Carolyn F. Deacon

Carolyn F. Deacon

Associate Professor


  1. 2019
  2. E-pub ahead of print

    Paracrine Crosstalk between Intestinal L- and D-cells Controls Secretion of Glucagon-Like Peptide-1 in mice. / Jepsen, Sara L.; Grunddal, Kaare V.; Wewer Albrechtsen, Nicolai J; Engelstoft, Maja S; Gabe, Maria B N; Jensen, Elisa P; Ørskov, Cathrine; Poulsen, Steen S; Rosenkilde, Mette M; Pedersen, Jens; Gribble, Fiona M; Reimann, Frank; Deacon, Carolyn F; Schwartz, Thue W; Christ, Andreas D; Martin, Rainer E; Holst, Jens J.

    In: A J P: Endocrinology and Metabolism (Online), 10.09.2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Effects of Acute GLP-1 Infusion on Pulmonary and Systemic Hemodynamics in Patients With Heart Failure : A Pilot Study. / Clarke, Sophie J.; Pettit, Stephen; Giblett, Joel P.; Zhao, Tian; Kydd, Anna C.; Albrechtsen, Nicolai J. W.; Deacon, Carolyn F.; Parameshwar, Jayan; Hoole, Stephen P.

    In: Clinical Therapeutics, Vol. 41, No. 1, 2019, p. 118-127.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Physiology and Pharmacology of DPP-4 in Glucose Homeostasis and the Treatment of Type 2 Diabetes. / Deacon, Carolyn F.

    In: Frontiers in Endocrinology, Vol. 10, 80, 2019.

    Research output: Contribution to journalReviewResearchpeer-review

  5. Published

    Sacubitril/Valsartan Augments Postprandial Plasma Concentrations of Active GLP-1 When Combined With Sitagliptin in Men. / Wewer Albrechtsen, Nicolai J; Mark, Peter D; Terzic, Dijana; Hansen, Lasse H; Andersen, Ulrik Ø; Hartmann, Bolette; Carr, Richard D; Gustafsson, Finn; Deacon, Carolyn F; Holst, Jens J; Goetze, Jens P; Plomgaard, Peter.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 104, No. 9, 2019, p. 3868-3876.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2018
  7. Published

    GLP-1 Is a Coronary Artery Vasodilator in Humans. / Clarke, Sophie J.; Giblett, Joel P.; Yang, Lucy L.; Hubsch, Annette; Zhao, Tian; Aetesam-ur-Rahman, Muhammad; West, Nick E. J.; O'Sullivan, Michael; Figg, Nichola; Bennett, Martin; Albrechtsen, Nicolai J. Wewer; Deacon, Carolyn F.; Cheriyan, Joseph; Hoole, Stephen P.

    In: Journal of the American Heart Association, Vol. 7, No. 22, e010321, 20.11.2018.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Acute Effects of Dietary Carbohydrate Restriction on Glycemia, Lipemia and Appetite Regulating Hormones in Normal-Weight to Obese Subjects. / Samkani, Amirsalar Agertoft; Skytte, Mads J; Thomsen, Mads N; Astrup, Arne; Deacon, Carolyn F; Holst, Jens Juul; Madsbad, Sten; Rehfeld, Jens Frederik; Krarup, Thure; Haugaard, Steen B.

    In: Nutrients, Vol. 10, No. 9, 1285, 09.2018, p. 1-14.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Is glucagon‐like peptide‐1 fully protected by the dipeptidyl peptidase 4 inhibitor sitagliptin when administered to patients with type 2 diabetes? / Andersen, Emilie S.; Lund, A.; Bagger, J. I.; Andreasen, C; Grøndahl, MF; Deacon, Carolyn F.; Hartmann, Bolette; Holst, Jens Juul; Knop, Filip Krag; Lauritsen, Tina Vilsbøll.

    In: Diabetes, Obesity and Metabolism, Vol. 20, No. 8, 08.2018, p. 1937-1943.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Ghrelin secretion in humans - a role for the vagus nerve? / Veedfald, S; Plamboeck, A; Hartmann, B; Vilsbøll, T; Knop, F K; Deacon, C F; Svendsen, L B; Holst, J J.

    In: Neurogastroenterology and Motility, Vol. 30, No. 6, e13295, 06.2018.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    A review of dipeptidyl peptidase-4 inhibitors : Hot topics from randomized controlled trials. / Deacon, Carolyn F.

    In: Diabetes, Obesity and Metabolism, Vol. 20, 02.2018, p. 34-46.

    Research output: Contribution to journalReviewResearchpeer-review

  12. Published

    Peptide degradation and the role of DPP-4 inhibitors in the treatment of type 2 diabetes. / Deacon, Carolyn F.

    In: Peptides, Vol. 100, 02.2018, p. 150-157.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    A carbohydrate-reduced high-protein diet acutely decreases postprandial and diurnal glucose excursions in type 2 diabetes patients. / Samkani, Amirsalar; Skytte, Mads Gustav Juul; Kandel, Daniel; Kjaer, Stine; Astrup, Arne; Deacon, Carolyn F.; Holst, Jens J; Madsbad, Sten; Rehfeld, Jens Frederik; Haugaard, Steen Bendix; Krarup, Thure.

    In: British Journal of Nutrition, Vol. 119, No. 8, 2018, p. 910-917.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    A review of dipeptidyl peptidase-4 inhibitors. Hot topics from randomised controlled trials. / Deacon, Carolyn F.

    In: Diabetes, Obesity and Metabolism, Vol. 20, No. Suppl. 1, 2018, p. 34-46.

    Research output: Contribution to journalReviewResearchpeer-review

  15. Published

    Acute administration of interleukin-6 does not increase secretion of glucagon-like peptide-1 in mice. / Christiansen, Charlotte B.; Lind, Sara J.; Svendsen, Berit; Balk-Møller, Emilie; Dahlby, Tina; Kuhre, Rune E; Hartmann, Bolette; Mandrup-Poulsen, Thomas; Deacon, Carolyn F; Albrechtsen, Nicolai J. Wewer; Holst, Jens J.

    In: Physiological Reports, Vol. 6, No. 13, e13788, 2018, p. 1-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published
  17. Published

    Do we know the true mechanism of action of the DPP-4 inhibitors? / Andersen, Emilie S.; Deacon, Carolyn F.; Holst, Jens Juul.

    In: Diabetes, Obesity and Metabolism, Vol. 20, No. 1, 2018, p. 34-41.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Hyperosmolar Duodenal Saline Infusion Lowers Circulating Ghrelin and Stimulates Intestinal Hormone Release in Young Men. / Veedfald, Simon; Wu, Tongzhi; Bound, Michelle; Grivell, Jacqueline; Hartmann, Bolette; Rehfeld, Jens F.; Deacon, Carolyn F.; Horowitz, Michael; Holst, Jens J.; Rayner, Christopher K.

    In: Journal of Clinical Endocrinology & Metabolism, Vol. 103, No. 12, 2018, p. 4409-4418.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides : a randomized trial. / Samkani, Amirsalar; Skytte, Mads Gustav Juul; Anholm, Christian; Astrup, Arne; Deacon, Carolyn F; Holst, Jens Juul; Madsbad, Sten; Boston, Ray; Krarup, Thure; Haugaard, Steen B.

    In: Lipids in Health and Disease, Vol. 17, 295, 2018.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. 2017
  21. Published

    Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production. / Albrechtsen, Nicolai J. Wewer; Kuhre, Rune E.; Hornburg, Daniel; Jensen, Christian Z.; Hornum, Mads; Dirksen, Carsten; Svane, Maria; Gasbjerg, Laerke S.; Jorgensen, Nils B.; Gabe, Maria N.; Balk-Moller, Emilie; Albrechtsen, Reidar; Winther-Sorensen, Marie; Galsgaard, Katrine D.; Meissner, Felix; Jorsal, Tina; Lund, Asger; Vilsboll, Tina; Eliasen, Rasmus; Bojsen-Moller, Kirstine N.; Idorn, Thomas; Deacon, Carolyn F.; Knop, Filip K.; Rosenkilde, Mette M.; Hartmann, Bolette; Feldt-Rasmussen, Bo; Mann, Matthias; Madsbad, Sten; Holst, Jens J.

    In: Cell Reports, Vol. 21, No. 6, 11.2017, p. 1452-1460.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Elevated Postoperative Endogenous GLP-1 Levels Mediate Effects of Roux-en-Y Gastric Bypass on Neural Responsivity to Food Cues. / Ten Kulve, Jennifer S; Veltman, Dick J; Gerdes, Victor E A; van Bloemendaal, Liselotte; Barkhof, Frederik; Deacon, Carolyn F; Holst, Jens J; Drent, Madeleine L; Diamant, Michaela; IJzerman, Richard G.

    In: Diabetes Care, Vol. 40, No. 11, 11.2017, p. 1522-1529.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Why is it so difficult to measure glucagon-like peptide-1 in a mouse? / Windeløv, Johanne A; Wewer Albrechtsen, Nicolai J; Kuhre, Rune E; Jepsen, Sara L; Hornburg, Daniel; Pedersen, Jens; Jensen, Elisa P; Galsgaard, Katrine D; Winther-Sørensen, Marie; Ørgaard, Anne; Deacon, Carolyn F; Mann, Matthias; Kissow, Hannelouise; Hartmann, Bolette; Holst, Jens J.

    In: Diabetologia, Vol. 60, No. 10, 10.2017, p. 2066-2075.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    A sandwich ELISA for measurement of the primary glucagon-like peptide-1 metabolite. / Wewer Albrechtsen, Nicolai J; Asmar, Ali; Jensen, Frederik; Törang, Signe; Simonsen, Lene; Kuhre, Rune E; Asmar, Meena; Veedfald, Simon; Plamboeck, Astrid; Knop, Filip K; Vilsbøll, Tina; Madsbad, Sten; Nauck, Michael A; Deacon, Carolyn F; Bülow, Jens; Holst, Jens J; Hartmann, Bolette.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 313, No. 3, 01.09.2017, p. E284-E291.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Fructose intervention for 12 weeks does not impair glycemic control or incretin hormone responses during oral glucose or mixed meal tests in obese men. / Matikainen, N; Söderlund, S; Björnson, E; Bogl, L H; Pietiläinen, K H; Hakkarainen, A; Lundbom, N; Eliasson, B; Räsänen, S M; Rivellese, A; Patti, L; Prinster, A; Riccardi, G; Després, J-P; Alméras, N; Holst, J J; Deacon, C F; Borén, J; Taskinen, M-R.

    In: Nutrition, Metabolism & Cardiovascular Diseases, Vol. 27, No. 6, 06.2017, p. 534-542.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Critical role for GLP-1 in symptomatic post-bariatric hypoglycaemia. / Craig, Colleen M; Liu, Li-Fen; Deacon, Carolyn F; Holst, Jens J; McLaughlin, Tracey L.

