Carolyn F. Deacon

Carolyn F. Deacon

Associate Professor


  1. Published

    Dipeptidyl peptidase-4 inhibition increases portal concentrations of intact glucagon-like peptide-1 (GLP-1) to a greater extent than peripheral concentrations in anaesthetised pigs

    Hjøllund, K. R., Deacon, Carolyn F. & Holst, Jens Juul, 2011, In: Diabetologia. 54, 8, p. 2206-8 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

  2. Published

    On the treatment of diabetes mellitus with glucagon-like peptide-1.

    Holst, Jens Juul, Deacon, Carolyn F., Toft-Nielsen, M. & Bjerre-Knudsen, L., 1998, In: Annals of the New York Academy of Sciences. 865, p. 336-343

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes

    Holst, Jens Juul & Deacon, Carolyn F., 1998, In: Diabetes. 47, p. 1663-1670

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Role of GLP-1 analogues and DDP-IV inhibitors in the treatment of type 2 diabetes

    Holst, Jens Juul & Deacon, Carolyn F., 2006, In: Avances en Diabetologia. 22, 2, p. 115-125 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    New horizons in diabetes therapy

    Holst, Jens Juul & Deacon, Carolyn F., 2007, In: Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 7, 1, p. 49-55 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Physiology of the Incretin Hormones, GIP and GLP-1-Regulation of Release and Posttranslational Modifications

    Holst, Jens Juul, Albrechtsen, Nicolai Jacob Wewer, Rosenkilde, Mette & Deacon, Carolyn F., 2019, In: Comprehensive Physiology. 9, 4, p. 1339-1381

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Glucagon-like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus.

    Holst, Jens Juul & Deacon, Carolyn F., 2004, In: Current Opinion in Pharmacology. 4, 6, p. 589-96 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Glucagon-like peptide-1, glucose homeostasis and diabetes.

    Holst, Jens Juul, Deacon, Carolyn F., Vilsbøll, Tina, Krarup, T. & Madsbad, Sten, 2008, In: Trends in Molecular Medicine. 14, 4, p. 161-8 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Glucagon-like peptide-1 mediates the therapeutic actions of Dpp-IV inhibitors

    Holst, Jens Juul & Deacon, Carolyn F., 2005, In: Diabetologia. 48, p. 612-615

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    The incretin system and its role in type 2 diabetes mellitus

    Holst, Jens Juul, Vilsbøll, Tina & Deacon, Carolyn F., 2008, In: Molecular and Cellular Endocrinology. 297, 1-2, p. 127-136 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    For debate: Are antidiabetic actions of DPP-IV inhibitors mediated by glucagon-like peptide- 1?

    Holst, Jens Juul & Deacon, Carolyn F., 2005, In: Diabetologia. 48, p. 612-615

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors

    Holst, Jens Juul & Deacon, Carolyn F., Apr 2005, In: Diabetologia. 48, 4, p. 612-5 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Posttranslational processing of proglucagon and postsecretory fate of proglucagon products.

    Holst, Jens Juul, Ørskov, C., Hartmann, B. & Deacon, Carolyn F., 1997, The Insulinotropic Gut Hormone Glucagon-like Peptide-1.. Basel: Karger, p. 24-48

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  14. Published

    Is there a place for incretin therapies in obesity and prediabetes?

    Holst, Jens Juul & Deacon, Carolyn F., 13 Feb 2013, In: Trends in Endocrinology and Metabolism. 24, 3, p. 145-152 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Glucagon-like peptides 1 and 2, enteroglucagon, glicentin and oxyntomodulin

    Holst, Jens Juul, Deacon, Carolyn F., Hartmann, Bolette & Pedersen, J., 2013, Handbook of Biologically Active Peptides . Kastin, AJ. (ed.). 2 ed. Elsevier, p. 1241-1250 10 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

  16. Published

    Activation of GLP-1 receptors on vascular smooth muscle cells reduces the autoregulatory response in afferent arterioles and increases renal blood flow

    Jensen, E. P., Poulsen, Steen Seier, Kissow, Hannelouise, Holstein-Rathlou, N., Deacon, Carolyn F., Jensen, B. L., Holst, Jens Juul & Sorensen, Charlotte Mehlin, 15 Apr 2015, In: A J P: Renal Physiology (Online). 308, 8, p. F867-F877 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut- and GLP-1R-dependent manner

    Jepsen, S. L., Albrechtsen, Nicolai Jacob Wewer, Windeløv, J. A., Galsgaard, Katrine Douglas, Hunt, J. E., Farb, T. B., Kissow, Hannelouise, Pedersen, J., Deacon, Carolyn F., Martin, R. E. & Holst, Jens Juul, 2021, In: JCI insight. 6, 4, 15 p., e143228.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Paracrine Crosstalk between Intestinal L- and D-cells Controls Secretion of Glucagon-Like Peptide-1 in mice

