Biomedicinsk Institut > Ansatte
Anna Lindeløv Vestergaard
Afd. for Endokrinologisk Forskning
Blegdamsvej 3, 2200 København N, 12.6, Bygning: 08
I graduated as M.Sc. in 2008 and obtained my PhD in Molecular and Human Biology from Department of Molecular Biology at Aarhus University in 2010. My PhD was based on studies of the involvement of type I interferons in endometriosis. My efforts included research stays at The Diamentina Institute, Brisbane, Australia, and The Danish Cancer Society, Copenhagen, and resulted in three first-authored peer-reviewed publications. In my first post doc, I investigated the enzymatic mechanism of phospholipid flippases at Department of Biomedicine, Aarhus University, and Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland, resulting in so far two high-impact papers in Proceedings of the National Academy of Sciences USA (PNAS). Since October 2014, I have taken up diabetes research as postdoc in the Immuno-Endocrinology lab, University of Copenhagen, where I focus on beta-cell microRNAs in diabetes.
Diabetes and its late complications are incurable grand health challenges of the century, and inflammatory beta-cell failure contributes to type 1 and type 2 diabetes pathogenesis. We know that histone deacetylase inhibitors (HDACi) prevent beta-cell failure and apoptosis induced by pro-inflammatory cytokines in vitro and in vivo, but the mechanisms are unclear. My research aims to determine if the mechanism involves upregulation of microRNAs that repress the translation of proteins responsible for beta-cell oxidative stress and death to find new therapeutic targets.