    In: Diabetologia, Vol. 60, No. 3, 03.2017, p. 531-540.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Addition of a dipeptidyl peptidase-4 inhibitor, sitagliptin, to ongoing therapy with the glucagon-like peptide-1 receptor agonist liraglutide : A randomized controlled trial in patients with type 2 diabetes. / Nauck, Michael A; Kahle, Melanie; Baranov, Oleg; Deacon, Carolyn F; Holst, Jens J.

    In: Diabetes, Obesity and Metabolism, Vol. 19, No. 2, 06.02.2017, p. 200-207.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Difference in postprandial GLP-1 response despite similar glucose kinetics after consumption of wheat breads with different particle size in healthy men. / Eelderink, Coby; Noort, Martijn W J; Sozer, Nesli; Koehorst, Martijn; Holst, Jens J; Deacon, Carolyn F; Rehfeld, Jens F; Poutanen, Kaisa; Vonk, Roel J; Oudhuis, Lizette; Priebe, Marion G.

    In: European Journal of Nutrition, Vol. 56, No. 3, 2017, p. 1063-1076.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. 2016
  30. Published

    Feedback suppression of meal-induced glucagon-like peptide-1 (GLP-1) secretion mediated through elevations in intact GLP-1 caused by dipeptidyl peptidase-4 inhibition : a randomized, prospective comparison of sitagliptin and vildagliptin treatment. / Baranov, Oleg; Kahle, Melanie; Deacon, Carolyn F; Holst, Jens J; Nauck, Michael A.

    In: Diabetes, Obesity and Metabolism, Vol. 18, No. 11, 11.2016, p. 1100-1109.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published
  32. Published

    The insulinotropic effect of exogenous GLP-1 is not affected by acute vagotomy in anaesthetized pigs. / Veedfald, Simon; Hansen, Marie; Christensen, Louise Wulff; Larsen, Sara Agnete Hjort; Hjøllund, Karina Rahr; Plamboeck, Astrid; Hartmann, Bolette; Deacon, Carolyn F; Holst, Jens Juul.

    In: Experimental Physiology, Vol. 101, No. 7, 30.03.2016, p. 895-912.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Cephalic phase secretion of insulin and other enteropancreatic hormones in humans. / Veedfald, Simon; Plamboeck, Astrid; Deacon, Carolyn F; Hartmann, Bolette; Knop, Filip K; Lauritsen, Tina Vilsbøll; Holst, Jens J.

    In: American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol. 310, No. 1, 01.01.2016, p. G43-51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    A Protein Preload Enhances the Glucose-Lowering Efficacy of Vildagliptin in Type 2 Diabetes. / Wu, T; Little, TL; Bound, MJ; Borg, M; Zhang, X; Deacon, Carolyn F.; Horowitz, Michael; Jones, KL; Rayner, CK.

    In: Diabetes Care, Vol. 39, No. 4, 2016, p. 511-517.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    A comparative review of DPP-4 inhibitors and sulphonylureas. / Deacon, Carolyn F.; Lebovitz, HE.

    In: Diabetes, Obesity and Metabolism, Vol. 18, 2016, p. 333-347.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Comparative review of dipeptidyl peptidase-4 inhibitors and sulphonylureas. / Deacon, Carolyn F.; Lebovitz, HE.

    In: Diabetes, Obesity and Metabolism, Vol. 18, No. 4, 2016, p. 333-347.

    Research output: Contribution to journalReviewResearchpeer-review

  37. Published

    Dynamics of glucagon secretion in mice and rats revealed using a validated sandwich ELISA for small sample volumes. / Albrechtsen, Nicolai Jacob Wewer; Kuhre, Rune Ehrenreich; Windeløv, Johanne Agerlin; Ørgaard, Anne; Deacon, Carolyn F.; Kissow, Hannelouise; Hartmann, Bolette; Holst, Jens Juul.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 311, No. 2, 2016, p. E302-E309.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published
  39. Published

    Inability of Some Commercial Assays to Measure Suppression of Glucagon Secretion. / Wewer Albrechtsen, Nicolai J; Veedfald, Simon; Plamboeck, Astrid; Deacon, Carolyn F; Hartmann, Bolette; Knop, Filip K; Lauritsen, Tina Vilsbøll; Holst, Jens J.

    In: Journal of Diabetes Research, Vol. 2016, 8352957, 2016.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men. / Matikainen, Niina; Björnson, Elias; Söderlund, Sanni; Borén, Christofer; Eliasson, Björn; Pietiläinen, Kirsi H; Bogl, Leonie H; Hakkarainen, Antti; Lundbom, Nina; Rivellese, Angela; Riccardi, Gabriele; Després, Jean-Pierre; Alméras, Natalie; Holst, Jens Juul; Deacon, Carolyn F; Borén, Jan; Taskinen, Marja-Riitta.

    In: PLOS ONE, Vol. 11, No. 1, e0145890, 2016, p. 1-15.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Pancreatic α-cell hyperplasia and hyperglucagonemia due to a mutation of the glucagon. / Larger, Etienne; Albrechtsen, Nicolai Jacob Wewer; Hansen, L.H.; Gelling, R.W.; Capeau, Jaqueline; Deacon, Carolyn F.; Madsen, O.D.; Yakushiji, F; Meyts, P. De; Holst, Jens Juul; Nishimura, Erica.

    In: Endocrinology, Diabetes & Metabolism Case Reports, Vol. 2016, EDM160081, 2016.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Peptide production and secretion in GLUTag, NCI-H716 and STC-1 cells: a comparison to native L-cells. / Kuhre, Rune Ehrenreich; Albrechtsen, Nicolai Jacob Wewer; Deacon, Carolyn F.; Balk-Møller, Emilie; Rehfeld, Jens Frederik; Relman, Frank; Gribble, Fiona Mary; Holst, Jens Juul.

    In: Journal of Molecular Endocrinology, Vol. 56, 2016, p. 201-211.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Quantification of the contribution of GLP-1 to mediating insulinotropic effects of DPP-4 inhibition with vildagliptin in healthy subjects and type 2-diabetic patients using exendin [9-39] as a GLP-1 receptor antagonist. / Nauck, Michael A; Kind, J; Köthe, Lars D; Holst, Jens Juul; Deacon, Carolyn F.; Broschag, M; He, YL; Kjems, L; Foley, J.

    In: Diabetes, Vol. 65, No. 8, 2016, p. 2440-2447.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Small intestinal glucose delivery affects the glucose-lowering effect of acute vildagliptin in type 2 diabetes. / Wu, T; Zhang, X; Trahair, LG; Bound, MJ; Little, TL; Deacon, Carolyn F.; Horowitz, M; Jones, KL; Rayner, CK.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 101, No. 12, 2016, p. 4769-4778.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. 2015
  46. Published

    Endogenous GLP-1 mediates postprandial reductions in activation in central reward and satiety areas in patients with type 2 diabetes. / Ten Kulve, Jennifer S; Veltman, Dick J; van Bloemendaal, Liselotte; Barkhof, Frederik; Deacon, Carolyn F; Holst, Jens J; Konrad, Robert J; Sloan, John H; Drent, Madeleine L; Diamant, Michaela; IJzerman, Richard G.

    In: Diabetologia, Vol. 58, No. 12, 12.2015, p. 2688-98.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    The structure of wheat bread influences the postprandial metabolic response in healthy men. / Eelderink, Coby; Noort, Martijn W J; Sozer, Nesli; Koehorst, Martijn; Holst, Jens J; Deacon, Carolyn F; Rehfeld, Jens F; Poutanen, Kaisa; Vonk, Roel J; Oudhuis, Lizette; Priebe, Marion G.

    In: Food & Function, Vol. 6, No. 10, 10.2015, p. 3236-48.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Important species differences regarding lymph contribution to gut hormone responses. / Hansen, Marie; Hjøllund, Karina R; Hartmann, Bolette; Plamboeck, Astrid; Deacon, Carolyn F; Albrechtsen, Nicolai Jacob Wewer; Holst, Jens J.

    In: Peptides, Vol. 71, 09.2015, p. 28-31.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    The role of efferent cholinergic transmission for the insulinotropic and glucagonostatic effects of GLP-1. / Plamboeck, Astrid; Veedfald, Simon; Deacon, Carolyn F; Hartmann, Bolette; Vilsbøll, Tina; Knop, Filip K; Holst, Jens J.

    In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Vol. 309, No. 5, 09.2015, p. R544-51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Activation of GLP-1 receptors on vascular smooth muscle cells reduces the autoregulatory response in afferent arterioles and increases renal blood flow. / Jensen, Elisa Pouline; Poulsen, Steen Seier; Kissow, Hannelouise; Holstein-Rathlou, Niels-Henrik; Deacon, Carolyn F.; Jensen, Boye L.; Holst, Jens J.; Sorensen, Charlotte M.

    In: A J P: Renal Physiology (Online), Vol. 308, No. 8, 15.04.2015, p. F867-F877.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Measurement of the incretin hormones : glucagon-like peptide-1 and glucose-dependent insulinotropic peptide. / Kuhre, Rune Ehrenreich; Wewer Albrechtsen, Nicolai Jacob; Hartmann, Bolette; Deacon, Carolyn F.; Holst, Jens Juul.

    In: Journal of Diabetes and its Complications, Vol. 29, No. 3, 04.2015, p. 445-450.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Incretin effect after oral amino Acid ingestion in humans. / Lindgren, Ola; Pacini, Giovanni; Tura, Andrea; Holst, Jens Juul; Deacon, Carolyn F; Ahrén, Bo.

    In: The Journal of clinical endocrinology and metabolism, Vol. 100, No. 3, 03.2015, p. 1172-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Stability of glucagon-like peptide-1 and glucagon in human plasma. / Albrechtsen, Nicolai Jacob Wewer; Bak, Monika Judyta; Hartmann, Bolette; Christensen, Louise Wulff; Kuhre, Rune E; Deacon, Carolyn; Holst, Jens Juul.

    In: Endocrine Connections, Vol. 4, No. 1, 16.01.2015, p. 50-57.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Restoration of the insulinotropic effect of glucose-dependent insulinotropic polypeptide contributes to the antidiabetic effect of dipeptidyl peptidase-4 inhibitors. / Aaboe, K.; Akram, S.; Deacon, C. F.; Holst, J. J.; Madsbad, S.; Krarup, T.

    In: Diabetes, Obesity and Metabolism, Vol. 17, No. 1, 01.2015, p. 74-81.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Early phase glucagon and insulin secretory abnormalities, but not incretin secretion, are similarly responsible for hyperglycemia after ingestion of nutrients. / Yabe, Daisuke; Kuroe, Akira; Watanabe, Koin; Iwasaki, Masahiro; Hamasaki, Akihiro; Hamamoto, Yoshiyuki; Harada, Norio; Yamane, Shunsuke; Lee, Soushou; Murotani, Kenta; Deacon, Carolyn F; Holst, Jens Juul; Hirano, Tsutomu; Inagaki, Nobuya; Kurose, Takeshi; Seino, Yutaka.

