Interstitial concentrations of adipokines in subcutaneous abdominal and femoral adipose tissue

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Standard

Interstitial concentrations of adipokines in subcutaneous abdominal and femoral adipose tissue. / Nielsen, Ninna Bo; Højbjerre, Lise; Sonne, Mette P; Alibegovic, Amra C; Vaag, Allan; Dela, Flemming; Stallknecht, Bente.

I: Regulatory Peptides, Bind 155, Nr. 1-3, 2009, s. 39-45.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Nielsen, NB, Højbjerre, L, Sonne, MP, Alibegovic, AC, Vaag, A, Dela, F & Stallknecht, B 2009, 'Interstitial concentrations of adipokines in subcutaneous abdominal and femoral adipose tissue', Regulatory Peptides, bind 155, nr. 1-3, s. 39-45. https://doi.org/10.1016/j.regpep.2009.04.010

APA

Nielsen, N. B., Højbjerre, L., Sonne, M. P., Alibegovic, A. C., Vaag, A., Dela, F., & Stallknecht, B. (2009). Interstitial concentrations of adipokines in subcutaneous abdominal and femoral adipose tissue. Regulatory Peptides, 155(1-3), 39-45. https://doi.org/10.1016/j.regpep.2009.04.010

Vancouver

Nielsen NB, Højbjerre L, Sonne MP, Alibegovic AC, Vaag A, Dela F o.a. Interstitial concentrations of adipokines in subcutaneous abdominal and femoral adipose tissue. Regulatory Peptides. 2009;155(1-3):39-45. https://doi.org/10.1016/j.regpep.2009.04.010

Author

Nielsen, Ninna Bo ; Højbjerre, Lise ; Sonne, Mette P ; Alibegovic, Amra C ; Vaag, Allan ; Dela, Flemming ; Stallknecht, Bente. / Interstitial concentrations of adipokines in subcutaneous abdominal and femoral adipose tissue. I: Regulatory Peptides. 2009 ; Bind 155, Nr. 1-3. s. 39-45.

Bibtex

@article{9c72b8505f2b11dea8de000ea68e967b,
title = "Interstitial concentrations of adipokines in subcutaneous abdominal and femoral adipose tissue",
abstract = "Adipokines play important regulatory roles in the pathophysiology of obesity and insulin resistance. We measured plasma and interstitial concentrations of the adipokines adiponectin, resistin, leptin, monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6) and interleukin-8 (IL-8) in subcutaneous, abdominal and femoral adipose tissue using calibrated, large-pore microdialysis technique in 8 healthy, lean men on 2 experimental days. The interstitial leptin concentration was 2.5-fold higher in subcutaneous, femoral than abdominal adipose tissue (P<0.05), but no regional differences were found for the remaining adipokines (P>0.05). Adiponectin and leptin concentrations were higher in plasma than subcutaneous adipose tissue (approximately 25-fold and approximately 2-fold, respectively, P<0.05), whereas MCP-1, IL-6 and IL-8 concentrations were higher in subcutaneous adipose tissue than plasma (approximately 100-fold, approximately 200-fold and approximately 1000-fold, respectively, P<0.05). Resistin concentrations did not differ significantly between compartments. Adipose tissue blood flow (ATBF) showed no regional difference (P>0.05). The intra- and inter-subject variations of all investigated adipokines as well as of ATBF were substantial (coefficient of variation: 4-177%). In conclusion, interstitial leptin concentrations are approximately 2.5-fold higher in subcutaneous, femoral than abdominal adipose tissue, which might be a potential mechanism behind the health-benefits of {"}pear-shape{"}. Furthermore, subcutaneous adipose tissue has a marked production of pro-inflammatory adipokines.",
author = "Nielsen, {Ninna Bo} and Lise H{\o}jbjerre and Sonne, {Mette P} and Alibegovic, {Amra C} and Allan Vaag and Flemming Dela and Bente Stallknecht",
year = "2009",
doi = "10.1016/j.regpep.2009.04.010",
language = "English",
volume = "155",
pages = "39--45",
journal = "Regulatory Peptides",
issn = "0167-0115",
publisher = "Elsevier",
number = "1-3",

