Andreas Kjær

Andreas Kjær

Professor


  1. Published

    FLT-PET And FDG-PET/CT For The Detection Of Relapse Following Definitive Radiotherapy In Non-small Cell Lung Cancer: Preliminary Results

    Christensen, T., Langer, Seppo W., Larsen, K., Persson, Gitte F., Amtoft, A. G., Johannesen, H., Keller, S., Kjær, Andreas & Fischer, Barbara Malene Bjerregaard, 2019, In: Journal of Thoracic Oncology. 13, 105, p. S672 P2.01-20.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  2. Published

    FLT-PET for early response evaluation of colorectal cancer patients with liver metastases: a prospective study

    Mogensen, M. B., Loft, A., Aznar, M., Axelsen, T., Vainer, B., Osterlind, K. & Kjær, Andreas, 2017, In: E J N M M I Research. 7, 9 p., 56.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Feasibility and Implication of Routine NGS Analysis in Neuroendocrine Carcinomas

    Knigge, Ulrich, Federspiel, B., Andreassen, Mikkel, Kjær, Andreas & Langer, Seppo W., 2017, In: Neuroendocrinology. 105, S1, p. 26-26 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  4. E-pub ahead of print

    Feasibility and diagnostic performance of sentinel node biopsy for staging cN0 oral squamous cell carcinoma in a previously treated neck

    Mørch, T., Tvedskov, Jesper Filtenborg, Wessel, Irene , Charabi, Birgitte Wittenborg, Jakobsen, K. K., Grønhøj, Christian, Kiss, K., Lelkaitis, G., Mortensen, Jann, Kjær, Andreas, von Buchwald, Christian & Christensen, Anders, 2024, (E-pub ahead of print) In: World Journal of Otorhinolaryngology - Head and Neck Surgery.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Feasibility of Multiparametric Imaging with PET/MR in Head and Neck Squamous Cell Carcinoma

    Rasmussen, J. H., Nørgaard, M., Hansen, A. E., Vogelius, Ivan R. , Aznar, M. C., Johannesen, H. H., Costa, J., Engberg, A. M. E., Kjær, Andreas, Specht, Lena & Fischer, Barbara Malene Bjerregaard, Jan 2017, In: The Journal of Nuclear Medicine. 58, 1, p. 69-74 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Feasibility of Multiparametric Positron Emission Tomography/Magnetic Resonance Imaging as a One-Stop Shop for Radiation Therapy Planning for Patients with Head and Neck Cancer

    Olin, A. B., Hansen, Adam Espe, Rasmussen, J. H., Ladefoged, C. N., Berthelsen, A. K., Håkansson, K., Vogelius, Ivan R. , Specht, Lena, Gothelf, A. B., Kjær, Andreas, Fischer, Barbara Malene Bjerregaard & Andersen, Flemming Littrup, 2020, In: International Journal of Radiation Oncology Biology Physics. 108, 5, p. 1329-1338 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Feasibility of Real-Time Near-Infrared Fluorescence Tracer Imaging in Sentinel Node Biopsy for Oral Cavity Cancer Patients

    Christensen, Anders, Stræde, Karina, Charabi, Birgitte Wittenborg, Mortensen, Jann, Kiss, K., Kjær, Andreas & von Buchwald, Christian, Feb 2016, In: Annals of Surgical Oncology. 23, 2, p. 565-72 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Feasibility of multi-parametric PET and MRI for prediction of tumour recurrence in patients with glioblastoma

    Lundemann, M., af Rosenschold, P. M., Muhic, A., Larsen, V. A., Poulsen, H. S., Engelholm, S., Andersen, Flemming Littrup, Kjær, Andreas, Larsson, Henrik Bo Wiberg, Law, Ian & Hansen, Adam Espe, 2019, In: European Journal of Nuclear Medicine and Molecular Imaging. 46, 3, p. 603-613

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Feasibility of positron range correction in 82-Rubidium cardiac PET/CT

    Jensen, Malte Engmann Kjeldskov, Bentsen, Simon, Clemmensen, Andreas Høeg, Jensen, Jacob Kildevang, Madsen, Johanne Straarup, Rossing, J., Laier, A., Hasbak, P., Kjær, Andreas & Ripa, Rasmus Sejersten, 2022, In: EJNMMI Physics. 9, 1, 18 p., 51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Feasibility of simultaneous PET/MR in diet-induced atherosclerotic minipig: a pilot study for translational imaging