    In: Journal of Diabetes and its Complications, Vol. 29, 2015, p. 413-421.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Effects of sitagliptin on blood pressure and heart rate in response to intraduodenal glucose infusion in type 2 diabetes. / Wu, T; Trahair, LG; Bound, MJ; Deacon, Carolyn F.; Horowitz, M; Rayner, CK; Jones, KL.

    In: Diabetic Medicine, Vol. 32, No. 5, 2015, p. 595-600.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    The Use of Gastrostomy Tube for the Long-Term Remission of Hyperinsulinemic Hypoglycemia After Roux-en-y Gastric Bypass : A Case Report. / Craig, CM; Lamendola, C; Holst, Jens Juul; Deacon, Carolyn F.; McLaughlin, TL.

    In: aace clinical case reports, Vol. 1, No. 2, 2015, p. e84-e87.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. 2014
  59. Published

    The impact of dipeptidyl peptidase 4 inhibition on incretin effect, glucose tolerance, and gastrointestinal-mediated glucose disposal in healthy subjects. / Rhee, Nicolai Alexander; Østoft, Signe Harring; Holst, Jens Juul; Deacon, Carolyn; Vilsbøll, Tina; Knop, Filip Krag.

    In: European Journal of Endocrinology, Vol. 171, No. 3, 16.06.2014, p. 353-362.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Hyperglucagonaemia analysed by glucagon sandwich ELISA : nonspecific interference or truly elevated levels? / Albrechtsen, Nicolai Jacob Wewer; Hartmann, Bolette; Veedfald, Simon; Windeløv, Johanne A; Plamboeck, Astrid; Bojsen-Møller, Kirstine N; Idorn, Thomas; Feldt-Rasmussen, Bo; Knop, Filip K; Vilsbøll, Tina; Madsbad, Sten; Deacon, Carolyn F; Holst, Jens J.

    In: Diabetologia, Vol. 57, No. 9, 03.06.2014, p. 1919-1926.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Effects of sitagliptin and metformin treatment on incretin hormone and insulin secretory responses to oral and "isoglycemic" intravenous glucose. / Vardarli, Irfan; Arndt, Elisabeth; Deacon, Carolyn F; Holst, Jens Juul; Nauck, Michael A.

    In: Diabetes, Vol. 63, No. 2, 02.2014, p. 663-74.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    Targeting the intestinal L-cell for obesity and type 2 diabetes treatment. / Albrechtsen, Nicolai Jacob Wewer; Kuhre, Rune Ehrenreich; Deacon, Carolyn F.; Holst, Jens Juul.

    In: Expert Review of Endocrinology & Metabolism, Vol. 9, No. 1, 01.01.2014, p. 61-72.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    Effects of sitagliptin on glycemia, incretin hormones, and antropyloroduodenal motility in response to intraduodenal glucose infusion in healthy lean and obese humans, and patients with type 2 diabetes treated with or without metformin. / Wu, T; Ma, J; Bound, MJ; Checklin, H; Deacon, Carolyn F.; Jones, KI; Horowitz, M; Raynor, CK.

    In: Diabetes, Vol. 63, No. 8, 2014, p. 2776-2787.

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    Effects of sitagliptin therapy on markers of low-grade inflammation and cell adhesion molecules in patients with type 2 diabetes. / Tremblay, AJ ; Lamarche, B; Deacon, Carolyn F.; Weisnagel, SJ; Couture, P.

    In: Metabolism, Vol. 63, No. 9, 2014, p. 1141-1148.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    Effects of the dipeptidyl peptidase IV inhibitor, vildagliptin, on glycemic, gut hormone, triglyceride, energy expenditure and energy intake responses to intraduodenal fat infusion in healthy males. / Heruc, GA; Horowitz, Michael; Deacon, Carolyn F.; Feinle-Bisset, C; Rayner, CK; Luscombe-Marsh, N; Little, Tanya J.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 307, No. 9, 2014, p. E830-E837.

    Research output: Contribution to journalJournal articleResearchpeer-review

  66. Published

    No Effect of Aprotinin (Trasylol) on Degradation of Exogenous and Endogenous Glucagon in Human, Mouse and Rat Plasma. / Bak, Monika judyta; Albrechtsen, Nicolai Jacob Wewer; Hartmann, Bolette; Pedersen, Jens; Christensen, Mikkel; Vilsboll, Tina; Knop, Filip Krag; Deacon, Carolyn Fiona; Dragsted, Lars Ove; Holst, Jens Juul.

    In: Journal of Endocrinology and Diabetes, Vol. 1, No. 1, 2014, p. 1-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. Published

    Specificity and sensitivity of commercially available assays for glucagon and oxyntomodulin measurement in humans. / Bak, Monika Judyta; Wewer Albrechtsen, Nicolai Jacob; Pedersen, Jens; Hartmann, Bolette; Christensen, Mikkel; Vilsbøll, Tina; Knop, Filip Krag; Deacon, Carolyn F; Dragsted, Lars Ove; Holst, Jens Juul.

    In: European Journal of Endocrinology, Vol. 170, No. 4, 2014, p. 529-538.

    Research output: Contribution to journalJournal articleResearchpeer-review

  68. Published

    Specificity and sensitivity of commercially available assays for glucagon-like peptide-1 (GLP-1) : Implications for GLP-1 measurements in clinical studies. / Bak, Monika Judyta; Albrechtsen, Nicolai Jacob Wewer; Pedersen, Jens; Knop, Filip Krag; Vilsbøll Lauritsen, Tina; Jørgensen, Nils B; Hartmann, Bolette; Deacon, Carolyn F.; Dragsted, Lars Ove; Holst, Jens Juul.

    In: Diabetes, Obesity and Metabolism, Vol. 16, No. 11, 2014, p. 1155-1164.

    Research output: Contribution to journalJournal articleResearchpeer-review

  69. 2013
  70. Published

    Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes : comparison, efficacy and safety. / Deacon, Carolyn F; Holst, Jens Juul.

    In: Expert Opinion on Pharmacotherapy, Vol. 14, No. 15, 10.2013, p. 2047-58.

    Research output: Contribution to journalJournal articleResearchpeer-review

  71. Published

    Characterization of oral and intravenous glucose handling in truncally vagotomised subjects with pyloroplasty. / Plamboeck, Astrid; Veedfald, Simon; Deacon, Carolyn; Hartmann, Bolette; Wettergren, Andre; Svendsen, Lars Bo; Meisner, Søren; Hovendal, Claus; Knop, Filip Krag; Vilsbøll, Tina; Holst, Jens Juul.

    In: European Journal of Endocrinology, Vol. 169, 23.05.2013, p. 187-201.

    Research output: Contribution to journalJournal articleResearchpeer-review

  72. Published

    The Effect of Exogenous GLP-1 on Food Intake is Lost in Male Truncally Vagotomized Subjects with Pyloroplasty. / Plamboeck, Astrid; Veedfald, Simon; Deacon, Carolyn F; Hartmann, Bolette; Wettergren, Andre; Svendsen, Lars Bo; Meisner, Søren; Hovendahl, Claus; Vilsboll, Tina; Knop, Filip K; Holst, Jens Juul.

    In: American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol. 304, 18.04.2013, p. G1117-G1127.

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. Published

    Is there a place for incretin therapies in obesity and prediabetes? / Holst, Jens Juul; Deacon, Carolyn F.

    In: Trends in Endocrinology and Metabolism, Vol. 24, No. 3, 13.02.2013, p. 145-152.

    Research output: Contribution to journalJournal articleResearchpeer-review

  74. Published

    The C-terminal extension of exendin-4 provides additional metabolic stability when added to GLP-1, while there is minimal effect of truncating exendin-4 in anaesthetized pigs. / Simonsen, L; Holst, Jens Juul; Madsen, K; Deacon, C F.

    In: Regulatory Peptides, Vol. 181, No. 10, 10.02.2013, p. 17-21.

    Research output: Contribution to journalJournal articleResearchpeer-review

  75. Published

    Islet-cell dysfunction induced by glucocorticoid treatment : potential role for altered sympathovagal balance? / van Raalte, Daniël H; Kwa, Kelly A A; van Genugten, Renate E; Tushuizen, Maarten E; Holst, Jens Juul; Deacon, Carolyn F; Karemaker, John M; Heine, Robert J; Mari, Andrea; Diamant, Michaela.

    In: Metabolism, Vol. 62, No. 4, 2013, p. 568-577.

    Research output: Contribution to journalJournal articleResearchpeer-review

  76. 2012
  77. Published

    Linagliptin increases incretin levels, lowers glucagon, and improves glycemic control in type 2 diabetes mellitus. / Rauch, Thomas; Graefe-Mody, Ulrike; Deacon, Carolyn F; Ring, Arne; Holst, Jens Juul; Woerle, Hans-Juergen; Dugi, Klaus A; Heise, Tim.

    In: Diabetes Therapy, Vol. 3, No. 1, 11.2012, p. 10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    Commentary: Is endogenous GLP-1 the only important enhancer of glucose-induced insulin secretion in type 2 diabetes? / Deacon, Carolyn F.

    In: Diabetes, Vol. 61, No. 9, 2012, p. 2219-2220.

    Research output: Contribution to journalJournal articleResearchpeer-review

  79. Published

    Glycaemic efficacy of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors as add-on therapy to metformin in subjects with type 2 diabetes—a review and meta analysis. / Deacon, Carolyn F.; Mannucci, E; Ahren, B.

    In: Diabetes, Obesity and Metabolism Online, Vol. 14, No. 8, 2012, p. 762-767.

    Research output: Contribution to journalReviewResearchpeer-review

  80. Published

    Impaired crosstalk between pulsatile insulin and glucagon secretion in prediabetic individuals. / Rohrer, Stefan; Menge, Björn A; Grüber, Lena; Deacon, Carolyn F; Schmidt, Wolfgang E; Veldhuis, Johannes D; Holst, Jens Juul; Meier, Juris J.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 97, No. 5, 2012, p. E791-E795.

    Research output: Contribution to journalJournal articleResearchpeer-review

  81. Published

    Linagliptin, a selective DPP-4 inhibitor, inhibits DPP-4, increases incretin levels, lowers glucagon, and improves glycaemic control in patients with Type 2 diabetes. / Rauch, T; Graefe-Mody, U; Deacon, Carolyn F.; Ring, A; Holst, Jens Juul; Woerle, H-J; Dugi, KA; Heise, T.

    In: Diabetes Therapy, Vol. 3, No. 1, 2012, p. 10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  82. Published

    Potential cardiovascular effects of incretin-based therapies. / Deacon, Carolyn F.; Marx, N.

    In: Expert Review of Cardiovascular Therapy, Vol. 10, 2012, p. 337-351.

    Research output: Contribution to journalReviewResearchpeer-review

  83. Published

    The effects of sitagliptin on gastric emptying in healthy humans – a randomised controlled study. / Stevens, JE; Horowitz, M; Deacon, Carolyn F.; Nauck, M; Rayner, CK; Jones, KL.