    Jepsen, S. L., Grunddal, K. V., Albrechtsen, Nicolai Jacob Wewer, Engelstoft, M. S., Gabe, M. B. N., Jensen, E. P., Ørskov, Cathrine, Poulsen, Steen Seier, Rosenkilde, M. M., Pedersen, J., Gribble, F. M., Reimann, F., Deacon, Carolyn F., Schwartz, Thue W., Christ, A. D., Martin, R. E. & Holst, Jens Juul, 2019, In: American Journal of Physiology: Endocrinology and Metabolism. 317, 6, p. E1081-E1093

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    GLP-1 signals via ERK in peripheral nerve and prevents nerve dysfunction in diabetic mice

    Jolivalt, C., Fineman, M., Deacon, Carolyn F., Carr, R. & Calcutt, N., Nov 2011, In: Diabetes, Obesity and Metabolism. 13, 11, p. 990-1000 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Neprilysin Inhibition Increases Glucagon Levels in Humans and Mice With Potential Effects on Amino Acid Metabolism

    Kjeldsen, Sasha Alexandra Sampson, Hansen, Lasse Holst, Esser, N., Mongovin, S., Winther-Sørensen, Marie, Galsgaard, Katrine Douglas, Hunt, J. E., Kissow, Hannelouise, Ceutz, F. R., Terzic, D., Mark, P. D., Plomgaard, Peter Stendahl, Goetze, Jens P. , Goossens, G. H., Blaak, E. E., Deacon, Carolyn F., Rosenkilde, Mette, Zraika, S., Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2021, In: Endocrine Research. 5, 9, 15 p., bvab084.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published
  22. Published

    What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell?

    Kuhre, Rune Ehrenreich, Deacon, Carolyn F., Holst, Jens Juul & Petersen, N., 2021, In: Frontiers in Endocrinology. 12, 19 p., 694284.

    Research output: Contribution to journalReviewResearchpeer-review

  23. Published

    Measurement of the incretin hormones: glucagon-like peptide-1 and glucose-dependent insulinotropic peptide

    Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Hartmann, Bolette, Deacon, Carolyn F. & Holst, Jens Juul, Apr 2015, In: Journal of Diabetes and its Complications. 29, 3, p. 445-450 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.

    Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Larsen, Olav, Jepsen, S. L., Balk-Møller, E., Andersen, Daniel Bjørklund, Deacon, Carolyn F., Schoonjans, K., Reimann, F., Gribble, F. M., Albrechtsen, Reidar, Hartmann, Bolette, Rosenkilde, Mette & Holst, Jens Juul, 2018, In: Molecular Metabolism. 11, p. 84-95 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Peptide production and secretion in GLUTag, NCI-H716 and STC-1 cells: a comparison to native L-cells.

    Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Deacon, Carolyn F., Balk-Møller, E., Rehfeld, Jens Frederik, Relman, F., Gribble, F. M. & Holst, Jens Juul, 2016, In: Journal of Molecular Endocrinology. 56, p. 201-211

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Pancreatic α-cell hyperplasia and hyperglucagonemia due to a mutation of the glucagon

    Larger, E., Albrechtsen, Nicolai Jacob Wewer, Hansen, L. H., Gelling, R. W., Capeau, J., Deacon, Carolyn F., Madsen, O. D., Yakushiji, F., Meyts, P. D., Holst, Jens Juul & Nishimura, E., 2016, In: Endocrinology, Diabetes & Metabolism Case Reports. 2016, 6 p., EDM160081.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Valine pyrrolidide preserves intact glucose-dependent insulinotropic peptide and improves abnormal glucose tolerance in minipigs with reduced beta-cell mass.

    Larsen, M. O., Rolin, B., Ribel, U., Wilken, M., Deacon, Carolyn F., Svendsen, O., Gotfredsen, C. F. & Carr, R. D., 2003, In: Experimental Diabesity Research. 4, 2, p. 93-105 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Dissociated incretin hormone response to protein versus fat ingestion in obese subjects

    Lindgren, O., Carr, R., Holst, Jens Juul, Deacon, Carolyn F. & Ahren, B., Jul 2011, In: Diabetes, Obesity and Metabolism Online. 13, 9, p. 863-865 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Incretin hormone and insulin responses to oral versus intravenous lipid administration in humans

    Lindgren, O., Carr, R. D., Deacon, Carolyn F., Holst, Jens Juul, Pacini, G., Mari, A. & Ahrén, B., Aug 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 8, p. 2519-2524 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Incretin effect after oral amino Acid ingestion in humans

