Birgitte Holst
Guest Researcher
Endocrinology and Metabolism
Blegdamsvej 3
2200 København N.
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FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver
von Holstein-Rathlou, S., BonDurant, L. D., Peltekian, L., Naber, M. C., Yin, T. C., Claflin, K. E., Urizar, A. I., Madsen, A. N., Ratner, C., Holst, B., Karstoft, K., Vandenbeuch, A., Anderson, C. B., Cassell, M. D., Thompson, A. P., Solomon, T. P., Rahmouni, K., Kinnamon, S. C., Pieper, A. A., Gillum, M. P. & 1 others, , 9 Feb 2016, In: Cell Metabolism. 23, 2, p. 335-43 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ablation of Nampt in AgRP neurons leads to neurodegeneration and impairs fasting- and ghrelin-mediated food intake
de Guia, R. M., Hassing, Anna Skab, Ma, Tao, Plucinska, Kaja, Holst, Birgitte, Gerhart-Hines, Zach, Emanuelli, Brice & Treebak, Jonas Thue, 2021, In: F A S E B Journal. 35, 5, e21450.Research output: Contribution to journal › Journal article › Research › peer-review
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Fasting- and ghrelin-induced food intake is regulated by NAMPT in the hypothalamus
de Guia, R. M., Hassing, Anna Skab, Skov, Louise Julie, Ratner, C., Plucinska, Kaja, Madsen, S., Diep, T. A., dela Cruz, Gelo, Trammell, Sam, Sustarsic, E. G., Emanuelli, Brice, Gillum, M. P., Gerhart-Hines, Zach, Holst, Birgitte & Treebak, Jonas Thue, 2020, In: Acta Physiologica. 228, 4Research output: Contribution to journal › Journal article › Research › peer-review
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Estrous Cycle Modulation of Feeding and Relaxin-3/Rxfp3 mRNA Expression: Implications for Estradiol Action
de Avila, C., Chometton, S., Calvez, J., Guevremont, G., Kania, A., Pedersen, Lola Julie Torz, Lenglos, C., Blasiak, A., Rosenkilde, Mette, Holst, Birgitte, Conrad, C. D., Fyer, J. D., Timofeeva, E., Gundlach, A. L. & Cifani, C., 2021, In: Neuroendocrinology. 111, 12, p. 1201–1218Research output: Contribution to journal › Journal article › Research › peer-review
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Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice
Wellner, N., Tsuboi, K., Madsen, A. N., Holst, Birgitte, Diep, T. A., Nakao, M., Tokumura, A., Burns, M. P., Deutsch, D. G., Ueda, N. & Hansen, Harald S., 1 Sep 2011, In: BBA General Subjects. 1811, 9, p. 508-12 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional and genetic epidemiological characterisation of the FFAR4 (GPR120) p.R270H variant in the Danish population
Vestmar, M. A., Galijatovic, E. A. A., Christensen, C. R., Pedersen, M. H., Glümer, C., Linneberg, Allan René, Witte, D. R., Jørgensen, M. E., Christensen, C., Brandslund, I., Lauritzen, T., Pedersen, Oluf Borbye, Holst, Birgitte, Grarup, Niels, Schwartz, Thue W. & Hansen, Torben, Sep 2016, In: Journal of Medical Genetics. 53, 9, p. 616-23 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PheVI:09 (Phe6.44) as a sliding microswitch in seven-transmembrane (7TM) G protein-coupled receptor activation
Valentin-Hansen, L., Holst, Birgitte, Frimurer, Thomas Michael, Schwartz, Thue W. & Hansen, L. V., 21 Dec 2012, In: Journal of Biological Chemistry. 287, 52, p. 43516-43526 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Metabolic insights from a GHSR-A203E mutant mouse model
Pedersen, Lola Julie Torz, Osborne-Lawrence, S., Rodriguez, J., He, Z., Paula Cornejo, M., Roman Mustafa, E., Jin, C., Petersen, N., Hedegaard, M. A., Nybo, Maja Lind, Martinez Damonte, V., Metzger, N. P., Mani, B. K., Williams, K. W., Raingo, J., Perello, M., Holst, Birgitte & Zigman, J. M., 2020, In: Molecular Metabolism. 39, 16 p., 101004.Research output: Contribution to journal › Journal article › Research › peer-review
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High molecular weight PEGylation of human pancreatic polypeptide at position 22 improves stability and reduces food intake in mice