    In: Alimentary Pharmacology and Therapeutics, Vol. 36, No. 4, 2012, p. 379-390.

    Research output: Contribution to journalJournal articleResearchpeer-review

  84. 2011
  85. Published

    Effects of short-term therapy with glibenclamide and repaglinide on incretin hormones and oxidative damage associated with postprandial hyperglycaemia in people with type 2 diabetes mellitus. / Stephens, J W; Bodvarsdottir, T B; Wareham, K; Prior, S L; Bracken, R M; Lowe, G D; Rumley, A; Dunseath, G; Luzio, S; Deacon, C F; Holst, Jens Juul; Bain, S C.

    In: Diabetes Research and Clinical Practice, Vol. 94, No. 2, 11.2011, p. 199-206.

    Research output: Contribution to journalJournal articleResearchpeer-review

  86. Published

    GLP-1 signals via ERK in peripheral nerve and prevents nerve dysfunction in diabetic mice. / Jolivalt, CG; Fineman, M; Deacon, Carolyn F.; Carr, RD; Calcutt, NA.

    In: Diabetes, Obesity and Metabolism, Vol. 13, No. 11, 11.2011, p. 990-1000.

    Research output: Contribution to journalJournal articleResearchpeer-review

  87. Published

    Incretin hormone and insulin responses to oral versus intravenous lipid administration in humans. / Lindgren, Ola; Carr, Richard D; Deacon, Carolyn F; Holst, Jens Juul; Pacini, Giovanni; Mari, Andrea; Ahrén, Bo.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 96, No. 8, 08.2011, p. 2519-2524.

    Research output: Contribution to journalJournal articleResearchpeer-review

  88. Published

    Loss of inverse relationship between pulsatile insulin and glucagon secretion in patients with type 2 diabetes. / Menge, Björn A; Grüber, Lena; Jørgensen, Signe M; Deacon, Carolyn F; Schmidt, Wolfgang E; Veldhuis, Johannes D; Holst, Jens Juul; Meier, Juris J.

    In: Diabetes, Vol. 60, No. 8, 08.2011, p. 2160-2168.

    Research output: Contribution to journalJournal articleResearchpeer-review

  89. Published

    Dissociated incretin hormone response to protein versus fat ingestion in obese subjects. / Lindgren, O; Carr, RD; Holst, Jens Juul; Deacon, Carolyn F.; Ahren, B.

    In: Diabetes, Obesity and Metabolism Online, Vol. 13, No. 9, 07.2011, p. 863-865.

    Research output: Contribution to journalJournal articleResearchpeer-review

  90. Published

    An overview of once-weekly glucagon-like peptide-1 receptor agonists--available efficacy and safety data and perspectives for the future. / Madsbad, S; Kielgast, U; Asmar, M; Deacon, C F; Torekov, Signe Sørensen; Holst, J J.

    In: Diabetes, Obesity and Metabolism, Vol. 13, No. 5, 05.2011, p. 394-407.

    Research output: Contribution to journalJournal articleResearchpeer-review

  91. Published

    Effect of Sitagliptin therapy on postprandial lipoprotein levels in patients with type 2 diabetes. / Tremblay, AJ; Lamarche, B; Deacon, Carolyn F.; Weisnagel, SJ; Couture, P.

    In: Diabetes, Obesity and Metabolism, Vol. 13, No. 4, 04.2011, p. 366-373.

    Research output: Contribution to journalJournal articleResearchpeer-review

  92. Published
  93. Published

    Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: A comparative review. / Deacon, Carolyn F.

    In: Diabetes, Obesity and Metabolism, Vol. 13, No. 1, 01.2011, p. 7-18.

    Research output: Contribution to journalReviewResearchpeer-review

  94. Published

    Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on incretin hormones. / Olthof, MR; van Dijk, AE; Deacon, Carolyn F.; Heine, RJ; van Dam, RM .

    In: Nutrition & Metabolism, Vol. 8, 2011, p. Artikel 10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  95. Published

    Dipeptidyl peptidase-4 inhibition increases portal concentrations of intact glucagon-like peptide-1 (GLP-1) to a greater extent than peripheral concentrations in anaesthetised pigs. / Hjøllund, K R; Deacon, C F; Holst, Jens Juul.

    In: Diabetologia, Vol. 54, No. 8, 2011, p. 2206-8.

    Research output: Contribution to journalLetterResearchpeer-review

  96. Published

    Effects of saxagliptin on β-cell stimulation and insulin secretion in patients with type 2 diabetes. / Henry, R R; Smith, Susanne; Schwartz, Saul; Mudaliar, S R; Deacon, C F; Holst, Jens Juul; Duan, R Y; Chen, R S; List, J F.

    In: Diabetes, Obesity and Metabolism, Vol. 13, No. 9, 2011, p. 850-858.

    Research output: Contribution to journalJournal articleResearchpeer-review

  97. Published

    GIP does not potentiate the antidiabetic effects of GLP-1 in hyperglycemic patients with type 2 diabetes. / Mentis, Nikolaos; Vardarli, Irfan; Köthe, Lars D; Holst, Jens Juul; Deacon, Carolyn F; Theodorakis, Michael; Meier, Juris J; Nauck, Michael A.

    In: Diabetes, Vol. 60, No. 4, 2011, p. 1270-1276.

    Research output: Contribution to journalJournal articleResearchpeer-review

  98. Published

    Incretin-based therapies– review of the physiology, pharmacology and emerging clinical experience. / Martin, JH; Deacon, Carolyn F.; Gorrell, MD; Prins, JB.

    In: Internal Medicine Journal (Online), Vol. 41, 2011, p. 299-307.

    Research output: Contribution to journalReviewResearchpeer-review

  99. Published

    Inhibition of DPP-4 with vildagliptin improved insulin secretion in response to oral as well as "isoglycemic" intravenous glucose without numerically changing the incretin effect in patients with type 2 diabetes. / Vardarli, Irfan; Nauck, Michael A; Köthe, Lars D; Deacon, Carolyn F; Holst, Jens Juul; Schweizer, Anja; Foley, James E.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 96, No. 4, 2011, p. 945-954.

    Research output: Contribution to journalJournal articleResearchpeer-review

  100. Published

    Physiology of incretins in health and disease. / Deacon, Carolyn F.; Ahren, Bo.

    In: Review of Diabetic Studies, Vol. 8, No. 3, 2011, p. 293-306.

    Research output: Contribution to journalReviewResearchpeer-review

  101. Published

    Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes : what is up, what is down? / Nauck, M A; Vardarli, I; Deacon, C F; Holst, Jens Juul; Meier, Joachim.

    In: Diabetologia, Vol. 54, No. 1, 2011, p. 10-18.

    Research output: Contribution to journalJournal articleResearchpeer-review

  102. 2010
  103. Published

    Dipeptidyl peptidase-4 inhibitors administered in combination with metformin result in an additive increase in the plasma concentration of active GLP-1. / Migoya, E M; Bergeron, R; Miller, J L; Snyder, R N K; Tanen, M; Hilliard, D; Weiss, B; Larson, P; Gutierrez, M; Jiang, G; Liu, F.; Pryor, K A; Yao, J; Zhu, L; Holst, Jens Juul; Deacon, C; Herman, G; Thornberry, N; Amatruda, J; Williams-Herman, D; Wagner, J A; SinhaRoy, R.

    In: Clinical Pharmacology and Therapeutics, Vol. 88, No. 6, 01.12.2010, p. 801-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  104. Published

    Impact of exogenous hyperglucagonemia on postprandial concentrations of gastric inhibitory polypeptide and glucagon-like peptide-1 in humans. / Meier, Juris J; Ritter, Peter R; Jacob, Alexandra; Menge, Bjoern A; Deacon, Carolyn F; Schmidt, Wolfgang E; Nauck, Michael A; Holst, Jens J.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 95, No. 8, 01.08.2010, p. 4061-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  105. Published

    The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action. / Hare, Kristine J; Vilsbøll, Tina; Asmar, Meena; Deacon, Carolyn F; Knop, Filip K; Holst, Jens Juul.

    In: Diabetes, Vol. 59, No. 7, 01.07.2010, p. 1765-70.

    Research output: Contribution to journalJournal articleResearchpeer-review

  106. Published

    Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese : Comparison of type 2 diabetes patients and healthy controls. / Yabe, Daisuke; Kuroe, Akira; Lee, Soushou; Watanabe, Koin; Hyo, Takanori; Hishizawa, Masahiro; Kurose, Takeshi; Deacon, Carolyn F; Holst, Jens Juul; Hirano, Tsutomu; Inagaki, Nobuya; Seino, Yutaka.

    In: Journal of Diabetes Investigation, Vol. 1, No. 1-2, 22.04.2010, p. 56-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  107. Published

    Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose and non-glucose induced insulin secretion in patients with type 2 diabetes mellitus. / Aaboe, K; Knop, F K; Vilsbøll, T; Deacon, C F; Holst, Jens Juul; Madsbad, S; Krarup, Troels Magelund.

    In: Diabetes, Obesity and Metabolism, Vol. 12, No. 4, 01.04.2010, p. 323-33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  108. Published

    Reversible hyperinsulinemic hypoglycemia after gastric bypass: a consequence of altered nutrient delivery. / McLaughlin, Tracey; Peck, Marcia; Holst, Jens; Deacon, Carolyn.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 95, No. 4, 04.2010, p. 1851-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  109. Published

    Linagliptin, a xanthine-based dipeptidyl peptidase-4 inhibitor with an unusual profile for the treatment of type 2 diabetes. / Deacon, Carolyn F; Holst, Jens Juul.

    In: Expert Opinion on Investigational Drugs, Vol. 19, No. 1, 01.2010, p. 133-40.

    Research output: Contribution to journalJournal articleResearchpeer-review

  110. Published

    Little enhancement of meal-induced GLP-1 secretion in Japanese: Comparison of type 2 diabetes and healthy controls. / Yabe, D; Kuroe, A; Lee, S; Watanabe, K; Hyo, T; Hishizawa, M; Kurose, T; Deacon, Carolyn F.; Holst, Jens Juul; Hirano, T; Inagaki, N; Seino, Y.

    In: Journal of Diabetes Investigation, Vol. 1, No. 1/2, 01.2010, p. 56-59.

    Research output: Contribution to journalJournal articleResearchpeer-review

  111. Published

    Incretin hormone secretion over the day. / Ahren, B; Carr, RD; Deacon, Carolyn F.

    In: Vitamins and Hormones, Vol. 84, 2010, p. 203-220.

    Research output: Contribution to journalReviewResearchpeer-review

  112. Published

    Linagliptin, a xanthine-based dipeptidyl peptidase-4 inhibitor with an unusual profile for the treatment of type 2 diabetes. / Deacon, Carolyn F.; Holst, Jens Juul.

    In: Expert Opinion on Investigational Drugs, Vol. 19, No. 1, 2010, p. 133-140.

