Systemic treatment with epidermal growth factor in pigs induces ductal proliferations in the pancreas
Research output: Contribution to journal › Journal article › Research › peer-review
Epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha), and the EGF receptor are often overexpressed in chronic pancreatitis and in malignant pancreatic growth. Transgenic mice overexpressing TGF-alpha develop tissue changes in the pancrease resembling changes found in chronic pancreatitis. The effects of systemic treatment with EGF on the porcine pancrease were investigated in this study.
| Original language | English |
|---|---|
| Journal | Gastroenterology |
| Volume | 113 |
| Issue number | 4 |
| Pages (from-to) | 1367-1374 |
| Number of pages | 8 |
| ISSN | 0016-5085 |
| Publication status | Published - Oct 1997 |
- Animals, Cell Division, Cytoplasmic Granules, Epidermal Growth Factor, Epithelial Cells, Epithelium, Female, Glycoconjugates, Islets of Langerhans, Male, Mice, Mice, Transgenic, Mucins, Pancreatic Ducts, Pancreatic Polypeptide, Proliferating Cell Nuclear Antigen, Somatostatin, Swine, Swine, Miniature
Research areas
ID: 226386