Thieme, V., Jolly, N., Madsen, A. N., Bellmann-Sickert, K., Schwartz, Thue W., Holst, Birgitte, Cox, H. M. & Beck-Sickinger, A. G., Nov 2016, In: British Journal of Pharmacology. 173, 22, p. 3208-3221 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Physiological and Pathological Impact of Blood Sampling by Retro-Bulbar Sinus Puncture and Facial Vein Phlebotomy in Laboratory Mice
Teilmann, A. C., Nygaard Madsen, A., Holst, Birgitte, Hau, Jann, Rozell, B. & Abelson, Klas, 26 Nov 2014, In: PloS one. 9, 11, p. 1-19 19 p., e113225.Research output: Contribution to journal › Journal article › Research › peer-review
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New potential agents for cryopreservation of hematopoietic and adipose stromal cells
Svalgaard, J., Haastrup, E., Brink, A., Clausen, C., Holst, Birgitte, Theilgaard-Mønch, Kim, Reckzeh, K. & Fischer-Nielsen, A., Apr 2014, In: Cytotherapy. 16, Supplement 4, p. S58Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39
Storjohann, L., Holst, Birgitte & Schwartz, Thue W., 2008, In: FEBS Letters. 582, 17, p. 2583-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A second disulfide bridge from the N-terminal domain to extracellular loop 2 dampens receptor activity in GPR39
Storjohann, L., Holst, Birgitte & Schwartz, Thue W., 2008, In: Biochemistry. 47, 35, p. 9198-207 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Acute disruption of glucagon secretion or action does not improve glucose tolerance in an insulin-deficient mouse model of diabetes
Steenberg, V. R., Jensen, S. M., Pedersen, Jens, Madsen, A. N., Windeløv, Johanne Agerlin, Holst, Birgitte, Quistorff, B., Poulsen, Steen Seier & Holst, Jens Juul, 2016, In: Diabetologia. 59, 2, p. 363-370 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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RhoA in tyrosine hydroxylase neurons regulates food intake and body weight via altered sensitivity to peripheral hormones
Skov, Louise Julie, Ratner, C., Hansen, Nikolaj Winther, Thompson, J. J., Egerod, Kristoffer Lihme, Burm, Hayley Beth, Dalbøge, L. S., Hedegaard, M. A., Brakebusch, Cord Herbert, Pers, Tune H, Perrier, Jean-Francois Marie & Holst, Birgitte, 2019, In: Journal of Neuroendocrinology. 31, 7, 13 p., UNSP e12761.Research output: Contribution to journal › Conference article › Research › peer-review
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Exploring the Behavioral and Metabolic Phenotype Generated by Re-Introduction of the Ghrelin Receptor in the Ventral Tegmental Area
Skov, Louise Julie, Jensen, M., Christiansen, S. H., Ratner, C., Woldbye, David Paul Drucker & Holst, Birgitte, 26 Apr 2017, In: International Journal of Molecular Sciences. 18, 5, 17 p., 914.Research output: Contribution to journal › Journal article › Research › peer-review
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Unique interaction pattern for a functionally biased ghrelin receptor agonist
Sivertsen, B. B., Lang, M., Frimurer, T. M., Holliday, N. D., Bach, Anders, Els, S., Engelstoft, M. S., Petersen, P. S., Madsen, A. N., Schwartz, Thue W., Beck-Sickinger, A. G. & Holst, Birgitte, 10 Jun 2011, In: The Journal of Biological Chemistry. 286, 23, p. 20845-20860 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functionally biased signalling properties of 7TM receptors - opportunities for drug development for the ghrelin receptor
Sivertsen, B., Holliday, N., Madsen, A. N. & Holst, Birgitte, Dec 2013, In: British Journal of Pharmacology. 170, 7, p. 1349-62 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A systematic review and meta-analysis finds increased blood levels of all forms of ghrelin in both restricting and binge-eating/purging subtypes of anorexia nervosa
Seidel, M., Jensen, S. M., Healy, D., Dureja, A., Watson, H. J., Holst, Birgitte, Bulik, C. M. & Sjögren, J. M., 2021, In: Nutrients. 13, 2, p. 1-19 19 p., 709.Research output: Contribution to journal › Review › Research › peer-review