    Research output: Contribution to journalReviewResearchpeer-review

  113. Published

    Pancreatic beta-cell responses to GLP-1 after near-normalization of blood glucose in patients with type 2 diabetes. / Asmar, Meena; Højberg, Patricia V; Deacon, Carolyn F; Hare, Kristine; Holst, Jens Juul; Madsbad, Sten.

    In: Regulatory Peptides, Vol. 160, No. 1-3, 2010, p. 175-80.

    Research output: Contribution to journalJournal articleResearchpeer-review

  114. Published

    Pancreatic ß-cell responses to GLP-1 after near-normalization of blood glucose in patients with type 2 diabetes. / Asmar, Meena; Højberg, Patricia; Deacon, Carolyn F.; Hare, Kristine; Holst, Jens Juul; Madsbad, Sten.

    In: Regulatory Peptides, Vol. 160, No. 1-3, 2010, p. 175-180.

    Research output: Contribution to journalJournal articleResearchpeer-review

  115. Published

    Secretion and dipeptidyl peptidase-4-mediated metabolism of incretin hormones after a mixed meal or glucose ingestion in obese compared to lean, nondiabetic men. / Carr, Richard D; Larsen, Marianne O; Jelic, Katarina; Lindgren, Ola; Vikman, Jenny; Holst, Jens J; Deacon, Carolyn F; Ahrén, Bo.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 95, No. 2, 2010, p. 872-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  116. Published

    The effect of DPP-4 inhibition with sitagliptin on incretin secretion and on fasting and postprandial glucose turnover in subjects with impaired fasting glucose. / Bock, Gerlies; Man, Chiara Dalla; Micheletto, Francesco; Basu, Rita; Rn, Paula D Giesler; Laugen, Jeanette; Deacon, Carolyn F; Holst, Jens J; Toffolo, Gianna; Cobelli, Claudio; Rizza, Robert A; Vella, Adrian.

    In: Clinical Endocrinology, Vol. 73, 2010, p. 189-196.

    Research output: Contribution to journalJournal articleResearchpeer-review

  117. Published
  118. 2009
  119. Published

    DPP-4 inhibition – advances in our understanding of diabetes management. / Deacon, Carolyn F.; Holst, Jens Juul.

    In: European Endocrinology, Vol. 4, 2009, p. 47-49.

    Research output: Contribution to journalReviewResearch

  120. Published

    Differential islet and incretin hormone responses in morning versus afternoon after standardized meal in healthy men. / Lindgren, Ola; Mari, Andrea; Deacon, Carolyn F; Carr, Richard D; Winzell, Maria Sörhede; Vikman, Jenny; Ahrén, Bo.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 94, No. 8, 2009, p. 2887-92.

    Research output: Contribution to journalJournal articleResearchpeer-review

  121. Published

    Hyperglycemia acutely lowers the postprandial excursions of glucagon-like Peptide-1 and gastric inhibitory polypeptide in humans. / Vollmer, Kirsten; Gardiwal, Husai; Menge, Bjoern A; Goetze, Oliver; Deacon, Carolyn F; Schmidt, Wolfgang E; Holst, Jens Juul; Meier, Juris J.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 94, No. 4, 2009, p. 1379-85.

    Research output: Contribution to journalJournal articleResearchpeer-review

  122. Published

    Immunoassays for the incretin hormones GIP and GLP-1. / Deacon, Carolyn F; Holst, Jens J.

    In: Best Practice & Research: Clinical Endocrinology & Metabolism, Vol. 23, No. 4, 2009, p. 425-32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  123. Published

    Incretin hormones and diabetes mellitus. / Vilsbøll, Tina; Knop, Filip Krag; Deacon, Carolyn F.; Holst, Jens Juul.

    Therapeutic Strategies in Diabetes. ed. / Coen D.A. Stehouwer; Nicolaas Schaper. Oxford : Clinical Publishing, 2009. p. 99-114.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  124. Published

    Inhibition of neutral endopeptidase 24.11 does not potentiate the improvement in glycemic control obtained with dipeptidyl peptidase-4 inhibition in diabetic Goto-Kakizaki rats. / Simonsen, L; Pilgaard, S; Carr, R D; Kanstrup, A B; Holst, Jens Juul; Deacon, C F.

    In: Hormone and Metabolic Research, Vol. 41, No. 11, 2009, p. 851-3.

    Research output: Contribution to journalJournal articleResearchpeer-review

  125. Published

    KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide (GIP) in patients with type 2 diabetes. / Aaboe, Kasper; Knop, Filip Krag; Vilsbøll, Tina; Vølund, A; Simonsen, U; Deacon, Carolyn F.; Madsbad, Sten; Holst, Jens Juul; Krarup, Thure.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 94, No. 2, 2009, p. 603-608.

    Research output: Contribution to journalJournal articleResearchpeer-review

  126. Published

    Long-term exendin-4 treatment delays natural deterioration of glycaemic control in diabetic Goto-Kakizaki rats. / Simonsen, L; Pilgaard, S; Orskov, C; Hartmann, B; Holst, Jens Juul; Deacon, C F.

    In: Diabetes, Obesity and Metabolism, Vol. 11, No. 9, 2009, p. 884-90.

    Research output: Contribution to journalJournal articleResearchpeer-review

  127. Published

    Potential of liraglutide in the treatment of patients with type 2 diabetes. / Deacon, Carolyn F.

    In: Vascular Health and Risk Management (Online), Vol. 5, No. 1, 2009, p. 199-211.

    Research output: Contribution to journalJournal articleResearchpeer-review

  128. Published

    Preserved inhibitory potency of GLP-1 on glucagon secretion in type 2 diabetes mellitus. / Hare, Kristine J; Knop, Filip K; Asmar, Meena; Madsbad, Sten; Deacon, Carolyn F; Holst, Jens J; Vilsbøll, Tina.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 94, No. 12, 2009, p. 4679-87.

    Research output: Contribution to journalJournal articleResearchpeer-review

  129. Published

    Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes. / Deacon, Carolyn F; Holst, Jens J.

    In: Advances in Therapy, Vol. 26, No. 5, 2009, p. 488-99.

    Research output: Contribution to journalJournal articleResearchpeer-review

  130. Published
  131. 2008
  132. Published

    Effect of vildagliptin on glucagon concentration during meals in patients with type 1 diabetes. / Foley, J E; Ligueros-Saylan, M; He, Y-L; Holst, Jens Juul; Deacon, C F; Dunning, B E; Leone-Jones, A; Yu, T; Kelley, D E.

    In: Hormone and Metabolic Research. Supplement, Vol. 40, No. 10, 10.2008, p. 727-30.

    Research output: Contribution to journalJournal articleResearchpeer-review

  133. Published

    Glucagon-like peptide receptor agonists and dipeptidyl peptidase-4 inhibitors in the treatment of diabetes : a review of clinical trials. / Madsbad, Sten; Krarup, Thure; Deacon, Carolyn F; Holst, Jens Juul.

    In: Current Opinion in Clinical Nutrition and Metabolic Care, Vol. 11, No. 4, 07.2008, p. 491-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  134. Published

    Alogliptin, a potent and selective dipeptidyl peptidase-IV inhibitor for the treatment of type 2 diabetes. / Deacon, Carolyn F.

    In: Current Opinion in Investigational Drugs, Vol. 9, No. 4, 2008, p. 402-13.

    Research output: Contribution to journalJournal articleResearchpeer-review

  135. Published

    DPP-4 inhibitor therapy: new directions in the treatment of type 2 diabetes. / Deacon, Carolyn F; Carr, Richard D; Holst, Jens Juul.

    In: Frontiers in Bioscience, Vol. 13, 2008, p. 1780-94.

    Research output: Contribution to journalJournal articleResearchpeer-review

  136. Published

    Effect of Vildagliptin on Glucagon Concentration During Meals in Patients with Type 1 Diabetes. / Foley, J.E.; Ligueros-Saylan, M.; He, Y.L.; Holst, Jens Juul; Deacon, Carolyn F.; Dunning, B.E.; Leone-Jones, A.; Yu, T.; Kelley, D.E.

    In: Hormone and Metabolic Research, Vol. 40, No. 10, 2008, p. 727-730.

    Research output: Contribution to journalJournal articleResearchpeer-review

  137. Published

    Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia in subjects with impaired glucose tolerance. / Rosenstock, Julio; Foley, James E; Rendell, Marc; Landin-Olsson, Mona; Holst, Jens J; Deacon, Carolyn F; Rochotte, Erika; Baron, Michelle A.

    In: Diabetes Care, Vol. 31, No. 1, 2008, p. 30-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  138. Published

    Glucagon-like peptide receptor agonists and dipeptidyl peptidase-4 inhibitors in the treatment of diabetes: a review of clinical trials. / Madsbad, Sten; Krarup, Thure; Deacon, Carolyn F; Holst, Jens Juul; Madsbad, Sten; Krarup, Thure; Deacon, Carolyn F; Holst, Jens J.

    In: Current Opinion in Clinical Nutrition and Metabolic Care, Vol. 11, No. 4, 2008, p. 491-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  139. Published

    Glucagon-like peptide-1, glucose homeostasis and diabetes. / Holst, Jens Juul; Deacon, Carolyn F; Vilsbøll, Tina; Krarup, Thure; Madsbad, Sten.

    In: Trends in Molecular Medicine, Vol. 14, No. 4, 2008, p. 161-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  140. Published

    Incretin and islet hormonal responses to fat and protein ingestion in healthy men. / Carr, Richard D; Larsen, Marianne O; Winzell, Maria Sörhede; Jelic, Katarina; Lindgren, Ola; Deacon, Carolyn F; Ahrén, Bo.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 295, No. 4, 2008, p. E779-84.

    Research output: Contribution to journalJournal articleResearchpeer-review

  141. Published

    KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes. / Aaboe, Kasper; Knop, Filip Krag; Vilsboll, Tina; Vølund, Aage; Simonsen, Ulf; Deacon, Carolyn F.; Madsbad, Sten; Holst, Jens Juul; Krarup, Thure.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 94, No. 2, 2008, p. 603-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  142. Published

    Measurements Inhibition of DPP-4 evokes pancreatic and extra-pancreatic mechanisms that improve glucose homeostasis in type 2 diabetes mellitus. / Azuma, K; Radikova, Z; Mancino, J; Toledo, FGS; Thomas, E; Kangani, C; Dalla Man, C; Cobelli, C; Holst, Jens Juul; Deacon, Carolyn F.; He, Y; Ligueros-Saylan, M; Serra, D; Kelley, DE.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 93, 2008, p. 459-463.

    Research output: Contribution to journalJournal articleResearchpeer-review

  143. Published

    Overnight hypoxic exposure and glucagon-like peptide-1 and leptin levels in humans. / Snyder, Eric M; Carr, Richard D; Deacon, Carolyn F; Johnson, Bruce D.

    In: Applied Physiology, Nutrition and Metabolism, Vol. 33, No. 5, 2008, p. 929-35.

