Sonelokimab Interleukin-17A and -F nanobody Treatment of moderate to severe psoriasis Treatment of hidradenitis suppurativa
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Sonelokimab Interleukin-17A and -F nanobody Treatment of moderate to severe psoriasis Treatment of hidradenitis suppurativa. / Yao, Yiqiu; Jorgensen, Astrid-Helene Ravn; Nielsen, Valdemar Wendelboe; Egeberg, Alexander; Thyssen, Jacob P.; Thomsen, Simon Francis.
In: Drugs of the Future, Vol. 47, No. 8, 08.2022, p. 567-573.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Sonelokimab Interleukin-17A and -F nanobody Treatment of moderate to severe psoriasis Treatment of hidradenitis suppurativa
AU - Yao, Yiqiu
AU - Jorgensen, Astrid-Helene Ravn
AU - Nielsen, Valdemar Wendelboe
AU - Egeberg, Alexander
AU - Thyssen, Jacob P.
AU - Thomsen, Simon Francis
PY - 2022/8
Y1 - 2022/8
N2 - Psoriasis is a common, chronic inflammatory disease characterized by sustained inflammation and hyperproliferation of epidermal keratinocytes. With the establishment of the interleukin (IL)-17/IL-23 pathway as a principal player in the etiopathogenesis of psoriasis, and the subsequent development of anti-IL-17/IL-23 biologics, targeted treatment for psoriasis has significantly improved within the past decade. Currently, 4 IL-17 inhibitors are approved for the treatment of moderate to severe plaque psoriasis in adults-secukinumab, ixekizumab, brodalumab and bimekizumab-all of which are monoclonal antibodies. In this scoping review article, we present the current literature on sonelokimab, a novel anti-IL-17A/F nanobody for the treatment of moderate to severe psoriasis.
AB - Psoriasis is a common, chronic inflammatory disease characterized by sustained inflammation and hyperproliferation of epidermal keratinocytes. With the establishment of the interleukin (IL)-17/IL-23 pathway as a principal player in the etiopathogenesis of psoriasis, and the subsequent development of anti-IL-17/IL-23 biologics, targeted treatment for psoriasis has significantly improved within the past decade. Currently, 4 IL-17 inhibitors are approved for the treatment of moderate to severe plaque psoriasis in adults-secukinumab, ixekizumab, brodalumab and bimekizumab-all of which are monoclonal antibodies. In this scoping review article, we present the current literature on sonelokimab, a novel anti-IL-17A/F nanobody for the treatment of moderate to severe psoriasis.
KW - IL-17
KW - Monoclonal antibody
KW - Nanobody
KW - Psoriasis
KW - Sonelokimab
KW - M-1095
KW - SEVERE PLAQUE PSORIASIS
KW - DOUBLE-BLIND
KW - MULTICENTER
KW - EFFICACY
KW - SAFETY
KW - BIMEKIZUMAB
KW - MECHANISMS
KW - FAMILY
KW - SHARK
U2 - 10.1358/dof.2022.47.8.3435135
DO - 10.1358/dof.2022.47.8.3435135
M3 - Journal article
VL - 47
SP - 567
EP - 573
JO - Drugs of the Future
JF - Drugs of the Future
SN - 0377-8282
IS - 8
ER -
ID: 317739663