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Risperidone treatment increases CB1 receptor binding in rat brain
Secher, A., Husum, H., Holst, Birgitte, Egerod, Kristoffer Lihme & Mellerup, Erling Thyge, 2010, In: Neuroendocrinology. 91, 2, p. 155-68 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular structure and function of 7TM/G-protein coupled receptors
Schwartz, Thue W. & Holst, Birgitte, 2002, Textbook of receptor Pharmacology. p. 65-84Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research
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Ago-allosteric modulation and other types of allostery in dimeric 7TM receptors
Schwartz, Thue W. & Holst, Birgitte, 2006, In: Journal of Receptors and Signal Transduction. 26, 1-2, p. 107-28 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act?
Schwartz, Thue W. & Holst, Birgitte, 2007, In: TIPS - Trends in Pharmacological Sciences. 28, 8, p. 366-73 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular mechanism of 7TM receptor activation--a global toggle switch model
Schwartz, Thue W., Frimurer, T. M., Holst, Birgitte, Rosenkilde, Mette & Elling, C. E., 2006, In: Annual Review of Pharmacology and Toxicology. 46, p. 481-519 38 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An enteroendocrine full package solution
Schwartz, Thue W. & Holst, Birgitte, 2010, In: Cell Metabolism. 11, 6, p. 445-7 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ghrelin-mediated improvements in the metabolic phenotype in the R6/2 mouse model of Huntington's disease
Rudenko, Olga, Springer, C., Skov, Louise Julie, Madsen, A. N., Hasholt, Lis Frydenreich, Nørremølle, Anne & Holst, Birgitte, 2019, In: Journal of Neuroendocrinology. 31, 7 (SI), 14 p., e12699.Research output: Contribution to journal › Conference article › Research › peer-review
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Natural agonist enhancing bis-His zinc-site in transmembrane segment V of the tachykinin NK3 receptor
Rosenkilde, Mette, Lucibello, M., Holst, Birgitte & Schwartz, Thue W., 1998, In: FEBS Letters. 439, 1-2, p. 35-40 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery
Ratner, C., Skov, Louise Julie, Raida, Z., Bächler, T., Bellmann-Sickert, K., Le Foll, C., Sivertsen, B., Dalbøge, L. S., Hartmann, Bolette, Beck-Sickinger, A. G., Madsen, A. N., Jelsing, J., Holst, Jens Juul, Lutz, T. A., Andrews, Z. B. & Holst, Birgitte, Sep 2016, In: Endocrinology. 157, 9, p. 3482-92 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Long-Acting Neurotensin Synergizes With Liraglutide to Reverse Obesity Through a Melanocortin-Dependent Pathway
Ratner, C., He, Z., Grunddal, Kaare Villum, Skov, Louise Julie, Hartmann, Bolette, Zhang, F., Feuchtinger, A., Bjerregaard, Anette, Christoffersen, Christina, Tschöp, M. H., Finan, B., DiMarchi, R. D., Leinninger, G. M., Williams, K. W., Clemmensen, Christoffer & Holst, Birgitte, 2019, In: Diabetes. 68, 6, p. 1329-1340Research output: Contribution to journal › Journal article › Research › peer-review
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Anorexia and fat aversion induced by vertical sleeve gastrectomy is attenuated in neurotensin receptor 1–Deficient mice
Ratner, C., Shin, J. H., Dwibedi, C., Tremaroli, V., Bjerregaard, Anette, Hartmann, Bolette, Bäckhed, F., Leinninger, G., Seeley, R. J. & Holst, Birgitte, 2021, In: Endocrinology. 162, 9, 12 p., bqab130.Research output: Contribution to journal › Journal article › Research › peer-review
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The metabolic actions of neurotensin secreted from the gut
Ratner, C., Johnsen, Cecilie Hundahl & Holst, Birgitte, Sep 2016, In: Cardiovascular Endocrinology. 5, 3, p. 102-111Research output: Contribution to journal › Review › Research › peer-review