    Research output: Contribution to journalJournal articleResearchpeer-review

  144. Published

    The effect of dipeptidyl peptidase 4 inhibition on gastric volume, satiation and enteroendocrine secretion in Type 2 diabetes: a double blind, placebo-controlled crossover study. / Vella, Adrian; Bock, Gerlies; Giesler, Paula D; Burton, Duane B; Serra, Denise B; Saylan, Monica Ligueros; Deacon, Carolyn F; Foley, James E; Rizza, Robert A; Camilleri, Michael.

    In: Clinical Endocrinology, 2008.

    Research output: Contribution to journalJournal articleResearchpeer-review

  145. Published

    The incretin system and its role in type 2 diabetes mellitus. / Holst, Jens Juul; Vilsbøll, Tina; Deacon, Carolyn F.

    In: Molecular and Cellular Endocrinology, Vol. 297, No. 1-2, 2008, p. 127-136.

    Research output: Contribution to journalJournal articleResearchpeer-review

  146. 2007
  147. Published

    Dipeptidyl peptidase 4 inhibition with sitagliptin: a new therapy for type 2 diabetes. / Deacon, Carolyn F.

    In: Expert Opinion on Investigational Drugs, Vol. 16, No. 4, 2007, p. 533-45.

    Research output: Contribution to journalJournal articleResearchpeer-review

  148. Published

    Exendin-4, but not dipeptidyl peptidase IV inhibition, increases small intestinal mass in GK rats. / Simonsen, Lotte; Pilgaard, Sofie; Orskov, Cathrine; Rosenkilde, Mette M; Hartmann, Bolette; Holst, Jens J; Deacon, Carolyn F.

    In: American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol. 293, No. 1, 2007, p. G288-95.

    Research output: Contribution to journalJournal articleResearchpeer-review

  149. Published

    Incretin-based treatment of type 2 diabetes: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors. / Deacon, Carolyn F.

    In: Diabetes, Obesity and Metabolism, Vol. 9 Suppl 1, 2007, p. 23-31.

    Research output: Contribution to journalJournal articleResearchpeer-review

  150. Published

    Measurements of islet function and glucose metabolism with the dipeptidyl peptidase 4 inhibitor vildagliptin in patients with type 2 diabetes. / Azuma, Koichiro; Rádiková, Zofia; Mancino, Juliet; Toledo, Frederico G S; Thomas, Ernestine; Kangani, Cyrous; Dalla Man, Chiara; Cobelli, Claudio; Holst, Jens J; Deacon, Carolyn F; He, Yanling; Ligueros-Saylan, Monica; Serra, Denise; Foley, James E; Kelley, David E.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 93, No. 2, 2007, p. 459-464.

    Research output: Contribution to journalJournal articleResearchpeer-review

  151. Published

    New horizons in diabetes therapy. / Holst, J.J.; Deacon, C.F.

    In: Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, Vol. 7, No. 1, 2007, p. 49-55.

    Research output: Contribution to journalJournal articleResearchpeer-review

  152. Published

    Pharmacodynamics of vildagliptin in patients with type 2 diabetes during OGTT. / He, Yan-Ling; Wang, Yibin; Bullock, Julie M; Deacon, Carolyn F; Holst, Jens Juul; Dunning, Beth E; Ligueros-Saylan, Monica; Foley, James E.

    In: Journal of Clinical Pharmacology, Vol. 47, No. 5, 2007, p. 633-41.

    Research output: Contribution to journalJournal articleResearchpeer-review

  153. Published

    Pharmacokinetics and pharmacodynamics of vildagliptin in patients with type 2 diabetes mellitus. / He, Yan-Ling; Serra, Denise; Wang, Yibin; Campestrini, Joelle; Riviere, Gilles-Jacques; Deacon, Carolyn F; Holst, Jens J; Schwartz, Sherwyn; Nielsen, Jace C; Ligueros-Saylan, Monica.

    In: Clinical Pharmacokinetics, Vol. 46, No. 7, 2007, p. 577-88.

    Research output: Contribution to journalJournal articleResearchpeer-review

  154. Published

    Suppression of glucagon secretion is lower after oral glucose administration than during intravenous glucose administration in human subjects. / Meier, J.J.; Deacon, C.F.; Schmidt, Wolfgang E.; Holst, J.J.; Nauck, M.A.

    In: Diabetologia, Vol. 50, No. 4, 2007, p. 806-813.

    Research output: Contribution to journalJournal articleResearchpeer-review

  155. Published

    The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients. / Balas, Bogdan; Baig, Muhammad R; Watson, Catherine; Dunning, Beth E; Ligueros-Saylan, Monica; Wang, Yibin; He, Yan-Ling; Darland, Celia; Holst, Jens J; Deacon, Carolyn F; Cusi, Kenneth; Mari, Andrea; Foley, James E; DeFronzo, Ralph A.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 92, No. 4, 2007, p. 1249-55.

    Research output: Contribution to journalJournal articleResearchpeer-review

  156. Published

    The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose. / Utzschneider, Kristina M; Tong, Jenny; Montgomery, Brenda; Udayasankar, Jayalakshmi; Gerchman, Fernando; Marcovina, Santica M; Watson, Catherine E; Ligueros-Saylan, Monica A; Foley, James E; Holst, Jens J; Deacon, Carolyn F; Kahn, Steven E.

    In: Diabetes Care, Vol. 31, No. 1, 2007, p. 108-113.

    Research output: Contribution to journalJournal articleResearchpeer-review

  157. 2006
  158. Published

    Plasma dipeptidyl peptidase-IV activity in patients with type-2 diabetes mellitus correlates positively with HbAlc levels, but is not acutely affected by food intake. / Ryskjaer, Jakob; Deacon, Carolyn F; Carr, Richard D; Krarup, Thure; Madsbad, Sten; Holst, Jens; Vilsbøll, Tina; Ryskjaer, Jakob; Deacon, Carolyn F.; Carr, Richard D; Krarup, Thure; Madsbad, Sten; Holst, Jens Juul; Vilsbøll, Tina.

    In: European Journal of Endocrinology, Vol. 155, No. 3, 01.09.2006, p. 485-93.

    Research output: Contribution to journalJournal articleResearchpeer-review

  159. Published

    Exendin-4, but not glucagon-like peptide-1, is cleared exclusively by glomerular filtration in anaesthetised pigs. / Simonsen, L; Holst, Jens Juul; Deacon, C F.

    In: Diabetologia, Vol. 49, No. 4, 04.2006, p. 706-12.

    Research output: Contribution to journalJournal articleResearchpeer-review

  160. Published

    The metabolite generated by dipeptidyl-peptidase 4 metabolism of glucagon-like peptide-1 has no influence on plasma glucose levels in patients with type 2 diabetes. / Zander, M; Madsbad, S; Deacon, C F; Holst, Jens Juul.

    In: Diabetologia, Vol. 49, No. 2, 02.2006, p. 369-74.

    Research output: Contribution to journalJournal articleResearchpeer-review

  161. Published

    Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes. / Herman, Gary A; Bergman, Arthur; Stevens, Catherine; Kotey, Paul; Yi, Bingming; Zhao, Peng; Dietrich, Bruno; Golor, George; Schrodter, Andreas; Keymeulen, Bart; Lasseter, Kenneth C; Kipnes, Mark S; Snyder, Karen; Hilliard, Deborah; Tanen, Michael; Cilissen, Caroline; De Smet, Marina; de Lepeleire, Inge; Van Dyck, Kristien; Wang, Amy Q; Zeng, Wei; Davies, Michael J; Tanaka, Wesley; Holst, Jens J; Deacon, Carolyn F; Gottesdiener, Keith M; Wagner, John A.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 91, No. 11, 2006, p. 4612-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  162. Published

    Exendin-4, but not glucagon-like peptide-1, is cleared exclusively by glomerular filtration in anaesthetised pigs. / Simonsen, L.; Holst, J.J.; Deacon, C.F.

    In: Diabetologia, Vol. 49, No. 4, 2006, p. 706-712.

    Research output: Contribution to journalJournal articleResearchpeer-review

  163. Published

    GIP-(3-42) does not antagonize insulinotropic effects of GIP at physiological concentrations. / Deacon, Carolyn F; Plamboeck, Astrid; Rosenkilde, Mette M; de Heer, Jocelyn; Holst, Jens J.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 291, No. 3, 2006, p. E468-75.

    Research output: Contribution to journalJournal articleResearchpeer-review

  164. Published

    Glucose-induced incretin hormone release and inactivation are differently modulated by oral fat and protein in mice. / Gunnarsson, P Thomas; Winzell, Maria Sörhede; Deacon, Carolyn F; Larsen, Marianne O; Jelic, Katarina; Carr, Richard D; Ahrén, Bo.

    In: Endocrinology, Vol. 147, No. 7, 2006, p. 3173-80.

    Research output: Contribution to journalJournal articleResearchpeer-review

  165. Published

    Glucose-stimulated prehepatic insulin secretion is associated with circulating alanine, triglyceride, glucagon, lactate and TNF-alpha in patients with HIV-lipodystrophy. / Haugaard, S B; Andersen, O; Pedersen, S B; Dela, F; Deacon, C F; Holst, Jens Juul; Iversen, J; Madsbad, S.

    In: HIV Medicine, Vol. 7, No. 3, 2006, p. 163-72.

    Research output: Contribution to journalJournal articleResearchpeer-review

  166. Published

    Influence of gastric inhibitory polypeptide on pentagastrin-stimulated gastric acid secretion in patients with type 2 diabetes and healthy controls. / Meier, Juris J; Nauck, Michael A; Kask, Bartholomaeus; Holst, Jens J; Deacon, Carolyn F; Schmidt, Wolfgang E; Gallwitz, Baptist.

    In: World Journal of Gastroenterology, Vol. 12, No. 12, 2006, p. 1874-80.

    Research output: Contribution to journalJournal articleResearchpeer-review

  167. Published

    Metabolism of glucagon-like peptide-2 in pigs: role of dipeptidyl peptidase IV. / Hansen, Lene; Hare, Kristine J; Hartmann, Bolette; Deacon, Carolyn F; Ugleholdt, Randi K; Plamboeck, Astrid; Holst, Jens J.

    In: Regulatory Peptides, Vol. 138, No. 2-3, 2006, p. 126-32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  168. Published

    Role of GLP-1 analogues and DDP-IV inhibitors in the treatment of type 2 diabetes. / Holst, J.J.; Deacon, C.F.

    In: Avances en Diabetologia, Vol. 22, No. 2, 2006, p. 115-125.

    Research output: Contribution to journalJournal articleResearchpeer-review

  169. Published

    The elimination rates of intact GIP as well as its primary metabolite, GIP 3-42, are similar in type 2 diabetic patients and healthy subjects. / Vilsbøll, Tina; Agersø, Henrik; Lauritsen, Torsten; Deacon, Carolyn F; Aaboe, Kasper; Madsbad, Sten; Krarup, Thure; Holst, Jens Juul.

