(68)Ga-DOTATOC PET and gene expression profile in patients with neuroendocrine carcinomas: strong correlation between PET tracer uptake and gene expression of somatostatin receptor subtype 2

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Standard

(68)Ga-DOTATOC PET and gene expression profile in patients with neuroendocrine carcinomas : strong correlation between PET tracer uptake and gene expression of somatostatin receptor subtype 2. / Olsen, Ingrid H; Langer, Seppo W; Federspiel, Birgitte H; Oxbøl, Jytte; Loft, Annika; Berthelsen, Anne Kiil; Mortensen, Jann; Oturai, Peter; Knigge, Ulrich; Kjær, Andreas.

In: American Journal of Nuclear Medicine and Molecular Imaging, Vol. 6, No. 1, 2016, p. 59-72.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Olsen, IH, Langer, SW, Federspiel, BH, Oxbøl, J, Loft, A, Berthelsen, AK, Mortensen, J, Oturai, P, Knigge, U & Kjær, A 2016, '(68)Ga-DOTATOC PET and gene expression profile in patients with neuroendocrine carcinomas: strong correlation between PET tracer uptake and gene expression of somatostatin receptor subtype 2', American Journal of Nuclear Medicine and Molecular Imaging, vol. 6, no. 1, pp. 59-72. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749505/pdf/ajnmmi0006-0059.pdf>

APA

Olsen, I. H., Langer, S. W., Federspiel, B. H., Oxbøl, J., Loft, A., Berthelsen, A. K., Mortensen, J., Oturai, P., Knigge, U., & Kjær, A. (2016). (68)Ga-DOTATOC PET and gene expression profile in patients with neuroendocrine carcinomas: strong correlation between PET tracer uptake and gene expression of somatostatin receptor subtype 2. American Journal of Nuclear Medicine and Molecular Imaging, 6(1), 59-72. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749505/pdf/ajnmmi0006-0059.pdf

Vancouver

Olsen IH, Langer SW, Federspiel BH, Oxbøl J, Loft A, Berthelsen AK et al. (68)Ga-DOTATOC PET and gene expression profile in patients with neuroendocrine carcinomas: strong correlation between PET tracer uptake and gene expression of somatostatin receptor subtype 2. American Journal of Nuclear Medicine and Molecular Imaging. 2016;6(1):59-72.

Author

Olsen, Ingrid H ; Langer, Seppo W ; Federspiel, Birgitte H ; Oxbøl, Jytte ; Loft, Annika ; Berthelsen, Anne Kiil ; Mortensen, Jann ; Oturai, Peter ; Knigge, Ulrich ; Kjær, Andreas. / (68)Ga-DOTATOC PET and gene expression profile in patients with neuroendocrine carcinomas : strong correlation between PET tracer uptake and gene expression of somatostatin receptor subtype 2. In: American Journal of Nuclear Medicine and Molecular Imaging. 2016 ; Vol. 6, No. 1. pp. 59-72.

Bibtex

@article{28bd47fb407d4030901dd9005333ea5a,
title = "(68)Ga-DOTATOC PET and gene expression profile in patients with neuroendocrine carcinomas: strong correlation between PET tracer uptake and gene expression of somatostatin receptor subtype 2",
abstract = "Somatostatin receptor expression on both protein and gene expression level was compared with in vivo (68)Ga-DOTATOC PET/CT in patients with neuroendocrine carcinomas (NEC). Twenty-one patients with verified NEC who underwent a (68)Ga-DOTATOC PET/CT between November 2012 and May 2014, were retrospectively included. By real-time polymerase chain reaction, we quantitatively determined the gene expression of several genes and compared with (68)Ga-DOTATOC PET uptake. By immunohistochemistry we qualitatively studied the expression of assorted proteins in NEC. The median age at diagnosis was 68 years (range 41-84) years. All patients had WHO performance status 0-1. Median Ki67 index was 50% (range 20-100%). Gene expression of somatostatin receptor subtype (SSTR) 2 and Ki67 were both positively correlated to the (68)Ga-DOTATOC uptake (r=0.89; p<0.0001 and r=0.5; p=0.021, respectively). Furthermore, SSTR2 and SSTR5 gene expression were strongly and positively correlated (r=0.57; p=0.006). This study as the first verifies a positive and close correlation of (68)Ga-DOTATOC uptake and gene expression of SSTR2 in NEC. SSTR2 gene expression has a stronger correlation to (68)Ga-DOTATOC uptake than SSTR5. In addition, the results indicate that the gene expression levels of SSTR2 and SSTR5 at large follow one another.",
author = "Olsen, {Ingrid H} and Langer, {Seppo W} and Federspiel, {Birgitte H} and Jytte Oxb{\o}l and Annika Loft and Berthelsen, {Anne Kiil} and Jann Mortensen and Peter Oturai and Ulrich Knigge and Andreas Kj{\ae}r",
year = "2016",
language = "English",
volume = "6",
pages = "59--72",
journal = "American Journal of Nuclear Medicine and Molecular Imaging",
issn = "2160-8407",
publisher = "e-Century Publishing Corporation",
number = "1",