    Lindgren, O., Pacini, G., Tura, A., Holst, Jens Juul, Deacon, Carolyn F. & Ahrén, B., Mar 2015, In: The Journal of clinical endocrinology and metabolism. 100, 3, p. 1172-6 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Differential islet and incretin hormone responses in morning versus afternoon after standardized meal in healthy men

    Lindgren, O., Mari, A., Deacon, Carolyn F., Carr, R. D., Winzell, M. S., Vikman, J. & Ahrén, B., 2009, In: Journal of Clinical Endocrinology and Metabolism. 94, 8, p. 2887-92 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    An overview of once-weekly glucagon-like peptide-1 receptor agonists--available efficacy and safety data and perspectives for the future

    Madsbad, Sten, Kielgast, U., Asmar, M., Deacon, Carolyn F., Torekov, Signe Sørensen & Holst, Jens Juul, May 2011, In: Diabetes, Obesity and Metabolism. 13, 5, p. 394-407 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Glucagon-like peptide receptor agonists and dipeptidyl peptidase-4 inhibitors in the treatment of diabetes: a review of clinical trials

    Madsbad, Sten, Krarup, T., Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten, Krarup, T., Deacon, C. F. & Holst, J. J., 2008, In: Current Opinion in Clinical Nutrition and Metabolic Care. 11, 4, p. 491-9 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Glucagon-like peptide receptor agonists and dipeptidyl peptidase-4 inhibitors in the treatment of diabetes: a review of clinical trials

    Madsbad, Sten, Krarup, T., Deacon, Carolyn F. & Holst, Jens Juul, Jul 2008, In: Current Opinion in Clinical Nutrition and Metabolic Care. 11, 4, p. 491-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed beta-cell function in patients with type 2 diabetes

    Mari, A., Sallas, W. M., He, Y. L., Watson, C., Ligueros-Saylan, M., Dunning, B. E., Deacon, Carolyn F., Holst, Jens Juul & Foley, J. E., Aug 2005, In: The Journal of clinical endocrinology and metabolism. 90, 8, p. 4888-94 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Vildagliptin, a dipeptidyl peptidase-IV inhibitor improves model-assessed beta-cell function in patients with type 2 diabetes

    Mari, A., Sallas, W. M., He, Y. L., Watson, C., Ligueros-Saylan, M., Duning, B. E., Deacon, Carolyn F., Holst, Jens Juul & Foley, J. E., 2005, In: J. Clin. Endocrinol. Metab.. 90, p. 4888-4894

    Research output: Contribution to journalJournal articleResearch

  37. Published

    The incretin enhancer vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed -cell function in patients with type 2 diabetes

    Mari, A., Sallas, W. M., He, Y. L., Watson, C., Ligueros-Saylan, M., Dunning, B. E., Deacon, Carolyn F., Holst, Jens Juul & Foley, J. E., 2005, In: Journal of Clinical Endocrinology and Metabolism. 90, p. 4888-4894

    Research output: Contribution to journalJournal articleResearch

  38. Published

    Incretin-based therapies– review of the physiology, pharmacology and emerging clinical experience

    Martin, J., Deacon, Carolyn F., Gorrell, M. & Prins, J., 2011, In: Internal Medicine Journal (Online). 41, p. 299-307 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  39. Published

    Fructose intervention for 12 weeks does not impair glycemic control or incretin hormone responses during oral glucose or mixed meal tests in obese men

    Matikainen, N., Söderlund, S., Björnson, E., Bogl, L. H., Pietiläinen, K. H., Hakkarainen, A., Lundbom, N., Eliasson, B., Räsänen, S. M., Rivellese, A., Patti, L., Prinster, A., Riccardi, G., Després, J., Alméras, N., Holst, Jens Juul, Deacon, Carolyn F., Borén, J. & Taskinen, M., Jun 2017, In: Nutrition, Metabolism & Cardiovascular Diseases. 27, 6, p. 534-542 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men

    Matikainen, N., Björnson, E., Söderlund, S., Borén, C., Eliasson, B., Pietiläinen, K. H., Bogl, L. H., Hakkarainen, A., Lundbom, N., Rivellese, A., Riccardi, G., Després, J., Alméras, N., Holst, Jens Juul, Deacon, Carolyn F., Borén, J. & Taskinen, M., 2016, In: PLOS ONE. 11, 1, p. 1-15 15 p., e0145890.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Reversible hyperinsulinemic hypoglycemia after gastric bypass: a consequence of altered nutrient delivery

    McLaughlin, T., Peck, M., Holst, Jens Juul & Deacon, Carolyn F., Apr 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 4, p. 1851-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia

    Meier, J. J., Gallwitz, B., Siepmann, N., Holst, Jens Juul, Deacon, Carolyn F., Schmidt, W. E. & Nauck, M. A., Jun 2003, In: Diabetologia. 46, 6, p. 798-801 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Secretion of incretin hormones and the insulinotropic effect of gastric inhibitory polypeptide in women with a history of gestational diabetes