    In: Regulatory Peptides, Vol. 137, No. 3, 2006, p. 168-72.

    Research output: Contribution to journalJournal articleResearchpeer-review

  170. Published

    The glucagon-like peptide-1 metabolite GLP-1-(9-36) amide reduces postprandial glycemia independently of gastric emptying and insulin secretion in humans. / Meier, Juris J; Gethmann, Arnica; Nauck, Michael A; Götze, Oliver; Schmitz, Frank; Deacon, Carolyn F; Gallwitz, Baptist; Schmidt, Wolfgang E; Holst, Jens J.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 290, No. 6, 2006, p. E1118-23.

    Research output: Contribution to journalJournal articleResearchpeer-review

  171. Published

    The metabolite generated by dipeptidyl-peptidase 4 metabolism of glucagon-like peptide-1 has no influence on plasma glucose levels in patients with type 2 diabetes. / Zander, M.; Madsbad, S.; Deacon, C.F.; Holst, J.J.

    In: Diabetologia, Vol. 49, No. 2, 2006, p. 369-374.

    Research output: Contribution to journalJournal articleResearchpeer-review

  172. 2005
  173. Published

    Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both mediators of the degradation of glucagon-like peptide 1 in the anaesthetised pig. / Plamboeck, A; Holst, Jens Juul; Carr, R D; Deacon, C F.

    In: Diabetologia, Vol. 48, No. 9, 09.2005, p. 1882-90.

    Research output: Contribution to journalJournal articleResearchpeer-review

  174. Published

    Secretion of incretin hormones and the insulinotropic effect of gastric inhibitory polypeptide in women with a history of gestational diabetes. / Meier, J J; Gallwitz, B; Askenas, M; Vollmer, K; Deacon, C F; Holst, Jens Juul; Schmidt, W E; Nauck, M A.

    In: Diabetologia, Vol. 48, No. 9, 09.2005, p. 1872-81.

    Research output: Contribution to journalJournal articleResearchpeer-review

  175. Published

    Vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed beta-cell function in patients with type 2 diabetes. / Mari, A; Sallas, W M; He, Y L; Watson, C; Ligueros-Saylan, M; Dunning, B E; Deacon, C F; Holst, Jens Juul; Foley, J E.

    In: The Journal of clinical endocrinology and metabolism, Vol. 90, No. 8, 08.2005, p. 4888-94.

    Research output: Contribution to journalJournal articleResearchpeer-review

  176. Published

    Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors. / Holst, Jens Juul; Deacon, C F.

    In: Diabetologia, Vol. 48, No. 4, 04.2005, p. 612-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  177. Published

    Enhanced glucagon-like peptide-1 (GLP-1) response to oral glucose in glucose-intolerant HIV-infected patients on antiretroviral therapy. / Andersen, O; Haugaard, S B; Holst, Jens Juul; Deacon, C F; Iversen, J; Andersen, U B; Nielsen, J O; Madsbad, S.

    In: HIV Medicine, Vol. 6, No. 2, 03.2005, p. 91-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  178. Published

    Dipeptidyl peptidase IV inhibitors: a promising new therapeutic approach for the management of type 2 diabetes. / Deacon, Carolyn F; Holst, Jens J.

    In: International Journal of Biochemistry & Cell Biology, Vol. 38, No. 5-6, 2005, p. 831-44.

    Research output: Contribution to journalJournal articleResearchpeer-review

  179. Published

    Enhanced glucagon-like peptide- 1 (GLP-1) response to oral glucose in glucose intolerant HIV-infected patients on antiretroviral therapy. / Andersen, O.; Haugaard, S.B.; Holst, Jens Juul; Deacon, Carolyn F.; Iversen, J.; Andersen, U.B.; Nielsen, J.O.; Madsbad, S.

    In: HIV Medicine, Vol. 6, 2005, p. 91-98.

    Research output: Contribution to journalJournal articleResearchpeer-review

  180. Published

    For debate: Are antidiabetic actions of DPP-IV inhibitors mediated by glucagon-like peptide- 1? / Holst, Jens Juul; Deacon, Carolyn F.

    In: Diabetologia, No. 48, 2005, p. 612-615.

    Research output: Contribution to journalJournal articleResearchpeer-review

  181. Published

    Glucagon-like peptide-1 mediates the therapeutic actions of Dpp-IV inhibitors. / Holst, Jens Juul; Deacon, Carolyn F.

    In: Diabetologia, No. 48, 2005, p. 612-615.

    Research output: Contribution to journalJournal articleResearchpeer-review

  182. Published

    Insulinotropic effect of gastric inhibitory polypeptide (GIP) in women with a history of gestational diabetes. / Meier, J.J.; Gallwitz, B.; Askenas, M.; Vollmer, K.; Deacon, C.F.; Holst, J.J.; Schmidt, W.E.; Nauck, M.A.

    In: Diabetologia, No. 48, 2005, p. 1872-1881.

    Research output: Contribution to journalJournal articleResearch

  183. Published

    MK-431 (Merck). / Deacon, Carolyn F.

    In: Current Opinion in Investigational Drugs, Vol. 6, No. 4, 2005, p. 419-26.

    Research output: Contribution to journalJournal articleResearchpeer-review

  184. Published

    Neutral Endopeptidase 24.11 and dipeptidyl peptidase IV are both physiological mediators of the degradation of glucagon-like peptide-1 in the anaesthetized pig. / Plamboeck, A.; Holst, J.J.; Carr, R.D.; Deacon, C.F.

    In: Diabetologia, No. 48, 2005, p. 1882-1890.

    Research output: Contribution to journalJournal articleResearchpeer-review

  185. Published

    Normal secretion and action of the gut incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in young men with low birth weight. / Schou, Jakob Hagen; Pilgaard, Kasper; Vilsbøll, Tina; Jensen, Christine B; Deacon, Carolyn F; Holst, Jens Juul; Vølund, Aage; Madsbad, Sten; Vaag, Allan A.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 90, No. 8, 2005, p. 4912-19.

    Research output: Contribution to journalJournal articleResearchpeer-review

  186. Published

    Sensory nerve desensitization by resiniferatoxin improves glucose tolerance and increases insulin secretion in Zucker Diabetic Fatty rats and is associated with reduced plasma activity of dipeptidyl peptidase IV. / Gram, Dorte X; Hansen, Anker J; Deacon, Carolyn F; Brand, Christian L; Ribel, Ulla; Wilken, Michael; Carr, Richard D; Svendsen, Ove; Ahrén, Bo.

    In: European Journal of Pharmacology, Vol. 509, No. 2-3, 2005, p. 211-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  187. Published

    The incretin enhancer vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed -cell function in patients with type 2 diabetes. / Mari, A.; Sallas, W.M.; He, Y.L.; Watson, C.; Ligueros-Saylan, M.; Dunning, B.E.; Deacon, Carolyn F.; Holst, Jens Juul; Foley, J.E.

    In: Journal of Clinical Endocrinology and Metabolism, No. 90, 2005, p. 4888-4894.

    Research output: Contribution to journalJournal articleResearch

  188. Published

    Vildagliptin, a dipeptidyl peptidase-IV inhibitor improves model-assessed beta-cell function in patients with type 2 diabetes. / Mari, A.; Sallas, W.M.; He, Y.L.; Watson, C.; Ligueros-Saylan, M.; Duning, B.E.; Deacon, Carolyn F.; Holst, Jens Juul; Foley, J.E.

    In: J. Clin. Endocrinol. Metab., No. 90, 2005, p. 4888-4894.

    Research output: Contribution to journalJournal articleResearch

  189. Published

    What do we know about the secretion and degradation of incretin hormones? / Deacon, Carolyn F.

    In: Regulatory Peptides, Vol. 128, No. 2, 2005, p. 117-24.

    Research output: Contribution to journalJournal articleResearchpeer-review

  190. 2004
  191. Published

    Circulation and degradation of GIP and GLP-1. / Deacon, Carolyn F.

    In: Hormone and Metabolic Research, No. 36, 2004, p. 761-765.

    Research output: Contribution to journalJournal articleResearchpeer-review

  192. Published

    Glucagon-like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus. / Holst, Jens Juul; Deacon, Carolyn F.

    In: Current Opinion in Pharmacology, Vol. 4, No. 6, 2004, p. 589-96.

    Research output: Contribution to journalJournal articleResearchpeer-review

  193. Published

    Inhibitors of dipeptidyl peptidase IV: a novel approach for the prevention and treatment of Type 2 diabetes? / Deacon, Carolyn F; Ahrén, Bo; Holst, Jens J.

    In: Expert Opinion on Investigational Drugs, Vol. 13, No. 9, 2004, p. 1091-102.

    Research output: Contribution to journalJournal articleResearchpeer-review

  194. Published

    Neutral endopeptidase 24.11 is important for the degradation of both endogenous and exogenous glucagon in anesthetized pigs. / Trebbien, Ramona; Klarskov, Letty; Olesen, Mette; Holst, Jens J; Carr, Richard D; Deacon, Carolyn F.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 287, No. 3, 2004, p. E431-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  195. Published

    Secretion of incretin hormones (GIP and GLP-1) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetes. / Nauck, Michael A; El-Ouaghlidi, Andrea; Gabrys, Bartholomäus; Hücking, Katrin; Holst, Jens J; Deacon, Carolyn F; Gallwitz, Baptist; Schmidt, Wolfgang E; Meier, Juris J.

    In: Regulatory Peptides, Vol. 122, No. 3, 2004, p. 209-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  196. Published

    Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects. / Meier, Juris J; Nauck, Michael A; Kranz, Daniel; Holst, Jens J; Deacon, Carolyn F; Gaeckler, Dirk; Schmidt, Wolfgang E; Gallwitz, Baptist.

    In: Diabetes, Vol. 53, No. 3, 2004, p. 654-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  197. Published

    Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects. / Meier, Juris J; Gallwitz, Baptist; Kask, Bartholomaeus; Deacon, Carolyn F; Holst, Jens J; Schmidt, Wolfgang E; Nauck, Michael A.

    In: Diabetes, Vol. 53 Suppl 3, 2004, p. S220-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  198. Published

    The major glucagon-like peptide-1 metabolite, GLP-1-(9-36)-amide, does not affect glucose or insulin levels in mice. / Rolin, Bidda; Deacon, Carolyn F; Carr, Richard D; Ahrén, Bo.

    In: European Journal of Pharmacology, Vol. 494, No. 2-3, 2004, p. 283-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  199. Published

    Therapeutic strategies based on glucagon-like peptide 1. / Deacon, Carolyn F.

    In: Diabetes, Vol. 53, No. 9, 2004, p. 2181-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  200. 2003
  201. Published

    Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia. / Meier, J J; Gallwitz, B; Siepmann, N; Holst, Jens Juul; Deacon, C F; Schmidt, W E; Nauck, M A.

    In: Diabetologia, Vol. 46, No. 6, 06.2003, p. 798-801.