    Pedersen, S. F., Ludvigsen, Trine Pagh, Johannesen, Helle Hjorth, Löfgren, J., Ripa, Rasmus Sejersten, Hansen, Adam Espe, Ettrup, A. J., Christoffersen, B. Ø., Pedersen, H. D., Olsen, Lisbeth Høier, Højgaard, Liselotte & Kjær, Andreas, 2014, In: American Journal of Nuclear Medicine and Molecular Imaging. 4, 5, p. 448-58 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Feasibility of simultaneous PET/MR of the carotid artery: first clinical experience and comparison to PET/CT

    Ripa, Rasmus Sejersten, Knudsen, A., Hag, Anne Mette Fisker, Lebech, Anne-Mette, Loft, A., Keller, S. H., Hansen, Adam Espe, von Benzon, E., Højgaard, Liselotte & Kjær, Andreas, 2013, In: American Journal of Nuclear Medicine and Molecular Imaging. 3, 4, p. 361-371 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Fever of unknown origin: prospective comparison of diagnostic value of 18F-FDG PET and 111In-granulocyte scintigraphy.

    Kjær, Andreas, Lebech, A., Eigtved, A. & Højgaard, Liselotte, 2004, In: European Journal of Nuclear Medicine and Molecular Imaging. 31, 5, p. 622-6 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    First (18)F-labeled ligand for PET imaging of uPAR: In vivo studies in human prostate cancer xenografts

    Persson, M., Liu, H., Madsen, J., Cheng, Z. & Kjær, Andreas, Jul 2013, In: Nuclear Medicine and Biology. 40, 5, p. 618-24 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    First-In-Human Study of [68Ga]Ga-NODAGA-E[c(RGDyK)]2 PET for Integrin αvβ3 Imaging in Patients with Breast Cancer and Neuroendocrine Neoplasms: Safety, Dosimetry and Tumor Imaging Ability

    Clausen, Malene Martini, Carlsen, E. A., Christensen, C., Madsen, J., Brandt-Larsen, M., Klausen, Thomas Levin, Holm, S., Loft, A., Berthelsen, A. K., Kroman, Niels Thorndahl, Knigge, Ulrich & Kjær, Andreas, 2022, In: Diagnostics. 12, 4, 15 p., 851.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    First-in-Human PET Imaging of Tissue Factor in Patients with Primary and Metastatic Cancers Using 18F-labeled Active-Site Inhibited Factor VII (18F-ASIS): Potential as Companion Diagnostic

    Loft, Mathias Hougaard, Christensen, C., Clausen, Malene Martini, Carlsen, Esben Andreas, Hansen, C. P., Kroman, Niels Thorndahl, Langer, Seppo W., Høgdall, Claus Kim, Madsen, J., Gillings, N., Nielsen, Carsten Haagen, Klausen, Thomas Levin, Holm, S., Loft, A., Berthelsen, A. K. & Kjær, Andreas, 2022, In: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 63, 12, p. 1871-1879

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    First-in-human uPAR PET: Imaging of Cancer Aggressiveness

    Persson, M., Skovgaard, D., Brandt-Larsen, M., Christensen, C., Madsen, J., Nielsen, Carsten Haagen, Røndbjerg, T. T., Klausen, Thomas Levin, Holm, S., Loft, A., Berthelsen, A. K., Ploug, Michael, Pappot, H., Brasso, K., Kroman, Niels Thorndahl, Højgaard, Liselotte & Kjær, Andreas, 2015, In: Theranostics. 5, 12, p. 1303-16 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    First-line treatment of patients with disseminated poorly differentiated neuroendocrine carcinomas with carboplatin, etoposide, and vincristine: a single institution experience

    Olsen, I. H., Langer, S. W., Jepsen, I., Assens, M., Federspiel, B., Hasselby, J. P., Hansen, C. P., Kjær, Andreas & Knigge, Ulrich, 2012, In: Acta Oncologica. 51, 1, p. 97-100 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Flourine-18 labelling of a series of potential EGFRvIII targeting peptides with a parallel labelling approach using [18F]FPyME