}

RIS

TY - JOUR

T1 - Interstitial concentrations of adipokines in subcutaneous abdominal and femoral adipose tissue

AU - Nielsen, Ninna Bo

AU - Højbjerre, Lise

AU - Sonne, Mette P

AU - Alibegovic, Amra C

AU - Vaag, Allan

AU - Dela, Flemming

AU - Stallknecht, Bente

PY - 2009

Y1 - 2009

N2 - Adipokines play important regulatory roles in the pathophysiology of obesity and insulin resistance. We measured plasma and interstitial concentrations of the adipokines adiponectin, resistin, leptin, monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6) and interleukin-8 (IL-8) in subcutaneous, abdominal and femoral adipose tissue using calibrated, large-pore microdialysis technique in 8 healthy, lean men on 2 experimental days. The interstitial leptin concentration was 2.5-fold higher in subcutaneous, femoral than abdominal adipose tissue (P<0.05), but no regional differences were found for the remaining adipokines (P>0.05). Adiponectin and leptin concentrations were higher in plasma than subcutaneous adipose tissue (approximately 25-fold and approximately 2-fold, respectively, P<0.05), whereas MCP-1, IL-6 and IL-8 concentrations were higher in subcutaneous adipose tissue than plasma (approximately 100-fold, approximately 200-fold and approximately 1000-fold, respectively, P<0.05). Resistin concentrations did not differ significantly between compartments. Adipose tissue blood flow (ATBF) showed no regional difference (P>0.05). The intra- and inter-subject variations of all investigated adipokines as well as of ATBF were substantial (coefficient of variation: 4-177%). In conclusion, interstitial leptin concentrations are approximately 2.5-fold higher in subcutaneous, femoral than abdominal adipose tissue, which might be a potential mechanism behind the health-benefits of "pear-shape". Furthermore, subcutaneous adipose tissue has a marked production of pro-inflammatory adipokines.

AB - Adipokines play important regulatory roles in the pathophysiology of obesity and insulin resistance. We measured plasma and interstitial concentrations of the adipokines adiponectin, resistin, leptin, monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6) and interleukin-8 (IL-8) in subcutaneous, abdominal and femoral adipose tissue using calibrated, large-pore microdialysis technique in 8 healthy, lean men on 2 experimental days. The interstitial leptin concentration was 2.5-fold higher in subcutaneous, femoral than abdominal adipose tissue (P<0.05), but no regional differences were found for the remaining adipokines (P>0.05). Adiponectin and leptin concentrations were higher in plasma than subcutaneous adipose tissue (approximately 25-fold and approximately 2-fold, respectively, P<0.05), whereas MCP-1, IL-6 and IL-8 concentrations were higher in subcutaneous adipose tissue than plasma (approximately 100-fold, approximately 200-fold and approximately 1000-fold, respectively, P<0.05). Resistin concentrations did not differ significantly between compartments. Adipose tissue blood flow (ATBF) showed no regional difference (P>0.05). The intra- and inter-subject variations of all investigated adipokines as well as of ATBF were substantial (coefficient of variation: 4-177%). In conclusion, interstitial leptin concentrations are approximately 2.5-fold higher in subcutaneous, femoral than abdominal adipose tissue, which might be a potential mechanism behind the health-benefits of "pear-shape". Furthermore, subcutaneous adipose tissue has a marked production of pro-inflammatory adipokines.

U2 - 10.1016/j.regpep.2009.04.010

DO - 10.1016/j.regpep.2009.04.010

M3 - Journal article

C2 - 19376162

VL - 155

SP - 39

EP - 45

JO - Regulatory Peptides

JF - Regulatory Peptides

SN - 0167-0115

IS - 1-3

ER -

ID: 12771764