    Meier, J. J., Gallwitz, B., Askenas, M., Vollmer, K., Deacon, Carolyn F., Holst, Jens Juul, Schmidt, W. E. & Nauck, M. A., Sep 2005, In: Diabetologia. 48, 9, p. 1872-81 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Insulinotropic effect of gastric inhibitory polypeptide (GIP) in women with a history of gestational diabetes

    Meier, J. J., Gallwitz, B., Askenas, M., Vollmer, K., Deacon, Carolyn F., Holst, Jens Juul, Schmidt, W. E. & Nauck, M. A., 2005, In: Diabetologia. 48, p. 1872-1881

    Research output: Contribution to journalJournal articleResearch

  45. Published

    Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia

    Meier, J. J., Gallwitz, N., Siepmann, N., Holst, Jens Juul, Deacon, Carolyn F., Schmidt, W. E. & Nauck, M. A., 2003, In: Diabetologia. 46, p. 798-801

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Suppression of glucagon secretion is lower after oral glucose administration than during intravenous glucose administration in human subjects

    Meier, J. J., Deacon, Carolyn F., Schmidt, W. E., Holst, Jens Juul & Nauck, M. A., 2007, In: Diabetologia. 50, 4, p. 806-813 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes

    Meier, J. J., Huking, K., Holst, Jens Juul, Deacon, Carolyn F., Schmiegel, W. H. & Nauck, M. A., 2001, In: Diabetes. 50, p. 2497-2504

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Influence of gastric inhibitory polypeptide on pentagastrin-stimulated gastric acid secretion in patients with type 2 diabetes and healthy controls.

    Meier, J. J., Nauck, M. A., Kask, B., Holst, Jens Juul, Deacon, Carolyn F., Schmidt, W. E. & Gallwitz, B., 2006, In: World Journal of Gastroenterology. 12, 12, p. 1874-80 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Impact of exogenous hyperglucagonemia on postprandial concentrations of gastric inhibitory polypeptide and glucagon-like peptide-1 in humans

    Meier, J. J., Ritter, P. R., Jacob, A., Menge, B. A., Deacon, Carolyn F., Schmidt, W. E., Nauck, M. A. & Holst, Jens Juul, 1 Aug 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 8, p. 4061-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    The glucagon-like peptide-1 metabolite GLP-1-(9-36) amide reduces postprandial glycemia independently of gastric emptying and insulin secretion in humans.

    Meier, J. J., Gethmann, A., Nauck, M. A., Götze, O., Schmitz, F., Deacon, Carolyn F., Gallwitz, B., Schmidt, W. E. & Holst, Jens Juul, 2006, In: American Journal of Physiology: Endocrinology and Metabolism. 290, 6, p. E1118-23

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Similar insulin secretory response to a gastric inhibitory polypeptide bolus injection at euglycemia in first-degree relatives of patients with type 2 diabetes and control subjects.

    Meier, J. J., Nauck, M. A., Siepmann, N., Greulich, M., Holst, Jens Juul, Deacon, Carolyn F., Schmidt, W. E. & Gallwitz, B., 2003, In: Metabolism - Clinical and Experimental. 52, 12, p. 1579-85 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects.

    Meier, J. J., Gallwitz, B., Kask, B., Deacon, Carolyn F., Holst, Jens Juul, Schmidt, W. E. & Nauck, M. A., 2004, In: Diabetes. 53 Suppl 3, p. S220-4

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    The reduction in hepatic insulin clearance after oral glucose is not mediated by gastric inhibitory polypeptide (GIP).

    Meier, J. J., Gallwitz, B., Siepmann, N., Holst, Jens Juul, Deacon, Carolyn F., Schmidt, W. E. & Nauck, M. A., 2003, In: Regulatory Peptides. 113, 1-3, p. 95-100 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects.

    Meier, J. J., Nauck, M. A., Kranz, D., Holst, Jens Juul, Deacon, Carolyn F., Gaeckler, D., Schmidt, W. E. & Gallwitz, B., 2004, In: Diabetes. 53, 3, p. 654-62 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Loss of inverse relationship between pulsatile insulin and glucagon secretion in patients with type 2 diabetes

    Menge, B. A., Grüber, L., Jørgensen, S. M., Deacon, Carolyn F., Schmidt, W. E., Veldhuis, J. D., Holst, Jens Juul & Meier, J. J., Aug 2011, In: Diabetes. 60, 8, p. 2160-2168 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    GIP does not potentiate the antidiabetic effects of GLP-1 in hyperglycemic patients with type 2 diabetes

