72 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    The C-terminal extension of exendin-4 provides additional metabolic stability when added to GLP-1, while there is minimal effect of truncating exendin-4 in anaesthetized pigs

    Simonsen, L., Holst, Jens Juul, Madsen, K. & Deacon, Carolyn F., 10 Feb 2013, In : Regulatory Peptides. 181, 10, p. 17-21 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    The Effect of Exogenous GLP-1 on Food Intake is Lost in Male Truncally Vagotomized Subjects with Pyloroplasty

    Plamboeck, A., Veedfald, Simon, Deacon, Carolyn F., Hartmann, Bolette, Wettergren, A., Svendsen, Lars Bo, Meisner, S., Hovendahl, C., Vilsbøll, Tina, Knop, Filip Krag & Holst, Jens Juul, 18 Apr 2013, In : American Journal of Physiology: Gastrointestinal and Liver Physiology. 304, p. G1117-G1127 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    The Use of Gastrostomy Tube for the Long-Term Remission of Hyperinsulinemic Hypoglycemia After Roux-en-y Gastric Bypass: A Case Report

    Craig, C., Lamendola, C., Holst, Jens Juul, Deacon, Carolyn F. & McLaughlin, T., 2015, In : aace clinical case reports. 1, 2, p. e84-e87 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides: a randomized trial

    Samkani, A., Skytte, M. G. J., Anholm, C., Astrup, Arne, Deacon, Carolyn F., Holst, Jens Juul, Madsbad, S., Boston, R., Krarup, T. & Haugaard, Steen Bendix, 2018, In : Lipids in Health and Disease. 17, 9 p., 295.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients.

    Balas, B., Baig, M. R., Watson, C., Dunning, B. E., Ligueros-Saylan, M., Wang, Y., He, Y., Darland, C., Holst, Jens Juul, Deacon, Carolyn F., Cusi, K., Mari, A., Foley, J. E. & DeFronzo, R. A., 2007, In : Journal of Clinical Endocrinology and Metabolism. 92, 4, p. 1249-55 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose

    Utzschneider, K. M., Tong, J., Montgomery, B., Udayasankar, J., Gerchman, F., Marcovina, S. M., Watson, C. E., Ligueros-Saylan, M. A., Foley, J. E., Holst, Jens Juul, Deacon, Carolyn F. & Kahn, S. E., 2007, In : Diabetes Care. 31, 1, p. 108-113 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    The effect of DPP-4 inhibition with sitagliptin on incretin secretion and on fasting and postprandial glucose turnover in subjects with impaired fasting glucose

    Bock, G., Man, C. D., Micheletto, F., Basu, R., Rn, P. D. G., Laugen, J., Deacon, Carolyn F., Holst, Jens Juul, Toffolo, G., Cobelli, C., Rizza, R. A. & Vella, A., 2010, In : Clinical Endocrinology. 73, p. 189-196

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    The effect of dipeptidyl peptidase 4 inhibition on gastric volume, satiation and enteroendocrine secretion in Type 2 diabetes: a double blind, placebo-controlled crossover study.

    Vella, A., Bock, G., Giesler, P. D., Burton, D. B., Serra, D. B., Saylan, M. L., Deacon, Carolyn F., Foley, J. E., Rizza, R. A. & Camilleri, M., 2008, In : Clinical Endocrinology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    The effects of sitagliptin on gastric emptying in healthy humans – a randomised controlled study

    Stevens, J., Horowitz, M., Deacon, Carolyn F., Nauck, M., Rayner, C. & Jones, K., 2012, In : Alimentary Pharmacology and Therapeutics. 36, 4, p. 379-390

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    The elimination rates of intact GIP as well as its primary metabolite, GIP 3-42, are similar in type 2 diabetic patients and healthy subjects.

    Vilsbøll, Tina, Agersø, H., Lauritsen, T., Deacon, Carolyn F., Aaboe, K., Madsbad, Sten, Krarup, T. & Holst, Jens Juul, 2006, In : Regulatory Peptides. 137, 3, p. 168-72 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    The glucagon-like peptide-1 metabolite GLP-1-(9-36) amide reduces postprandial glycemia independently of gastric emptying and insulin secretion in humans.

    Meier, J. J., Gethmann, A., Nauck, M. A., Götze, O., Schmitz, F., Deacon, Carolyn F., Gallwitz, B., Schmidt, W. E. & Holst, Jens Juul, 2006, In : American Journal of Physiology: Endocrinology and Metabolism. 290, 6, p. E1118-23

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action

    Hare, K. J., Vilsbøll, Tina, Asmar, M., Deacon, Carolyn F., Knop, Filip Krag & Holst, Jens Juul, 1 Jul 2010, In : Diabetes. 59, 7, p. 1765-70 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    The impact of dipeptidyl peptidase 4 inhibition on incretin effect, glucose tolerance, and gastrointestinal-mediated glucose disposal in healthy subjects

    Rhee, N. A., Østoft, S. H., Holst, Jens Juul, Deacon, Carolyn F., Vilsbøll, T. & Knop, Filip Krag, 16 Jun 2014, In : European Journal of Endocrinology. 171, 3, p. 353-362 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    The incretin enhancer vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed -cell function in patients with type 2 diabetes

    Mari, A., Sallas, W. M., He, Y. L., Watson, C., Ligueros-Saylan, M., Dunning, B. E., Deacon, Carolyn F., Holst, Jens Juul & Foley, J. E., 2005, In : Journal of Clinical Endocrinology and Metabolism. 90, p. 4888-4894

    Research output: Contribution to journalJournal articleResearch

ID: 9220