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Impaired oxidative capacity due to decreased CPT1b levels as a contributing factor to fat accumulation in obesity
Ratner, C., Madsen, A. N., Kristensen, L. V., Skov, Louise Julie, Pedersen, K. S., Mortensen, Ole Hartvig, Knudsen, Gitte Moos, Raun, K. & Holst, Birgitte, 8 Apr 2015, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 308, 11, p. R973-R982 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Short-term effects of dietary advanced glycation end products in rats
Poulsen, M. W., Andersen, J. M., Hedegaard, R. S. V., Madsen, A. N., Krath, B. N., Monosik, R., Bak, M. J., Nielsen, J., Holst, Birgitte, Skibsted, Leif Horsfelt, Larsen, L. H. & Dragsted, Lars Ove, 2016, In: British Journal of Nutrition. 115, 4, p. 629-636 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In vivo characterization of high Basal signaling from the ghrelin receptor
Petersen, P. S., Woldbye, David Paul Drucker, Madsen, A. N., Egerod, Kristoffer Lihme, Jin, C., Lang, M., Rasmussen, M., Beck-Sickinger, A. G. & Holst, Birgitte, 2009, In: Endocrinology. 150, 11, p. 4920-30 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Deficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolism
Petersen, P. S., Jin, C., Madsen, A. N., Rasmussen, M., Kuhre, Rune Ehrenreich, Egerod, Kristoffer Lihme, Nielsen, L. B., Schwartz, Thue W. & Holst, Birgitte, 22 Jul 2011, In: FASEB Journal. p. 3803-3814 12 p., 4.Research output: Contribution to journal › Journal article › Research › peer-review
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Modifying the conserved C-terminal tyrosine of the peptide hormone PYY3-36 to improve Y2 receptor selectivity
Pedersen, S. L., Holst, Birgitte, Vrang, N. & Jensen, Knud Jørgen, 2009, In: Journal of Peptide Science. 15, 11, p. 753-759 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Peptide hormone isoforms: N-terminally branched PPY3-36 isoforms give improved lipid and fat-cell metabolism in diet-induced obese mice
Pedersen, S. L., Sasikumar, P. G., Chelur, S., Holst, Birgitte, Artmann, A., Jensen, Knud Jørgen & Vrang, N., 2010, In: Journal of Peptide Science. 16, 11, p. 664-673 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helix variants of PYY3-36
Pedersen, S. L., Bhatia, V. K., Jurt, S., Paulsson, J. F., Pedersen, M. H., Jørgensen, R., Holst, Birgitte, Stamou, Dimitrios, Vrang, N., Zerbe, O. & Jensen, Knud Jørgen, 2012, In: Journal of Peptide Science. 18, 9, p. 579-587 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GPR40 (FFAR1) – Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo
Pedersen, M. H., Bentsen, M. A., Husted, Anna Sofie, Ekberg, J. P., Wright, M. J., Di Salvo, J., Weinglass, A. B., Engelstoft, M. S., Madsen, A. N., Lückmann, Michael, Miller, M. W., Trujillo, M. E., Frimurer, Thomas Michael, Holst, Birgitte, Howard, A. D. & Schwartz, Thue W., Jan 2015, In: Molecular Metabolism. 4, 1, p. 3-14 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bioorthogonal Labeling of Ghrelin Receptor to Facilitate Studies of Ligand-Dependent Conformational Dynamics
Park, M., Sivertsen, B. B., Els-Heindl, S., Huber, T., Holst, Birgitte, Beck-Sickinger, A. G., Schwartz, Thue W. & Sakmar, T. P., 19 Nov 2015, In: Chemistry & Biology. 22, 11, p. 1431-1436 6 p.Research output: Contribution to journal › Letter › Research › peer-review
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The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo
Panaro, B. L., Tough, I. R., Engelstoft, M. S., Matthews, R. T., Digby, G. J., Møller, C. L., Svendsen, B., Gribble, F., Reimann, F., Holst, Jens Juul, Holst, Birgitte, Schwartz, Thue W., Cox, H. M. & Cone, R. D., 2 Dec 2014, In: Cell Metabolism. 20, 6, p. 1018-29 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Y5 neuropeptide Y receptor overexpression in mice neither affects anxiety- and depression-like behaviours nor seizures but confers moderate hyperactivity.
