Clinical and hormonal effects of two contraceptives: Correlation to serum concentrations of levonorgestrel and gestodene

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Clinical and hormonal effects of two contraceptives : Correlation to serum concentrations of levonorgestrel and gestodene. / Refn, H.; Kjær, A.; Lebech, A. M.; Borggaard, B.; Schierup, L.

In: Contraception, Vol. 41, No. 3, 03.1990, p. 259-269.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Refn, H, Kjær, A, Lebech, AM, Borggaard, B & Schierup, L 1990, 'Clinical and hormonal effects of two contraceptives: Correlation to serum concentrations of levonorgestrel and gestodene', Contraception, vol. 41, no. 3, pp. 259-269. https://doi.org/10.1016/0010-7824(90)90067-6

APA

Refn, H., Kjær, A., Lebech, A. M., Borggaard, B., & Schierup, L. (1990). Clinical and hormonal effects of two contraceptives: Correlation to serum concentrations of levonorgestrel and gestodene. Contraception, 41(3), 259-269. https://doi.org/10.1016/0010-7824(90)90067-6

Vancouver

Refn H, Kjær A, Lebech AM, Borggaard B, Schierup L. Clinical and hormonal effects of two contraceptives: Correlation to serum concentrations of levonorgestrel and gestodene. Contraception. 1990 Mar;41(3):259-269. https://doi.org/10.1016/0010-7824(90)90067-6

Author

Refn, H. ; Kjær, A. ; Lebech, A. M. ; Borggaard, B. ; Schierup, L. / Clinical and hormonal effects of two contraceptives : Correlation to serum concentrations of levonorgestrel and gestodene. In: Contraception. 1990 ; Vol. 41, No. 3. pp. 259-269.

Bibtex

@article{8ee3e166b58746af889b4cd881ee90f0,
title = "Clinical and hormonal effects of two contraceptives: Correlation to serum concentrations of levonorgestrel and gestodene",
abstract = "Two triphasic oral contraceptives containing gestodene (GES) (a new progestogen) and levonorgestrel (LNG) were compared with respect to contraceptive effect, cycle control, acceptability and side effects. The serum concentrations of ingested hormones were measured together with ovarian, pituitary, and some adrenal hormones, as well as sex hormone binding globulin (SHBG). The contraceptive effect and cycle control were good with both preparations, and there were only a few minor side effects. SHBG was elevated 2-fold in the LNG group and 3-fold in the GES group. The GES concentration in serum varied more than the LNG concentration, but with correction for variations in SHBG binding, less variability in actual GES and LNG concentrations was seen. Serum levels of FSH, LH, estradiol and progesterone were all depressed with both preparations. The depression was more marked in the GES group, despite lower progestogen ingestion and similar serum concentrations. Equal decreases were found in testosterone, androstenedione and dehydroepiandrosterone sulfate (DHEA-S) with both preparations.",
author = "H. Refn and A. Kj{\ae}r and Lebech, {A. M.} and B. Borggaard and L. Schierup",
year = "1990",
month = mar,
doi = "10.1016/0010-7824(90)90067-6",
language = "English",
volume = "41",
pages = "259--269",
journal = "Contraception",
issn = "0010-7824",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Clinical and hormonal effects of two contraceptives

T2 - Correlation to serum concentrations of levonorgestrel and gestodene

AU - Refn, H.

AU - Kjær, A.

AU - Lebech, A. M.

AU - Borggaard, B.

AU - Schierup, L.

PY - 1990/3

Y1 - 1990/3

N2 - Two triphasic oral contraceptives containing gestodene (GES) (a new progestogen) and levonorgestrel (LNG) were compared with respect to contraceptive effect, cycle control, acceptability and side effects. The serum concentrations of ingested hormones were measured together with ovarian, pituitary, and some adrenal hormones, as well as sex hormone binding globulin (SHBG). The contraceptive effect and cycle control were good with both preparations, and there were only a few minor side effects. SHBG was elevated 2-fold in the LNG group and 3-fold in the GES group. The GES concentration in serum varied more than the LNG concentration, but with correction for variations in SHBG binding, less variability in actual GES and LNG concentrations was seen. Serum levels of FSH, LH, estradiol and progesterone were all depressed with both preparations. The depression was more marked in the GES group, despite lower progestogen ingestion and similar serum concentrations. Equal decreases were found in testosterone, androstenedione and dehydroepiandrosterone sulfate (DHEA-S) with both preparations.

AB - Two triphasic oral contraceptives containing gestodene (GES) (a new progestogen) and levonorgestrel (LNG) were compared with respect to contraceptive effect, cycle control, acceptability and side effects. The serum concentrations of ingested hormones were measured together with ovarian, pituitary, and some adrenal hormones, as well as sex hormone binding globulin (SHBG). The contraceptive effect and cycle control were good with both preparations, and there were only a few minor side effects. SHBG was elevated 2-fold in the LNG group and 3-fold in the GES group. The GES concentration in serum varied more than the LNG concentration, but with correction for variations in SHBG binding, less variability in actual GES and LNG concentrations was seen. Serum levels of FSH, LH, estradiol and progesterone were all depressed with both preparations. The depression was more marked in the GES group, despite lower progestogen ingestion and similar serum concentrations. Equal decreases were found in testosterone, androstenedione and dehydroepiandrosterone sulfate (DHEA-S) with both preparations.

UR - http://www.scopus.com/inward/record.url?scp=0025230441&partnerID=8YFLogxK

U2 - 10.1016/0010-7824(90)90067-6

DO - 10.1016/0010-7824(90)90067-6

M3 - Journal article

C2 - 2138974

AN - SCOPUS:0025230441

VL - 41

SP - 259

EP - 269

JO - Contraception

JF - Contraception

SN - 0010-7824

IS - 3

ER -

ID: 283517321