Pituitary mammosomatotroph adenomas develop in old mice transgenic for growth hormone-releasing hormone
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Pituitary mammosomatotroph adenomas develop in old mice transgenic for growth hormone-releasing hormone. / Asa, S L; Kovacs, K; Stefaneanu, L; Horvath, E; Billestrup, Nils; Gonzalez-Manchon, C; Vale, W.
In: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), Vol. 193, No. 3, 03.1990, p. 232-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Pituitary mammosomatotroph adenomas develop in old mice transgenic for growth hormone-releasing hormone
AU - Asa, S L
AU - Kovacs, K
AU - Stefaneanu, L
AU - Horvath, E
AU - Billestrup, Nils
AU - Gonzalez-Manchon, C
AU - Vale, W
PY - 1990/3
Y1 - 1990/3
N2 - It has been shown that mice transgenic for human growth hormone-releasing hormone (GRH) develop hyperplasia of pituitary somatotrophs and mammosomatotrophs, cells capable of producing both growth hormone and prolactin, by 8 months of age. We now report for the first time that old GRH-transgenic mice, 16 to 24 months of age, develop pituitary mammosomatotroph adenomas. These findings provide conclusive evidence that protracted stimulation of secretory activity can cause proliferation, hyperplasia and adenoma of adenohypophysial cells.
AB - It has been shown that mice transgenic for human growth hormone-releasing hormone (GRH) develop hyperplasia of pituitary somatotrophs and mammosomatotrophs, cells capable of producing both growth hormone and prolactin, by 8 months of age. We now report for the first time that old GRH-transgenic mice, 16 to 24 months of age, develop pituitary mammosomatotroph adenomas. These findings provide conclusive evidence that protracted stimulation of secretory activity can cause proliferation, hyperplasia and adenoma of adenohypophysial cells.
KW - Adenoma
KW - Aging
KW - Animals
KW - Growth Hormone
KW - Growth Hormone-Releasing Hormone
KW - Humans
KW - Hyperplasia
KW - Mice
KW - Mice, Transgenic
KW - Pituitary Gland
KW - Pituitary Neoplasms
KW - Prolactin
M3 - Journal article
C2 - 2106141
VL - 193
SP - 232
EP - 235
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
SN - 0037-9727
IS - 3
ER -
ID: 132900636