Effect of antisecretory agents and vagotomy on healing of "chronic" cysteamine-induced duodenal ulcers in rats

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Effect of antisecretory agents and vagotomy on healing of "chronic" cysteamine-induced duodenal ulcers in rats. / Poulsen, Steen Seier.

In: Digestive Diseases and Sciences, Vol. 31, No. 7, 07.1986, p. 753-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Poulsen, SS 1986, 'Effect of antisecretory agents and vagotomy on healing of "chronic" cysteamine-induced duodenal ulcers in rats', Digestive Diseases and Sciences, vol. 31, no. 7, pp. 753-9.

APA

Poulsen, S. S. (1986). Effect of antisecretory agents and vagotomy on healing of "chronic" cysteamine-induced duodenal ulcers in rats. Digestive Diseases and Sciences, 31(7), 753-9.

Vancouver

Poulsen SS. Effect of antisecretory agents and vagotomy on healing of "chronic" cysteamine-induced duodenal ulcers in rats. Digestive Diseases and Sciences. 1986 Jul;31(7):753-9.

Author

Poulsen, Steen Seier. / Effect of antisecretory agents and vagotomy on healing of "chronic" cysteamine-induced duodenal ulcers in rats. In: Digestive Diseases and Sciences. 1986 ; Vol. 31, No. 7. pp. 753-9.

Bibtex

@article{84bb200974a448aabd078dd672d2ed00,
title = "Effect of antisecretory agents and vagotomy on healing of {"}chronic{"} cysteamine-induced duodenal ulcers in rats",
abstract = "Penetrated cysteamine-induced duodenal ulcers in rats have a very prolonged course of healing. In this study, it was investigated how much the healing of these ulcers is accelerated by some treatments. The treatments included omeprazole, cimetidine, and truncal vagotomy. In addition, the effect of omeprazole and cimetidine on gastric acid secretion was investigated in chronic gastric fistula rats. After 25 days of treatment, significantly more rats in the treated groups had healed ulcers than in the control group. There was little further improvement up to 100 days of treatment, and the difference between treated and untreated groups decreased. The morphology of healing ulcers in treated and untreated rats was also compared. In controls, there was a simultaneous regeneration of mucosa and the submucosal Brunner's glands from the edges of the ulcer, the slow proliferation rate of the latter probably being decisive for the prolonged healing. In the treated rats, the mucosa first regenerated with formation of crypts and low villi and subsequently, the Brunner's glands were formed by proliferation from the bottom of the crypts.",
keywords = "Animals, Anti-Ulcer Agents, Benzimidazoles, Brunner Glands, Chronic Disease, Cimetidine, Cysteamine, Duodenal Ulcer, Female, Gastric Acid, Intestinal Mucosa, Omeprazole, Rats, Rats, Inbred Strains, Vagotomy",
author = "Poulsen, {Steen Seier}",
year = "1986",
month = jul,
language = "English",
volume = "31",
pages = "753--9",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer",
number = "7",

}

RIS

TY - JOUR

T1 - Effect of antisecretory agents and vagotomy on healing of "chronic" cysteamine-induced duodenal ulcers in rats

AU - Poulsen, Steen Seier

PY - 1986/7

Y1 - 1986/7

N2 - Penetrated cysteamine-induced duodenal ulcers in rats have a very prolonged course of healing. In this study, it was investigated how much the healing of these ulcers is accelerated by some treatments. The treatments included omeprazole, cimetidine, and truncal vagotomy. In addition, the effect of omeprazole and cimetidine on gastric acid secretion was investigated in chronic gastric fistula rats. After 25 days of treatment, significantly more rats in the treated groups had healed ulcers than in the control group. There was little further improvement up to 100 days of treatment, and the difference between treated and untreated groups decreased. The morphology of healing ulcers in treated and untreated rats was also compared. In controls, there was a simultaneous regeneration of mucosa and the submucosal Brunner's glands from the edges of the ulcer, the slow proliferation rate of the latter probably being decisive for the prolonged healing. In the treated rats, the mucosa first regenerated with formation of crypts and low villi and subsequently, the Brunner's glands were formed by proliferation from the bottom of the crypts.

AB - Penetrated cysteamine-induced duodenal ulcers in rats have a very prolonged course of healing. In this study, it was investigated how much the healing of these ulcers is accelerated by some treatments. The treatments included omeprazole, cimetidine, and truncal vagotomy. In addition, the effect of omeprazole and cimetidine on gastric acid secretion was investigated in chronic gastric fistula rats. After 25 days of treatment, significantly more rats in the treated groups had healed ulcers than in the control group. There was little further improvement up to 100 days of treatment, and the difference between treated and untreated groups decreased. The morphology of healing ulcers in treated and untreated rats was also compared. In controls, there was a simultaneous regeneration of mucosa and the submucosal Brunner's glands from the edges of the ulcer, the slow proliferation rate of the latter probably being decisive for the prolonged healing. In the treated rats, the mucosa first regenerated with formation of crypts and low villi and subsequently, the Brunner's glands were formed by proliferation from the bottom of the crypts.

KW - Animals

KW - Anti-Ulcer Agents

KW - Benzimidazoles

KW - Brunner Glands

KW - Chronic Disease

KW - Cimetidine

KW - Cysteamine

KW - Duodenal Ulcer

KW - Female

KW - Gastric Acid

KW - Intestinal Mucosa

KW - Omeprazole

KW - Rats

KW - Rats, Inbred Strains

KW - Vagotomy

M3 - Journal article

C2 - 3720471

VL - 31

SP - 753

EP - 759

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 7

ER -

ID: 47488918