Olesen, M. V., Christiansen, S. H. O., Gøtzsche, C. R., Holst, Birgitte, Kokaia, M. & Woldbye, David Paul Drucker, 2012, In: Neuropeptides (Sheffield). 46, 2, p. 71-9Research output: Contribution to journal › Journal article › Research › peer-review
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Ligand binding and micro-switches in 7TM receptor structures
Nygaard, R., Frimurer, T. M., Holst, Birgitte, Rosenkilde, Mette & Schwartz, Thue W., 2009, In: TIPS - Trends in Pharmacological Sciences. 30, 5, p. 249-59 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Immune malfunction in the GPR39 zinc receptor of knockout mice: Its relationship to depressive disorder
Młyniec, K., Trojan, E., Ślusarczyk, J., Głombik, K., Basta-Kaim, A., Budziszewska, B., Skrzeszewski, J., Siwek, A., Holst, Birgitte & Nowak, G., 15 Feb 2016, In: Journal of Neuroimmunology. 291, p. 11-17 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GPR39 Zn2+-sensing receptor: a new target in antidepressant development?
Młyniec, K., Singewald, N., Holst, Birgitte & Nowak, G., 15 Mar 2015, In: Journal of Affective Disorders. 174, p. 89-100 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Investigation of the GPR39 zinc receptor following inhibition of monoaminergic neurotransmission and potentialization of glutamatergic neurotransmission
Młyniec, K., Gaweł, M., Librowski, T., Reczyński, W., Bystrowska, B. & Holst, Birgitte, Jun 2015, In: Brain Research Bulletin. 115, p. 23-29 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GPR39 (zinc receptor) knockout mice exhibit depression-like behavior and CREB/BDNF down-regulation in the hippocampus
Młyniec, K., Budziszewska, B., Holst, Birgitte, Ostachowicz, B. & Nowak, G., 2015, In: International Journal of Neuropsychopharmacology. 18, 3, p. 1-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Stability, liposome interaction, and in vivo pharmacology of ghrelin in liposomal suspensions
Møller, E. H., Holst, Birgitte, Nielsen, L. H., Pedersen, P. S. & Østergaard, Jesper, 2010, In: Internation Journal of Pharmaceutics. 390, 1, p. 13-18Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved
Møller, C. L., Raun, K., Jacobsen, M. L., Pedersen, T. Å., Holst, Birgitte, Conde-Frieboes, K. W. & Wulff, B. S., 20 Jul 2011, In: Molecular and Cellular Endocrinology. 341, 1-2, p. 9-17 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ghrelin
Mueller, T. D., Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., Batterham, R. L., Benoit, S. C., Bowers, C. Y., Broglio, F., Casanueva, F. F., D'Alessio, D., Depoortere, I., Geliebter, A., Ghigo, E., Cole, P. A., Cowley, M., Cummings, D. E., Dagher, A., Diano, S. & 37 others, , Jun 2015, In: Molecular Metabolism. 4, 6, p. 437-460 24 p.Research output: Contribution to journal › Review › Research › peer-review
ID: 9886
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Dietary non-esterified oleic Acid decreases the jejunal levels of anorectic N-acylethanolamines
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Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity
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PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance
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