}

RIS

TY - JOUR

T1 - (68)Ga-DOTATOC PET and gene expression profile in patients with neuroendocrine carcinomas

T2 - strong correlation between PET tracer uptake and gene expression of somatostatin receptor subtype 2

AU - Olsen, Ingrid H

AU - Langer, Seppo W

AU - Federspiel, Birgitte H

AU - Oxbøl, Jytte

AU - Loft, Annika

AU - Berthelsen, Anne Kiil

AU - Mortensen, Jann

AU - Oturai, Peter

AU - Knigge, Ulrich

AU - Kjær, Andreas

PY - 2016

Y1 - 2016

N2 - Somatostatin receptor expression on both protein and gene expression level was compared with in vivo (68)Ga-DOTATOC PET/CT in patients with neuroendocrine carcinomas (NEC). Twenty-one patients with verified NEC who underwent a (68)Ga-DOTATOC PET/CT between November 2012 and May 2014, were retrospectively included. By real-time polymerase chain reaction, we quantitatively determined the gene expression of several genes and compared with (68)Ga-DOTATOC PET uptake. By immunohistochemistry we qualitatively studied the expression of assorted proteins in NEC. The median age at diagnosis was 68 years (range 41-84) years. All patients had WHO performance status 0-1. Median Ki67 index was 50% (range 20-100%). Gene expression of somatostatin receptor subtype (SSTR) 2 and Ki67 were both positively correlated to the (68)Ga-DOTATOC uptake (r=0.89; p<0.0001 and r=0.5; p=0.021, respectively). Furthermore, SSTR2 and SSTR5 gene expression were strongly and positively correlated (r=0.57; p=0.006). This study as the first verifies a positive and close correlation of (68)Ga-DOTATOC uptake and gene expression of SSTR2 in NEC. SSTR2 gene expression has a stronger correlation to (68)Ga-DOTATOC uptake than SSTR5. In addition, the results indicate that the gene expression levels of SSTR2 and SSTR5 at large follow one another.

AB - Somatostatin receptor expression on both protein and gene expression level was compared with in vivo (68)Ga-DOTATOC PET/CT in patients with neuroendocrine carcinomas (NEC). Twenty-one patients with verified NEC who underwent a (68)Ga-DOTATOC PET/CT between November 2012 and May 2014, were retrospectively included. By real-time polymerase chain reaction, we quantitatively determined the gene expression of several genes and compared with (68)Ga-DOTATOC PET uptake. By immunohistochemistry we qualitatively studied the expression of assorted proteins in NEC. The median age at diagnosis was 68 years (range 41-84) years. All patients had WHO performance status 0-1. Median Ki67 index was 50% (range 20-100%). Gene expression of somatostatin receptor subtype (SSTR) 2 and Ki67 were both positively correlated to the (68)Ga-DOTATOC uptake (r=0.89; p<0.0001 and r=0.5; p=0.021, respectively). Furthermore, SSTR2 and SSTR5 gene expression were strongly and positively correlated (r=0.57; p=0.006). This study as the first verifies a positive and close correlation of (68)Ga-DOTATOC uptake and gene expression of SSTR2 in NEC. SSTR2 gene expression has a stronger correlation to (68)Ga-DOTATOC uptake than SSTR5. In addition, the results indicate that the gene expression levels of SSTR2 and SSTR5 at large follow one another.

M3 - Journal article

C2 - 27069766

VL - 6

SP - 59

EP - 72

JO - American Journal of Nuclear Medicine and Molecular Imaging

JF - American Journal of Nuclear Medicine and Molecular Imaging

SN - 2160-8407

IS - 1

ER -

ID: 173810127