The epidermal growth factor precursor in the rat kidney seems to be processed by an aprotinin sensitive proteinase

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Epidermal growth factor (EGF) is synthesized as a membrane bound precursor in the rat kidney. The precursor seems to be processed by an aprotinin sensitive proteinase. Intravenous infusion of aprotinin reduces the urinary excretion of EGF by 85% and increases the amount of renal EGF. Kidney membranes incubated at 37 degrees C release EGF and this release is inhibited by aprotinin.
Original languageEnglish
JournalAgents and actions. Supplements
Volume38 ( Pt 2)
Pages (from-to)183-90
Number of pages8
ISSN0379-0363
Publication statusPublished - 1992

    Research areas

  • Amino Acid Sequence, Animals, Aprotinin, Autoradiography, Cell Membrane, Endopeptidases, Epidermal Growth Factor, Female, Iodine Radioisotopes, Kidney, Male, Microvilli, Protein Precursors, Protein Processing, Post-Translational, Rats, Rats, Wistar, Substrate Specificity

ID: 47487685