Biomedicinsk Institut > Ansatte
Seyed Mojtaba Ghiasi
Afd. for Endokrinologisk Forskning
Blegdamsvej 3, 2200 København N, 12.6, Bygning: 06
My research in the lab of Prof. Thomas Mandrup-Poulsen focuses on the role of RNA oxidation and nitration in β-cell failure and understanding if metabolic and inflammatory oxidative stress causes damage to central β-cell RNAs regulating insulin biosynthesis, processing and secretion, and if prevention of such damage reverts β-cell secretory dysfunction induced by metabolic and inflammatory oxidative stress in vitro and in vivo. Trials of drugs targeting the extremely short-lived oxidative radicals have failed in many diseases probably due to inappropriate pharmaco-kinetics and -dynamics. Therefore the perspective would be to prevent oxidative tissue dysfunction by intercepting the down-stream actions of these radicals on cellular RNA.