    Denholt, C. L., Kuhnast, B., Dollé, F., Hinnen, F., Hansen, P. R., Gillings, N., Kjær, Andreas, Denholt, C. L., Kuhnast, B., Dollé, F., Hinnen, F., Hansen, P. R., Gillings, N. & Kjær, Andreas, 2010, In: Journal of Labelled Compounds and Radiopharmaceuticals. 53, p. 774-778

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Flow Cytometric Evaluation of the Ongoing Angiogenic Response in Rat Cardiac Tissue Following Myocardial Infarction

    Pedersen, Cecilie Høeg, Ringgaard, L., Christensen, E., Follin, Bjarke, Bentsen, Simon, Ripa, Rasmus Sejersten & Kjær, Andreas, 2021, In: Current Protocols. 1, 2, 14 p., e40.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Flow-Mediated Vasodilatation and Intima-Media Thickness in Patients with Coexisting Heart Failure and Diabetes Receiving Medical Therapy

    Andersen, L. V., Wiinberg, N., Tuxen, C. D. & Kjær, Andreas, 2011, In: Diagnostic. 1, 1, p. 38-52 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Fluorine-18 labeled aldehydes as prosthetic groups for oxime coupling with a FVIIa protein

    Jeppesen, T. E., Kristensen, J. B., Behrens, C., Madsen, J. & Kjær, Andreas, 2021, In: Journal of Labelled Compounds and Radiopharmaceuticals. 64, 5, p. 198-208

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Fluorine-18 radiolabeling strategies-advantages and disadvantages of currently applied labeling methods

    Edem, P. E., Steen, E. J. L., Kjær, Andreas & Herth, Matthias Manfred, 2019, Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates. Elsevier, p. 29-103

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  23. Published

    Folate receptor targeting of radiolabeled liposomes reduces intratumoral liposome accumulation in human KB carcinoma xenografts

    Christensen, E., Henriksen, J. R., Jørgensen, Jesper Tranekjær, Amitay, Y., Shmeeda, H., Gabizon, A. A., Kjær, Andreas, Andresen, T. L. & Hansen, A. E., 2018, In: International Journal of Nanomedicine. 13, p. 7647-7656

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Four weeks treatment with the GLP-1 receptor analogue liraglutide lowers liver fat and concomitantly circulating glucagon in individuals with overweight

    Svane, M. S., Johannesen, H. H., Hansen, Adam Espe, Martinussen, C., Bojsen-Møller, K. N., Hansen, M. L., Deacon, Carolyn F., Keller, S. H., Klausen, Thomas Levin, Loft, A., Kjær, Andreas, Löfgren, J., Madsbad, Sten, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2022, In: International Journal of Obesity. 46, 11, p. 2058–2062 8 p.

    Research output: Contribution to journalLetterResearchpeer-review

  25. Published

    FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function

    Jensen, K. S., Binderup, Tina, Jensen, K. T., Therkelsen, I., Borup, R., Nilsson, E., Multhaupt, Hinke Arnolda B V H, Bouchard, C., Quistorff, B., Kjær, Andreas, Landberg, G. & Staller, P., 16 Nov 2011, In: E M B O Journal. 30, 22, p. 4554-70 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Fractionated photothermal therapy in a murine tumor model: comparison with single dose

    Simón, M., Nørregaard, K., Jørgensen, Jesper Tranekjær, Oddershede, L. B. & Kjær, Andreas, Jul 2019, In: International Journal of Nanomedicine. 14, p. 5369—5379

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Fully Automated, Fast Motion Correction of Dynamic Whole-Body and Total-Body PET/CT Imaging Studies

    Sundar, L. K. S., Lassen, Martin Lyngby, Gutschmayer, S., Ferrara, D., Calabrò, A., Yu, J., Kluge, K., Wang, Y., Nardo, L., Hasbak, P., Kjær, Andreas, Abdelhafez, Y. G., Wang, G., Cherry, S. R., Spencer, B. A., Badawi, R. D., Beyer, T. & Muzik, O., 2023, In: Journal of Nuclear Medicine. 64, 7, p. 1145-1153

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Functional brown adipose tissue and sympathetic activity after cold exposure in humans with type 1 narcolepsy