    Mentis, N., Vardarli, I., Köthe, L. D., Holst, Jens Juul, Deacon, Carolyn F., Theodorakis, M., Meier, J. J. & Nauck, M. A., 2011, In: Diabetes. 60, 4, p. 1270-1276 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Dipeptidyl peptidase-4 inhibitors administered in combination with metformin result in an additive increase in the plasma concentration of active GLP-1

    Migoya, E. M., Bergeron, R., Miller, J. L., Snyder, R. N. K., Tanen, M., Hilliard, D., Weiss, B., Larson, P., Gutierrez, M., Jiang, G., Liu, F., Pryor, K. A., Yao, J., Zhu, L., Holst, Jens Juul, Deacon, Carolyn F., Herman, G., Thornberry, N., Amatruda, J., Williams-Herman, D., Wagner, J. A. & SinhaRoy, R., 1 Dec 2010, In: Clinical Pharmacology and Therapeutics. 88, 6, p. 801-8 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down?

    Nauck, M. A., Vardarli, I., Deacon, Carolyn F., Holst, Jens Juul & Meier, J., 2011, In: Diabetologia. 54, 1, p. 10-18 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    No evidence of tachyphylaxis for insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) in subjects with type 2 diabetes, their first-degree relatives, or in healthy subjects

    Nauck, M. A., Holle, H., Kahle, M., Tytko, A., Deacon, Carolyn F., Holst, Jens Juul & Meier, J. J., 2020, In: Peptides. 125, 170176.

    Research output: Contribution to journalReviewResearchpeer-review

  60. Published

    Secretion of incretin hormones (GIP and GLP-1) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetes.

    Nauck, M. A., El-Ouaghlidi, A., Gabrys, B., Hücking, K., Holst, Jens Juul, Deacon, Carolyn F., Gallwitz, B., Schmidt, W. E. & Meier, J. J., 2004, In: Regulatory Peptides. 122, 3, p. 209-17 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Quantification of the contribution of GLP-1 to mediating insulinotropic effects of DPP-4 inhibition with vildagliptin in healthy subjects and type 2-diabetic patients using exendin [9-39] as a GLP-1 receptor antagonist.

    Nauck, M. A., Kind, J., Köthe, L. D., Holst, Jens Juul, Deacon, Carolyn F., Broschag, M., He, Y., Kjems, L. & Foley, J., 2016, In: Diabetes. 65, 8, p. 2440-2447 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    Addition of a dipeptidyl peptidase-4 inhibitor, sitagliptin, to ongoing therapy with the glucagon-like peptide-1 receptor agonist liraglutide: A randomized controlled trial in patients with type 2 diabetes

    Nauck, M. A., Kahle, M., Baranov, O., Deacon, Carolyn F. & Holst, Jens Juul, 6 Feb 2017, In: Diabetes, Obesity and Metabolism. 19, 2, p. 200-207 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on incretin hormones

    Olthof, M., van Dijk, A., Deacon, Carolyn F., Heine, R. & van Dam, R., 2011, In: Nutrition & Metabolism. 8, p. Artikel 10 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both mediators of the degradation of glucagon-like peptide 1 in the anaesthetised pig

    Plamboeck, A., Holst, Jens Juul, Carr, R. D. & Deacon, Carolyn F., Sep 2005, In: Diabetologia. 48, 9, p. 1882-90 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    Neutral Endopeptidase 24.11 and dipeptidyl peptidase IV are both physiological mediators of the degradation of glucagon-like peptide-1 in the anaesthetized pig

    Plamboeck, A., Holst, Jens Juul, Carr, R. D. & Deacon, Carolyn F., 2005, In: Diabetologia. 48, p. 1882-1890

    Research output: Contribution to journalJournal articleResearchpeer-review

  66. Published

    Characterization of oral and intravenous glucose handling in truncally vagotomised subjects with pyloroplasty

    Plamboeck, A., Veedfald, Simon, Deacon, Carolyn F., Hartmann, Bolette, Wettergren, A., Svendsen, L. B., Meisner, S., Hovendal, C., Knop, F. K., Vilsbøll, Tina & Holst, Jens Juul, 23 May 2013, In: European Journal of Endocrinology. 169, p. 187-201 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. Published

    Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both involved in regulating the metabolic stability of glucagon-like peptide-1 in vivo.

    Plamboeck, A., Holst, Jens Juul, Carr, R. D. & Deacon, Carolyn F., 2003, In: Advances in Experimental Medicine and Biology. 524, p. 303-12 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  68. Published

    The role of efferent cholinergic transmission for the insulinotropic and glucagonostatic effects of GLP-1

    Plamboeck, A., Veedfald, Simon, Deacon, Carolyn F., Hartmann, Bolette, Vilsbøll, T., Knop, F. K. & Holst, Jens Juul, Sep 2015, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 309, 5, p. R544-51 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  69. Published

    The Effect of Exogenous GLP-1 on Food Intake is Lost in Male Truncally Vagotomized Subjects with Pyloroplasty

    Plamboeck, A., Veedfald, Simon, Deacon, Carolyn F., Hartmann, Bolette, Wettergren, A., Svendsen, L. B., Meisner, S., Hovendahl, C., Vilsbøll, Tina, Knop, F. K. & Holst, Jens Juul, 18 Apr 2013, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 304, p. G1117-G1127 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  70. Published

    Linagliptin, a selective DPP-4 inhibitor, inhibits DPP-4, increases incretin levels, lowers glucagon, and improves glycaemic control in patients with Type 2 diabetes.

