Carolyn F. Deacon
Carolyn F. Deacon

Associate Professor


  1. 2019
  2. Published

    Effects of Acute GLP-1 Infusion on Pulmonary and Systemic Hemodynamics in Patients With Heart Failure: A Pilot Study

    Clarke, S. J., Pettit, S., Giblett, J. P., Zhao, T., Kydd, A. C., Albrechtsen, Nicolai Jacob Wewer, Deacon, Carolyn F., Parameshwar, J. & Hoole, S. P., 2019, In : Clinical Therapeutics. 41, 1, p. 118-127 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Physiology and Pharmacology of DPP-4 in Glucose Homeostasis and the Treatment of Type 2 Diabetes

    Deacon, Carolyn F., 2019, In : Frontiers in Endocrinology. 10, 14 p., 80.

    Research output: Contribution to journalReviewResearchpeer-review

  4. Published

    Paracrine Crosstalk between Intestinal L- and D-cells Controls Secretion of Glucagon-Like Peptide-1 in mice

    Jepsen, Sara Lind, Grunddal, Kaare Villum, Albrechtsen, Nicolai Jacob Wewer, Engelstoft, M. S., Gabe, Maria Buur Nordskov, Jensen, E. P., Ørskov, Cathrine, Poulsen, Steen Seier, Rosenkilde, M. M., Pedersen, J., Gribble, F. M., Reimann, F., Deacon, Carolyn F., Schwartz, Thue W., Christ, A. D., Martin, R. E. & Holst, Jens Juul, 2019, In : American Journal of Physiology: Endocrinology and Metabolism. 317, 6, p. E1081-E1093

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Sacubitril/Valsartan Augments Postprandial Plasma Concentrations of Active GLP-1 When Combined With Sitagliptin in Men

    Albrechtsen, Nicolai Jacob Wewer, Mark, P. D., Terzic, D., Hansen, L. H., Andersen, U. Ø., Hartmann, Bolette, Carr, R. D., Gustafsson, Finn, Deacon, Carolyn F., Holst, Jens Juul, Goetze, Jens P. & Plomgaard, Peter Stendahl, 2019, In : Journal of Clinical Endocrinology and Metabolism. 104, 9, p. 3868-3876

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2018
  7. Published

    Do we know the true mechanism of action of the DPP-4 inhibitors?

    Andersen, E. S., Deacon, Carolyn F. & Holst, Jens Juul, 2018, In : Diabetes, Obesity and Metabolism. 20, 1, p. 34-41 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Is glucagon‐like peptide‐1 fully protected by the dipeptidyl peptidase 4 inhibitor sitagliptin when administered to patients with type 2 diabetes?

    Andersen, E. S., Lund, A., Bagger, J. I., Andreasen, C., Grøndahl, M., Deacon, Carolyn F., Hartmann, Bolette, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, Aug 2018, In : Diabetes, Obesity and Metabolism. 20, 8, p. 1937-1943

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Acute administration of interleukin-6 does not increase secretion of glucagon-like peptide-1 in mice

    Christiansen, Charlotte Bayer, Jepsen, Sara Lind, Svendsen, Berit, Balk-Møller, E., Dahlby, T., Kuhre, Rune Ehrenreich, Hartmann, Bolette, Mandrup-Poulsen, Thomas, Deacon, Carolyn F., Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2018, In : Physiological Reports. 6, 13, p. 1-8 e13788.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    GLP-1 Is a Coronary Artery Vasodilator in Humans

    Clarke, S. J., Giblett, J. P., Yang, L. L., Hubsch, A., Zhao, T., Aetesam-ur-Rahman, M., West, N. E. J., O'Sullivan, M., Figg, N., Bennett, M., Albrechtsen, Nicolai Jacob Wewer, Deacon, Carolyn F., Cheriyan, J. & Hoole, S. P., 20 Nov 2018, In : Journal of the American Heart Association. 7, 22, 14 p., e010321.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    A review of dipeptidyl peptidase-4 inhibitors: Hot topics from randomized controlled trials