    Enevoldsen, L. H., Tindborg, M., Hovmand, N. L., Christoffersen, Christina, Ellingsgaard, H., Suetta, Charlotte, Stallknecht, Bente Merete, Jennum, Poul, Kjær, Andreas & Gammeltoft, S., 2018, In: Sleep. 41, 8, p. 1-9 zsy092.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Functional imaging of neuroendocrine tumors: a head-to-head comparison of somatostatin receptor scintigraphy, 123I-MIBG scintigraphy, and 18F-FDG PET

    Binderup, Tina, Knigge, Ulrich, Loft, A., Mortensen, Jann, Pfeifer, A., Federspiel, B., Hansen, C. P., Højgaard, Liselotte, Kjær, Andreas, Binderup, T., Knigge, Ulrich, Jakobsen, A. L., Mortensen, Jann, Pfeifer, A., Federspiel, B. H., Hansen, C. P., Højgaard, Liselotte & Kjær, Andreas, 1 May 2010, In: Journal of Nuclear Medicine. 51, 5, p. 704-12 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Gastroenteropancreatic (GEP) Mixed Neuroendocrine-Non-Endocrine Neoplasms (MiNEN)

    Laenkholm, I. T., Langer, Seppo W., Andreassen, Mikkel, Holmager, P., Hansen, C. P., Kjær, Andreas, Federspiel, B. & Knigge, Ulrich, 2019, p. 244-244. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  31. Published

    Gene Expression of Glucose Transporter 1 (GLUT1), Hexokinase 1 and Hexokinase 2 in Gastroenteropancreatic Neuroendocrine Tumors: Correlation with F-18-fluorodeoxyglucose Positron Emission Tomography and Cellular Proliferation

    Binderup, Tina, Knigge, Ulrich, Federspiel, B. H., Sommer, P., Hasselby, Jane Preuss, Loft Jakobsen, A. & Kjær, Andreas, Dec 2013, In: Diagnostics. 3, 4, p. 372-84 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Gene expression and 18FDG uptake in atherosclerotic carotid plaques

    Pedersen, S. F., Græbe, Martin, Hag, Anne Mette Fisker, Højgaard, Liselotte, Sillesen, Henrik, Kjær, Andreas, Pedersen, S. F., Græbe, M., Hag, A. M. F., Højgaard, Liselotte, Sillesen, H. H. & Kjær, Andreas, 1 May 2010, In: Nuclear Medicine Communications. 31, 5, p. 423-9 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Gene expression of ANP, BNP and ET-1 in the heart of rats during pulmonary embolism

    Borgwardt, H. G., Oxbøl, J., Kristoffersen, U. S., Mortensen, Jann & Kjær, Andreas, 1 Jan 2010, In: P L o S One. 5, 6, p. e11111

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Gene expression of LOX-1, VCAM-1, and ICAM-1 in pre-atherosclerotic mice.

    Hag, Anne Mette Fisker, Pedersen, S. F. & Kjær, Andreas, 2008, In: Biochemical and Biophysical Research Communications. 377/2, p. 689-693 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Geometric distortions of diffusion weighted imaging of the head/neck in combined PET/MR: optimization of image acquisition and post-processing correction for oncology applications

    Hansen, Adam Espe, Rasmussen, J., Johannesen, H. H., Engberg, A. M., Andersen, F. L., Specht, Lena, Kjær, Andreas, Højgaard, Liselotte, Beyer, T. & Fischer, Barbara Malene Bjerregaard, Jul 2014, In: E J N M M I Physics. 1, Suppl 1, 2 p., A76.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  36. Published

    Goblet cell carcinoids: characteristics of a Danish cohort of 83 patients

    Olsen, I. H., Holt, N., Langer, Seppo W., Hasselby, J. P., Grønbæk, H., Hillingsø, Jens Georg, Mahmoud, M., Ladekarl, M., Iversen, L. H., Kjær, Andreas, Federspiel, B. H. & Knigge, Ulrich, 2015, In: P L o S One. 10, 2, p. 1-17 17 p., e0117627.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Guideline for PET/CT imaging of neuroendocrine neoplasms withGa-DOTA-conjugated somatostatin receptor targeting peptides andF-DOPA