    Rauch, T., Graefe-Mody, U., Deacon, Carolyn F., Ring, A., Holst, Jens Juul, Woerle, H., Dugi, K. & Heise, T., 2012, In: Diabetes Therapy. 3, 1, p. 10

    Research output: Contribution to journalJournal articleResearchpeer-review

  71. Published

    Linagliptin increases incretin levels, lowers glucagon, and improves glycemic control in type 2 diabetes mellitus

    Rauch, T., Graefe-Mody, U., Deacon, Carolyn F., Ring, A., Holst, Jens Juul, Woerle, H., Dugi, K. A. & Heise, T., Nov 2012, In: Diabetes Therapy. 3, 1, p. 10

    Research output: Contribution to journalJournal articleResearchpeer-review

  72. Published

    The impact of dipeptidyl peptidase 4 inhibition on incretin effect, glucose tolerance, and gastrointestinal-mediated glucose disposal in healthy subjects

    Rhee, N. A., Østoft, S. H., Holst, Jens Juul, Deacon, Carolyn F., Vilsbøll, T. & Knop, F. K., 16 Jun 2014, In: European Journal of Endocrinology. 171, 3, p. 353-362 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. Published

    NN2211: a long-acting glucagon-like peptide-1 derivative with anti-diabetic effects in glucose-intolerant pigs.

    Ribel, U., Larsen, M. O., Rolin, B., Carr, R. D., Wilken, M., Sturis, J., Westergaard, L., Deacon, Carolyn F. & Knudsen, L. B., 2002, In: European Journal of Pharmacology. 451, 2, p. 217-25 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  74. Published

    Impaired crosstalk between pulsatile insulin and glucagon secretion in prediabetic individuals

    Rohrer, S., Menge, B. A., Grüber, L., Deacon, Carolyn F., Schmidt, W. E., Veldhuis, J. D., Holst, Jens Juul & Meier, J. J., 2012, In: Journal of Clinical Endocrinology and Metabolism. 97, 5, p. E791-E795

    Research output: Contribution to journalJournal articleResearchpeer-review

  75. Published

    The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice.

    Rolin, B., Larsen, M. O., Gotfredsen, C. F., Deacon, Carolyn F., Carr, R. D., Wilken, M. & Knudsen, L. B., 2002, In: American Journal of Physiology: Endocrinology and Metabolism. 283, 4, p. E745-52

    Research output: Contribution to journalJournal articleResearchpeer-review

  76. Published

    The major glucagon-like peptide-1 metabolite, GLP-1-(9-36)-amide, does not affect glucose or insulin levels in mice.

    Rolin, B., Deacon, Carolyn F., Carr, R. D. & Ahrén, B., 2004, In: European Journal of Pharmacology. 494, 2-3, p. 283-8 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  77. Published

    Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia in subjects with impaired glucose tolerance.

    Rosenstock, J., Foley, J. E., Rendell, M., Landin-Olsson, M., Holst, Jens Juul, Deacon, Carolyn F., Rochotte, E. & Baron, M. A., 2008, In: Diabetes Care. 31, 1, p. 30-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    Plasma dipeptidyl peptidase-IV activity in patients with type-2 diabetes mellitus correlates positively with HbAlc levels, but is not acutely affected by food intake

    Ryskjaer, J., Deacon, Carolyn F., Carr, R. D., Krarup, T., Madsbad, Sten, Holst, Jens Juul, Vilsbøll, Tina, Ryskjaer, J., Deacon, C. F., Carr, R. D., Krarup, T., Madsbad, Sten, Holst, J. J. & Vilsbøll, T., 1 Sep 2006, In: European Journal of Endocrinology. 155, 3, p. 485-93 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  79. Published

    The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides: a randomized trial

    Samkani, A., Skytte, M. G. J., Anholm, C., Astrup, Arne, Deacon, Carolyn F., Holst, Jens Juul, Madsbad, S., Boston, R., Krarup, T. & Haugaard, Steen Bendix, 2018, In: Lipids in Health and Disease. 17, 9 p., 295.