    Deacon, Carolyn F., Feb 2018, In : Diabetes, Obesity and Metabolism. 20, p. 34-46 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  12. Published

    Peptide degradation and the role of DPP-4 inhibitors in the treatment of type 2 diabetes

    Deacon, Carolyn F., Feb 2018, In : Peptides. 100, p. 150-157 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    A review of dipeptidyl peptidase-4 inhibitors. Hot topics from randomised controlled trials

    Deacon, Carolyn F., 2018, In : Diabetes, Obesity and Metabolism. 20, Suppl. 1, p. 34-46

    Research output: Contribution to journalReviewResearchpeer-review

  14. Published

    Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.

    Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Larsen, O., Jepsen, Sara Lind, Balk-Møller, E., Andersen, Daniel Bjørklund, Deacon, Carolyn F., Schoonjans, K., Reimann, F., Gribble, F. M., Albrechtsen, Reidar, Hartmann, Bolette, Rosenkilde, Mette & Holst, Jens Juul, 2018, In : Molecular Metabolism. 11, p. 84-95 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    A carbohydrate-reduced high-protein diet acutely decreases postprandial and diurnal glucose excursions in type 2 diabetes patients

    Samkani, A., Skytte, Mads Gustav Juul, Kandel, D., Kjaer, S., Astrup, Arne, Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten, Rehfeld, Jens Frederik, Haugaard, Steen Bendix & Krarup, T., 2018, In : British Journal of Nutrition. 119, 8, p. 910-917 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides: a randomized trial

    Samkani, A., Skytte, Mads Gustav Juul, Anholm, C., Astrup, Arne, Deacon, Carolyn F., Holst, Jens Juul, Madsbad, S., Boston, R., Krarup, T. & Haugaard, Steen Bendix, 2018, In : Lipids in Health and Disease. 17, 9 p., 295.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Acute Effects of Dietary Carbohydrate Restriction on Glycemia, Lipemia and Appetite Regulating Hormones in Normal-Weight to Obese Subjects

    Samkani, A. A., Skytte, Mads Gustav Juul, Thomsen, M. N., Astrup, Arne, Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten, Rehfeld, Jens Frederik, Krarup, T. & Haugaard, Steen Bendix, Sep 2018, In : Nutrients. 10, 9, p. 1-14 14 p., 1285.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Ghrelin secretion in humans - a role for the vagus nerve?

    Veedfald, Simon, Plamboeck, A., Hartmann, Bolette, Vilsbøll, Tina, Knop, Filip Krag, Deacon, Carolyn F., Svendsen, Lars Bo & Holst, Jens Juul, Jun 2018, In : Neurogastroenterology and Motility. 30, 6, e13295.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Hyperosmolar Duodenal Saline Infusion Lowers Circulating Ghrelin and Stimulates Intestinal Hormone Release in Young Men

    Veedfald, Simon, Wu, T., Bound, M., Grivell, J., Hartmann, Bolette, Rehfeld, Jens Frederik, Deacon, Carolyn F., Horowitz, M., Holst, Jens Juul & Rayner, C. K., 2018, In : Journal of Clinical Endocrinology & Metabolism. 103, 12, p. 4409-4418

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. 2017
  21. Published

    Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production

    Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Hornburg, D., Jensen, C. Z., Hornum, Mads, Dirksen, C., Svane, M., Gasbjerg, L. S., Jorgensen, N. B., Gabe, Maria Buur Nordskov, Balk-Moller, E., Albrechtsen, Reidar, Winther-Sørensen, Marie, Galsgaard, Katrine Douglas, Meissner, F., Jorsal, T., Lund, A., Vilsbøll, Tina, Eliasen, R., Bojsen-Moller, K. N., Idorn, T., Deacon, Carolyn F., Knop, Filip Krag, Rosenkilde, Mette, Hartmann, Bolette, Feldt-Rasmussen, Bo, Mann, Matthias, Madsbad, Sten & Holst, Jens Juul, Nov 2017, In : Cell Reports. 21, 6, p. 1452-1460