    Bozkurt, M. F., Virgolini, I., Balogova, S., Beheshti, M., Rubello, D., Decristoforo, C., Ambrosini, V., Kjær, Andreas, Delgado-Bolton, R., Kunikowska, J., Oyen, W. J. G., Chiti, A., Giammarile, F. & Fanti, S., Aug 2017, In: European Journal of Nuclear Medicine and Molecular Imaging. 44, 9, p. 1588-1601 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    H3 receptor modulation of neuroendocrine responses to histamine and stress

    Knigge, Ulrich, Kjær, Andreas, Jørgensen, H. & Warberg, J., 1998, The Histamine H3 Receptor. Elsevier, p. 41-58

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  39. Published

    HIV infection and arterial inflammation assessed by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET): A prospective cross-sectional study

    Knudsen, A., Hag, Anne Mette Fisker, Loft, A., von Benzon, E., Keller, S. H., Møller, H. J., Lebech, Anne-Mette, Ripa, Rasmus Sejersten & Kjær, Andreas, Apr 2015, In: Journal of Nuclear Cardiology. 22, 2, p. 372-80 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Head-to-head comparison of 64Cu-DOTATATE and 68Ga-DOTATOC PET/CT: a prospective study of 59 patients with neuroendocrine tumors

    Johnbeck, C. B., Knigge, Ulrich, Loft, A., Berthelsen, A. K., Mortensen, Jann, Oturai, P., Langer, Seppo W., Elema, D. & Kjær, Andreas, Mar 2017, In: The Journal of Nuclear Medicine. 58, 3, p. 451-457 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Heart failure and neuroendocrine activation: Diagnostic, prognostic and therapeutic perspectives

    Kjær, Andreas & Hesse, B., 2001, In: Clinical Physiology. 21, 6, p. 661-672 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Hepatitis C virus infection and risk of coronary artery disease: a systematic review of the literature

    Roed, T., Lebech, Anne-Mette, Kjær, Andreas & Weis, Nina, 2012, In: Clinical Physiology and Functional Imaging. 32, 6, p. 421-30 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    High tumor uptake of (64)Cu: implications for molecular imaging of tumor characteristics with copper-based PET tracers

    Jørgensen, Jesper Tranekjær, Persson, M., Madsen, J. & Kjær, Andreas, Apr 2013, In: Nuclear Medicine and Biology. 40, 3, p. 345-50 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Histamine and prostaglandin interaction in regulation of oxytocin and vasopressin secretion

    Knigge, Ulrich, Kjær, Andreas, Kristoffersen, U., Madsen, K., Miranda, C. L. T., Jørgensen, H. & Warberg, J., 2003, In: Journal of Neuroendocrinology. 15, p. 940-945

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Histamine and prostaglandin interaction in the central regulation of ACTH secretion.

    Anthonisen, M., Knigge, U., Kjær, Andreas & Warberg, J., 1997, In: Neuroendocrinology. 66, p. 68-74

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Histamine and the regulation of body weight.

    Jørgensen, E. A., Knigge, Ulrich, Warberg, J. & Kjær, Andreas, 2007, In: Neuroendocrinology. 86, 3, p. 210-4 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Histamine stimulates c-fos expression in hypothalamic vasopressin-, oxytocin-, and corticotropin-releasing hormone-containing neurons

    Kjær, Andreas, Larsen, P. J., Knigge, Ulrich, Møller, Morten & Warberg, J., Jan 1994, In: Endocrinology. 134, 1, p. 482-491 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Histamine stimulates c-fos expression in hypothalamic vasopressin-, oxytocin-, and coticotropin-releasing hormone-containing neurons

    Kjær, Andreas, Larsen, P. J., Knigge, U., Møller, M. & Warberg, J., 1994, In: Endokrinologiya. 134, p. 482-491

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Histamine- and stress-induced prolactin secretion: Importance of vasopressin V1- and V2-receptors

    Kjær, Andreas, Knigge, Ulrich & Warberg, J., 1994, In: European Journal of Endocrinology. 131, 4, p. 391-397 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Histamine- and stress-induced prolactin secretion: importance of vasopressin V*U1 and V*U2-receptors

    Kjær, Andreas, Knigge, U. & Warberg, J., 1994, In: Eur J of Endocrinology. 131, p. 391-7

    Research output: Contribution to journalJournal articleResearchpeer-review

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