    Research output: Contribution to journalJournal articleResearchpeer-review

  80. Published

    A carbohydrate-reduced high-protein diet acutely decreases postprandial and diurnal glucose excursions in type 2 diabetes patients

    Samkani, A., Skytte, M. G. J., Kandel, D., Kjaer, S., Astrup, Arne, Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten, Rehfeld, Jens Frederik, Haugaard, Steen Bendix & Krarup, T., 2018, In: British Journal of Nutrition. 119, 8, p. 910-917 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  81. Published

    Acute Effects of Dietary Carbohydrate Restriction on Glycemia, Lipemia and Appetite Regulating Hormones in Normal-Weight to Obese Subjects

    Samkani, A. A., Skytte, M. J., Thomsen, M. N., Astrup, Arne, Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten, Rehfeld, Jens Frederik, Krarup, T. & Haugaard, Steen Bendix, Sep 2018, In: Nutrients. 10, 9, p. 1-14 14 p., 1285.

    Research output: Contribution to journalJournal articleResearchpeer-review

  82. Published

    Normal secretion and action of the gut incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in young men with low birth weight

    Schou, J. H., Pilgaard, K., Vilsbøll, Tina, Jensen, C. B., Deacon, Carolyn F., Holst, Jens Juul, Vølund, A., Madsbad, Sten & Vaag, Allan, 2005, In: Journal of Clinical Endocrinology and Metabolism. 90, 8, p. 4912-19 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  83. Published

    Inhibition of neutral endopeptidase 24.11 does not potentiate the improvement in glycemic control obtained with dipeptidyl peptidase-4 inhibition in diabetic Goto-Kakizaki rats

    Simonsen, L., Pilgaard, S., Carr, R. D., Kanstrup, A. B., Holst, Jens Juul & Deacon, Carolyn F., 2009, In: Hormone and Metabolic Research. 41, 11, p. 851-3 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  84. Published

    The C-terminal extension of exendin-4 provides additional metabolic stability when added to GLP-1, while there is minimal effect of truncating exendin-4 in anaesthetized pigs

    Simonsen, L., Holst, Jens Juul, Madsen, K. & Deacon, Carolyn F., 10 Feb 2013, In: Regulatory Peptides. 181, 10, p. 17-21 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  85. Published

    Exendin-4, but not glucagon-like peptide-1, is cleared exclusively by glomerular filtration in anaesthetised pigs

    Simonsen, L., Holst, Jens Juul & Deacon, Carolyn F., Apr 2006, In: Diabetologia. 49, 4, p. 706-12 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  86. Published

    Long-term exendin-4 treatment delays natural deterioration of glycaemic control in diabetic Goto-Kakizaki rats

    Simonsen, L., Pilgaard, S., Orskov, C., Hartmann, Bolette, Holst, Jens Juul & Deacon, Carolyn F., 2009, In: Diabetes, Obesity and Metabolism. 11, 9, p. 884-90 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  87. Published

    Exendin-4, but not glucagon-like peptide-1, is cleared exclusively by glomerular filtration in anaesthetised pigs

    Simonsen, L., Holst, Jens Juul & Deacon, Carolyn F., 2006, In: Diabetologia. 49, 4, p. 706-712 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  88. Published

    Exendin-4, but not dipeptidyl peptidase IV inhibition, increases small intestinal mass in GK rats.

    Simonsen, L., Pilgaard, S., Orskov, C., Rosenkilde, Mette, Hartmann, B., Holst, Jens Juul & Deacon, Carolyn F., 2007, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 293, 1, p. G288-95

    Research output: Contribution to journalJournal articleResearchpeer-review

  89. Published

    Overnight hypoxic exposure and glucagon-like peptide-1 and leptin levels in humans.

    Snyder, E. M., Carr, R. D., Deacon, Carolyn F. & Johnson, B. D., 2008, In: Applied Physiology, Nutrition and Metabolism. 33, 5, p. 929-35 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  90. Published

    Effects of short-term therapy with glibenclamide and repaglinide on incretin hormones and oxidative damage associated with postprandial hyperglycaemia in people with type 2 diabetes mellitus

    Stephens, J. W., Bodvarsdottir, T. B., Wareham, K., Prior, S. L., Bracken, R. M., Lowe, G. D., Rumley, A., Dunseath, G., Luzio, S., Deacon, Carolyn F., Holst, Jens Juul & Bain, S. C., Nov 2011, In: Diabetes Research and Clinical Practice. 94, 2, p. 199-206 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  91. Published

    The effects of sitagliptin on gastric emptying in healthy humans – a randomised controlled study

    Stevens, J., Horowitz, M., Deacon, Carolyn F., Nauck, M., Rayner, C. & Jones, K., 2012, In: Alimentary Pharmacology and Therapeutics. 36, 4, p. 379-390

    Research output: Contribution to journalJournal articleResearchpeer-review

  92. Published

    GLP-1 derivative liraglutide in rats with beta-cell deficiencies: influence of metabolic state on beta-cell mass dynamics.