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Critical role for GLP-1 in symptomatic post-bariatric hypoglycaemia

    Craig, C. M., Liu, L., Deacon, Carolyn F., Holst, Jens Juul & McLaughlin, T. L., Mar 2017, In : Diabetologia. 60, 3, p. 531-540

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Difference in postprandial GLP-1 response despite similar glucose kinetics after consumption of wheat breads with different particle size in healthy men

    Eelderink, C., Noort, M. W. J., Sozer, N., Koehorst, M., Holst, Jens Juul, Deacon, Carolyn F., Rehfeld, Jens Frederik, Poutanen, K., Vonk, R. J., Oudhuis, L. & Priebe, M. G., 2017, In : European Journal of Nutrition. 56, 3, p. 1063-1076 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Fructose intervention for 12 weeks does not impair glycemic control or incretin hormone responses during oral glucose or mixed meal tests in obese men

    Matikainen, N., Söderlund, S., Björnson, E., Bogl, L. H., Pietiläinen, K. H., Hakkarainen, A., Lundbom, N., Eliasson, B., Räsänen, S. M., Rivellese, A., Patti, L., Prinster, A., Riccardi, G., Després, J., Alméras, N., Holst, Jens Juul, Deacon, Carolyn F., Borén, J. & Taskinen, M., Jun 2017, In : Nutrition, Metabolism & Cardiovascular Diseases. 27, 6, p. 534-542 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Addition of a dipeptidyl peptidase-4 inhibitor, sitagliptin, to ongoing therapy with the glucagon-like peptide-1 receptor agonist liraglutide: A randomized controlled trial in patients with type 2 diabetes

    Nauck, M. A., Kahle, M., Baranov, O., Deacon, Carolyn F. & Holst, Jens Juul, 6 Feb 2017, In : Diabetes, Obesity and Metabolism. 19, 2, p. 200-207 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Elevated Postoperative Endogenous GLP-1 Levels Mediate Effects of Roux-en-Y Gastric Bypass on Neural Responsivity to Food Cues

    Ten Kulve, J. S., Veltman, D. J., Gerdes, V. E. A., van Bloemendaal, L., Barkhof, F., Deacon, Carolyn F., Holst, Jens Juul, Drent, M. L., Diamant, M. & IJzerman, R. G., Nov 2017, In : Diabetes Care. 40, 11, p. 1522-1529 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    A sandwich ELISA for measurement of the primary glucagon-like peptide-1 metabolite

    Albrechtsen, Nicolai Jacob Wewer, Asmar, A., Jensen, F., Törang, S., Simonsen, L., Kuhre, Rune Ehrenreich, Asmar, M., Veedfald, Simon, Plamboeck, A., Knop, Filip Krag, Vilsbøll, Tina, Madsbad, Sten, Nauck, M. A., Deacon, Carolyn F., Bülow, Jens, Holst, Jens Juul & Hartmann, Bolette, 1 Sep 2017, In : American Journal of Physiology: Endocrinology and Metabolism. 313, 3, p. E284-E291

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Why is it so difficult to measure glucagon-like peptide-1 in a mouse?

    Windeløv, J. A., Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Jepsen, Sara Lind, Hornburg, D., Pedersen, J., Jensen, E. P., Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Ørgaard, A., Deacon, Carolyn F., Mann, Matthias, Kissow, Hannelouise, Hartmann, Bolette & Holst, Jens Juul, Oct 2017, In : Diabetologia. 60, 10, p. 2066-2075 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. 2016
  30. Published

    Dynamics of glucagon secretion in mice and rats revealed using a validated sandwich ELISA for small sample volumes.

    Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Windeløv, J. A., Ørgaard, A., Deacon, Carolyn F., Kissow, Hannelouise, Hartmann, Bolette & Holst, Jens Juul, 2016, In : American Journal of Physiology: Endocrinology and Metabolism. 311, 2, p. E302-E309 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published
  32. Published

    Feedback suppression of meal-induced glucagon-like peptide-1 (GLP-1) secretion mediated through elevations in intact GLP-1 caused by dipeptidyl peptidase-4 inhibition: a randomized, prospective comparison of sitagliptin and vildagliptin treatment

    Baranov, O., Kahle, M., Deacon, Carolyn F., Holst, Jens Juul & Nauck, M. A., Nov 2016, In : Diabetes, Obesity and Metabolism. 18, 11, p. 1100-1109 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    A comparative review of DPP-4 inhibitors and sulphonylureas

    Deacon, Carolyn F. & Lebovitz, H., 2016, In : Diabetes, Obesity and Metabolism. 18, p. 333-347

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Comparative review of dipeptidyl peptidase-4 inhibitors and sulphonylureas.

    Deacon, Carolyn F. & Lebovitz, H., 2016, In : Diabetes, Obesity and Metabolism. 18, 4, p. 333-347 15 p.

    Research output: Contribution to journalReviewResearchpeer-review

  35. Published

    DPP-4 inhibitors

    Deacon, Carolyn F., 2016, Handbook of incretin therapies in type 2 diabetes. Gough, S. (ed.). Switzerland: Springer, p. 45-60

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  36. Published

    Peptide production and secretion in GLUTag, NCI-H716 and STC-1 cells: a comparison to native L-cells.

    Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Deacon, Carolyn F., Balk-Møller, E., Rehfeld, Jens Frederik, Relman, F., Gribble, F. M. & Holst, Jens Juul, 2016, In : Journal of Molecular Endocrinology. 56, p. 201-211

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Pancreatic α-cell hyperplasia and hyperglucagonemia due to a mutation of the glucagon

    Larger, E., Albrechtsen, Nicolai Jacob Wewer, Hansen, L. H., Gelling, R. W., Capeau, J., Deacon, Carolyn F., Madsen, O. D., Yakushiji, F., Meyts, P. D., Holst, Jens Juul & Nishimura, E., 2016, In : Endocrinology, Diabetes & Metabolism Case Reports. 2016, 6 p., EDM160081.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men

    Matikainen, N., Björnson, E., Söderlund, S., Borén, C., Eliasson, B., Pietiläinen, K. H., Bogl, L. H., Hakkarainen, A., Lundbom, N., Rivellese, A., Riccardi, G., Després, J., Alméras, N., Holst, Jens Juul, Deacon, Carolyn F., Borén, J. & Taskinen, M., 2016, In : PLOS ONE. 11, 1, p. 1-15 15 p., e0145890.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Quantification of the contribution of GLP-1 to mediating insulinotropic effects of DPP-4 inhibition with vildagliptin in healthy subjects and type 2-diabetic patients using exendin [9-39] as a GLP-1 receptor antagonist.

    Nauck, M. A., Kind, J., Köthe, L. D., Holst, Jens Juul, Deacon, Carolyn F., Broschag, M., He, Y., Kjems, L. & Foley, J., 2016, In : Diabetes. 65, 8, p. 2440-2447 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Cephalic phase secretion of insulin and other enteropancreatic hormones in humans

    Veedfald, Simon, Plamboeck, A., Deacon, Carolyn F., Hartmann, Bolette, Knop, Filip Krag, Vilsbøll, Tina & Holst, Jens Juul, 1 Jan 2016, In : American Journal of Physiology: Gastrointestinal and Liver Physiology. 310, 1, p. G43-51

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    The insulinotropic effect of exogenous GLP-1 is not affected by acute vagotomy in anaesthetized pigs

    Veedfald, Simon, Hansen, Marie, Christensen, L. W., Larsen, S. A. H., Hjøllund, K. R., Plamboeck, A., Hartmann, Bolette, Deacon, Carolyn F. & Holst, Jens Juul, 30 Mar 2016, In : Experimental Physiology. 101, 7, p. 895-912 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Inability of Some Commercial Assays to Measure Suppression of Glucagon Secretion

    Albrechtsen, Nicolai Jacob Wewer, Veedfald, Simon, Plamboeck, A., Deacon, Carolyn F., Hartmann, Bolette, Knop, Filip Krag, Vilsbøll, Tina & Holst, Jens Juul, 2016, In : Journal of Diabetes Research. 2016, 5 p., 8352957.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published
  44. Published