    Research output: Contribution to journalJournal articleResearchpeer-review

  202. Published

    Differential regional metabolism of glucagon in anesthetized pigs. / Deacon, Carolyn F; Kelstrup, Mette; Trebbien, Ramona; Klarskov, Letty; Olesen, Mette; Holst, Jens J.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 285, No. 3, 2003, p. E552-60.

    Research output: Contribution to journalJournal articleResearchpeer-review

  203. Published

    GLP-1 derivative liraglutide in rats with beta-cell deficiencies: influence of metabolic state on beta-cell mass dynamics. / Sturis, Jeppe; Gotfredsen, Carsten F; Rømer, John; Rolin, Bidda; Ribel, Ulla; Brand, Christian L; Wilken, Michael; Wassermann, Karsten; Deacon, Carolyn F; Carr, Richard D; Knudsen, Lotte Bjerre.

    In: British Journal of Pharmacology, Vol. 140, No. 1, 2003, p. 123-32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  204. Published

    Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia. / Meier, J.J.; Gallwitz, N.; Siepmann, N.; Holst, Jens Juul; Deacon, C.F.; Schmidt, W.E.; Nauck, M.A.

    In: Diabetologia, No. 46, 2003, p. 798-801.

    Research output: Contribution to journalJournal articleResearchpeer-review

  205. Published

    Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1. / Ugleholdt, Randi; Zhu, Xiaorong; Deacon, Carolyn F; Ørskov, Cathrine; Steiner, Donald F; Holst, Jens J.

    In: Endocrinology, Vol. 145, No. 3, 2003, p. 1349-55.

    Research output: Contribution to journalJournal articleResearchpeer-review

  206. Published

    Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both involved in regulating the metabolic stability of glucagon-like peptide-1 in vivo. / Plamboeck, Astrid; Holst, Jens J; Carr, Richard D; Deacon, Carolyn F.

    In: Advances in Experimental Medicine and Biology, Vol. 524, 2003, p. 303-12.

    Research output: Contribution to journalJournal articleResearchpeer-review

  207. Published

    Similar insulin secretory response to a gastric inhibitory polypeptide bolus injection at euglycemia in first-degree relatives of patients with type 2 diabetes and control subjects. / Meier, Juris J; Nauck, Michael A; Siepmann, Nina; Greulich, Michael; Holst, Jens J; Deacon, Carolyn F; Schmidt, Wolfgang E; Gallwitz, Baptist.

    In: Metabolism - Clinical and Experimental, Vol. 52, No. 12, 2003, p. 1579-85.

    Research output: Contribution to journalJournal articleResearchpeer-review

  208. Published

    The reduction in hepatic insulin clearance after oral glucose is not mediated by gastric inhibitory polypeptide (GIP). / Meier, Juris J; Gallwitz, Baptist; Siepmann, Nina; Holst, Jens J; Deacon, Carolyn F; Schmidt, Wolfgang E; Nauck, Michael A.

    In: Regulatory Peptides, Vol. 113, No. 1-3, 2003, p. 95-100.

    Research output: Contribution to journalJournal articleResearchpeer-review

  209. Published

    Valine pyrrolidide preserves intact glucose-dependent insulinotropic peptide and improves abnormal glucose tolerance in minipigs with reduced beta-cell mass. / Larsen, Marianne Olholm; Rolin, Bidda; Ribel, Ulla; Wilken, Michael; Deacon, Carolyn F; Svendsen, Ove; Gotfredsen, Carsten F; Carr, Richard David.

    In: Experimental Diabesity Research, Vol. 4, No. 2, 2003, p. 93-105.

    Research output: Contribution to journalJournal articleResearchpeer-review

  210. 2002
  211. Published

    Preservation of active incretin hormones by inhibition of dipeptidyl peptidase IV suppresses meal-induced incretin secretion in dogs. / Deacon, C F; Wamberg, S; Bie, P; Hughes, T E; Holst, Jens Juul.

    In: Journal of Endocrinology, Vol. 172, No. 2, 02.2002, p. 355-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  212. Published

    Dipeptidyl peptidase IV inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective. / Deacon, Carolyn F; Holst, Jens J.

    In: Biochemical and Biophysical Research Communications, Vol. 294, No. 1, 2002, p. 1-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  213. Published

    GLP-1-(9-36) amide reduces blood glucose in anesthetized pigs by a mechanism that does not involve insulin secretion. / Deacon, Carolyn F; Plamboeck, Astrid; Møller, Søren; Holst, Jens J.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 282, No. 4, 2002, p. E873-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  214. Published

    NN2211: a long-acting glucagon-like peptide-1 derivative with anti-diabetic effects in glucose-intolerant pigs. / Ribel, Ulla; Larsen, Marianne O; Rolin, Bidda; Carr, Richard D; Wilken, Michael; Sturis, Jeppe; Westergaard, Lisbet; Deacon, Carolyn F; Knudsen, Lotte Bjerre.

    In: European Journal of Pharmacology, Vol. 451, No. 2, 2002, p. 217-25.

    Research output: Contribution to journalJournal articleResearchpeer-review

  215. Published

    The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice. / Rolin, Bidda; Larsen, Marianne O; Gotfredsen, Carsten F; Deacon, Carolyn F; Carr, Richard D; Wilken, Michael; Knudsen, Lotte Bjerre.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 283, No. 4, 2002, p. E745-52.

    Research output: Contribution to journalJournal articleResearchpeer-review

  216. 2001
  217. Published

    Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs. / Deacon, C.F.; Danielsen, P.; Klarskov, L.; Holst, J.J.; Olesen, M.

    In: Diabetes, No. 50, 2001, p. 1588-1597.

    Research output: Contribution to journalJournal articleResearchpeer-review

  218. Published

    Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes. / Meier, J.J.; Huking, K.; Holst, J.J.; Deacon, C.F.; Schmiegel, W.H.; Nauck, M.A.

    In: Diabetes, No. 50, 2001, p. 2497-2504.

    Research output: Contribution to journalJournal articleResearchpeer-review

  219. 2000
  220. Published

    Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide. / Deacon, C.F.; Nauck, M.A.; Meier, J.; Hücking, K.; Holst, J.J.

    In: Journal of Clinical Endocrinology and Metabolism, No. 85, 2000, p. 3575-3581.

    Research output: Contribution to journalJournal articleResearchpeer-review

  221. Published

    In vivo and in vitro degradation of glucagon-like peptide-2 in humans. / Hartmann, Bolette; Harr, M.B.; Jeppesen, P.B.; Wojdemann, M.; Deacon, C.F.; Mortensen, P.B.; Holst, J.J.

    In: Journal of Clinical Endocrinology and Metabolism, No. 85, 2000, p. 2884-2888.

    Research output: Contribution to journalJournal articleResearchpeer-review

  222. 1999
  223. Published

    Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine. / Hansen, L; Deacon, C F; Orskov, C; Holst, J J.

    In: Molecular Endocrinology, Vol. 140, No. 11, 11.1999, p. 5356-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  224. Published

    Glucagon-like peptide-1 : a basis for new approaches to the management of diabetes. / Deacon, C F; Holst, Jens Juul; Carr, R D.

    In: Drugs of Today, Vol. 35, No. 3, 03.1999, p. 159-70.

    Research output: Contribution to journalJournal articleResearchpeer-review

  225. Published

    Glucagon-like peptide-1(7-36)amide is transformed to glucagon-like peptide-1 (9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the intestinal L-cells. / Hansen, L.; Deacon, C.F.; Ørskov, C.; Holst, J.J.

    In: Endokrinologiya, No. 140, 1999, p. 5356-5363.

    Research output: Contribution to journalJournal articleResearchpeer-review

  226. Published

    Glucagon-like peptide-1: A basis for new approaches to the management of Diabetes. / Deacon, C.F.; Holst, J.J.; Carr, R.D.

    In: Drugs of Today, No. 35, 1999, p. 159-170.

    Research output: Contribution to journalJournal articleResearchpeer-review

  227. 1998
  228. Published

    Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig. / Deacon, C.F.; Hughes, T.E.; Holst, J.J.

    In: Diabetes, No. 47, 1998, p. 764-769.

    Research output: Contribution to journalJournal articleResearchpeer-review

  229. Published

    Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity. / Deacon, C.F.; Knudsen, L.B.; Madsen, K.; Wiberg, F.C.; Jacobsen, O.; Holst, J.J.

    In: Diabetologia, No. 41, 1998, p. 271-278.

    Research output: Contribution to journalJournal articleResearchpeer-review

  230. Published

    Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes. / Holst, J.J.; Deacon, C.F.

    In: Diabetes, No. 47, 1998, p. 1663-1670.

    Research output: Contribution to journalJournal articleResearchpeer-review

  231. Published

    On the treatment of diabetes mellitus with glucagon-like peptide-1. / Holst, J.J.; Deacon, C.F.; Toft-Nielsen, M.; Bjerre-Knudsen, L.

    In: Annals of the New York Academy of Sciences, No. 865, 1998, p. 336-343.

    Research output: Contribution to journalJournal articleResearchpeer-review

  232. 1997
  233. Published

    Posttranslational processing of proglucagon and postsecretory fate of proglucagon products. / Holst, Jens Juul; Ørskov, C.; Hartmann, Bolette; Deacon, C.F.

    The Insulinotropic Gut Hormone Glucagon-like Peptide-1.. Basel : Karger, 1997. p. 24-48.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  234. 1996
  235. Published

    Plasma TNF-x is associated with insulin mediated suppression of free fatty acids and net lipid oxidation in HIV-infected patients with lipodystrophy. / Haugaard, S.B.; Andersen, O.; Pedersen, S.B.; Dela, Flemming; Deacon, C.F.

    In: Metabolism - Clinical and Experimental, No. 55(2), 1996, p. 175-182.

    Research output: Contribution to journalJournal articleResearchpeer-review

  236. 1995
  237. Published

    Both subcutaneously and intravenously administered glucagon-like peptide-1 are rapidly degraded from the amino terminus in type II diabetic patients and in healthy subjects. / Deacon, C.F.; Nauck, M.A.; Nielsen, M.T.; Pridal, L.; Holst, Jens Juul.

    In: Diabetes, No. 44, 1995, p. 1126-1131.

    Research output: Contribution to journalJournal articleResearchpeer-review

  238. Published

    Degradation of glucagon-like peptide-1 in vitro yields an N-terminally truncated peptide which is a major endogenous metabolite in vivo. / Deacon, C.F.; Johnsen, A.H.; Holst, Jens Juul.

    In: Journal of Clinical Endocrinology and Metabolism, No. 80, 1995, p. 952-957.

    Research output: Contribution to journalJournal articleResearchpeer-review

  239. Published

    Human colon produces fully processed glucagon-like peptide-1 (7-36 amide). / Deacon, C.F.; Johnsen, A.H.; Holst, Jens Juul.

    In: FEBS Letters, No. 372, 1995, p. 269-272.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 9220