Anti-arrhythmic investigations in large animal models of atrial fibrillation
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Anti-arrhythmic investigations in large animal models of atrial fibrillation. / Saljic, Arnela; Jespersen, Thomas; Buhl, Rikke.
In: British Journal of Pharmacology, Vol. 179, No. 5, 2022, p. 838-858.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Anti-arrhythmic investigations in large animal models of atrial fibrillation
AU - Saljic, Arnela
AU - Jespersen, Thomas
AU - Buhl, Rikke
N1 - Publisher Copyright: © 2021 The British Pharmacological Society
PY - 2022
Y1 - 2022
N2 - Atrial fibrillation (AF) constitutes an increasing health problem in the aging population. Animal models reflecting human phenotypes are needed to understand the mechanisms of AF, as well as to test new pharmacological interventions. In recent years, a number of large animal models, primarily pigs, goats, dog and horses have been used in AF research. These animals can to a certain extent recapitulate the human pathophysiological characteristics and serve as valuable tools in investigating new pharmacological interventions for treating AF. This review focuses on anti-arrhythmic investigations in large animals. Initially, spontaneous AF in small and large mammals is discussed. This is followed by a short presentation of frequently used methods for inducing short- and long-term AF. The major focus of the review is on anti-arrhythmic compounds either frequently used in the human clinic (ranolazine, flecainide, vernakalant and amiodarone) or being promising new AF medicine candidates (IK,Ach, ISK,Ca and IK2P blockers).
AB - Atrial fibrillation (AF) constitutes an increasing health problem in the aging population. Animal models reflecting human phenotypes are needed to understand the mechanisms of AF, as well as to test new pharmacological interventions. In recent years, a number of large animal models, primarily pigs, goats, dog and horses have been used in AF research. These animals can to a certain extent recapitulate the human pathophysiological characteristics and serve as valuable tools in investigating new pharmacological interventions for treating AF. This review focuses on anti-arrhythmic investigations in large animals. Initially, spontaneous AF in small and large mammals is discussed. This is followed by a short presentation of frequently used methods for inducing short- and long-term AF. The major focus of the review is on anti-arrhythmic compounds either frequently used in the human clinic (ranolazine, flecainide, vernakalant and amiodarone) or being promising new AF medicine candidates (IK,Ach, ISK,Ca and IK2P blockers).
KW - Antiarrhythmic drugs
KW - atrial fibrillation
KW - ion channels
KW - pharmacology
U2 - 10.1111/bph.15417
DO - 10.1111/bph.15417
M3 - Review
C2 - 33624840
AN - SCOPUS:85104049783
VL - 179
SP - 838
EP - 858
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
SN - 0007-1188
IS - 5
ER -
ID: 262800856