    A Protein Preload Enhances the Glucose-Lowering Efficacy of Vildagliptin in Type 2 Diabetes

    Wu, T., Little, T., Bound, M., Borg, M., Zhang, X., Deacon, Carolyn F., Horowitz, M., Jones, K. & Rayner, C., 2016, In : Diabetes Care. 39, 4, p. 511-517 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Small intestinal glucose delivery affects the glucose-lowering effect of acute vildagliptin in type 2 diabetes

    Wu, T., Zhang, X., Trahair, L., Bound, M., Little, T., Deacon, Carolyn F., Horowitz, M., Jones, K. & Rayner, C., 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 12, p. 4769-4778

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. 2015
  47. Published

    Restoration of the insulinotropic effect of glucose-dependent insulinotropic polypeptide contributes to the antidiabetic effect of dipeptidyl peptidase-4 inhibitors

    Aaboe, K., Akram, S., Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten & Krarup, T., Jan 2015, In : Diabetes, Obesity and Metabolism. 17, 1, p. 74-81 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Stability of glucagon-like peptide-1 and glucagon in human plasma

    Albrechtsen, Nicolai Jacob Wewer, Bak, M. J., Hartmann, Bolette, Christensen, L. W., Kuhre, Rune Ehrenreich, Deacon, Carolyn F. & Holst, Jens Juul, 16 Jan 2015, In : Endocrine Connections. 4, 1, p. 50-57 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    The Use of Gastrostomy Tube for the Long-Term Remission of Hyperinsulinemic Hypoglycemia After Roux-en-y Gastric Bypass: A Case Report

    Craig, C., Lamendola, C., Holst, Jens Juul, Deacon, Carolyn F. & McLaughlin, T., 2015, In : aace clinical case reports. 1, 2, p. e84-e87 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    The structure of wheat bread influences the postprandial metabolic response in healthy men

    Eelderink, C., Noort, M. W. J., Sozer, N., Koehorst, M., Holst, Jens Juul, Deacon, Carolyn F., Rehfeld, Jens Frederik, Poutanen, K., Vonk, R. J., Oudhuis, L. & Priebe, M. G., Oct 2015, In : Food & Function. 6, 10, p. 3236-48 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Important species differences regarding lymph contribution to gut hormone responses

    Hansen, Marie, Hjøllund, K. R., Hartmann, Bolette, Plamboeck, A., Deacon, Carolyn F., Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, Sep 2015, In : Peptides. 71, p. 28-31 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Activation of GLP-1 receptors on vascular smooth muscle cells reduces the autoregulatory response in afferent arterioles and increases renal blood flow

    Jensen, E. P., Poulsen, Steen Seier, Kissow, Hannelouise, Holstein-Rathlou, N., Deacon, Carolyn F., Jensen, B. L., Holst, Jens Juul & Sorensen, Charlotte Mehlin, 15 Apr 2015, In : A J P: Renal Physiology (Online). 308, 8, p. F867-F877 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Measurement of the incretin hormones: glucagon-like peptide-1 and glucose-dependent insulinotropic peptide

    Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Hartmann, Bolette, Deacon, Carolyn F. & Holst, Jens Juul, Apr 2015, In : Journal of Diabetes and its Complications. 29, 3, p. 445-450 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Incretin effect after oral amino Acid ingestion in humans

    Lindgren, O., Pacini, G., Tura, A., Holst, Jens Juul, Deacon, Carolyn F. & Ahrén, B., Mar 2015, In : The Journal of clinical endocrinology and metabolism. 100, 3, p. 1172-6 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    The role of efferent cholinergic transmission for the insulinotropic and glucagonostatic effects of GLP-1

    Plamboeck, A., Veedfald, Simon, Deacon, Carolyn F., Hartmann, Bolette, Vilsbøll, T., Knop, Filip Krag & Holst, Jens Juul, Sep 2015, In : American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 309, 5, p. R544-51 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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