    Sturis, J., Gotfredsen, C. F., Rømer, J., Rolin, B., Ribel, U., Brand, C. L., Wilken, M., Wassermann, K., Deacon, Carolyn F., Carr, R. D. & Knudsen, L. B., 2003, In: British Journal of Pharmacology. 140, 1, p. 123-32 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  93. Published

    Effects of a six-week intervention with glucagon-like peptide-1 receptor analogue on pancreatic volume, oedema and DNA synthesis in obese men

    Svane, M. S., Johannesen, H. H., Martinussen, C., Bojsen-Moller, K. N., Hansen, M. L., Hansen, A. E., Deacon, Carolyn F., Hartmann, Bolette, Keller, S. H., Loft, A., Kjær, Andreas, Madsbad, Sten, Lofgren, J., Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2020, In: Diabetologia. 63, SUPPL 1, p. S216-S217 442.

    Research output: Contribution to journalConference abstract in journalResearch

  94. Published

    No effects of a 6-week intervention with a glucagon-like peptide-1 receptor agonist on pancreatic volume and oedema in obese men without diabetes

    Svane, M. S., Johannesen, H. H., Martinussen, C., Bojsen-Moller, K. N., Hansen, M. L., Hansen, Adam Espe, Deacon, Carolyn F., Hartmann, Bolette, Keller, S. H., Klausen, T. L., Loft, A., Kjær, Andreas, Madsbad, Sten, Lofgren, J., Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2020, In: Diabetes, Obesity and Metabolism. 22, 10, p. 1837-1846

    Research output: Contribution to journalJournal articleResearchpeer-review

  95. E-pub ahead of print

    Neurotensin secretion after Roux-en-Y gastric bypass, sleeve gastrectomy, and truncal vagotomy with pyloroplasty

    Svane, M. S., Øhrstrøm, C. C., Plamboeck, A., Jørgensen, N. B., Bojsen-Møller, K. N., Dirksen, C., Martinussen, C., Vilsbøll, Tina, Hartmann, Bolette, Deacon, Carolyn F., Kristiansen, V. B., Knop, F. K., Svendsen, L. B., Madsbad, Sten, Holst, Jens Juul & Veedfald, Simon, Aug 2021, (E-pub ahead of print) In: Neurogastroenterology and Motility. e14210.

    Research output: Contribution to journalJournal articleResearchpeer-review

  96. Published

    Endogenous GLP-1 mediates postprandial reductions in activation in central reward and satiety areas in patients with type 2 diabetes

    Ten Kulve, J. S., Veltman, D. J., van Bloemendaal, L., Barkhof, F., Deacon, Carolyn F., Holst, Jens Juul, Konrad, R. J., Sloan, J. H., Drent, M. L., Diamant, M. & IJzerman, R. G., Dec 2015, In: Diabetologia. 58, 12, p. 2688-98 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  97. Published

    Elevated Postoperative Endogenous GLP-1 Levels Mediate Effects of Roux-en-Y Gastric Bypass on Neural Responsivity to Food Cues

    Ten Kulve, J. S., Veltman, D. J., Gerdes, V. E. A., van Bloemendaal, L., Barkhof, F., Deacon, Carolyn F., Holst, Jens Juul, Drent, M. L., Diamant, M. & IJzerman, R. G., Nov 2017, In: Diabetes Care. 40, 11, p. 1522-1529 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  98. Published

    Effects of Pioglitazone on Glucose-Dependent Insulinotropic Polypeptide-Mediated Insulin Secretion and Adipocyte Receptor Expression in Patients With Type 2 Diabetes

    Tharp, W. G., Gupta, D., Sideleva, O., Deacon, Carolyn F., Holst, Jens Juul, Elahi, D. & Pratley, R. E., 2020, In: Diabetes. 69, 2, p. 146-157

    Research output: Contribution to journalJournal articleResearchpeer-review

  99. Published

    The clinical effects of a carbohydrate-reduced high-protein diet on glycaemic variability in metformin-treated patients with type 2 diabetes mellitus: A randomised controlled study

    Thomsen, Mads Norvin, Skytte, M. J., Astrup, Arne, Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten, Krarup, T., Haugaard, Steen Bendix & Samkani, A., 2020, In: Clinical Nutrition ESPEN. 39, p. 46-52 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  100. Published

    Neutral endopeptidase 24.11 is important for the degradation of both endogenous and exogenous glucagon in anesthetized pigs.

    Trebbien, R., Klarskov, L., Olesen, M., Holst, Jens Juul, Carr, R. D. & Deacon, Carolyn F., 2004, In: American Journal of Physiology: Endocrinology and Metabolism. 287, 3, p. E431-8

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 9220