Fully Automated, Fast Motion Correction of Dynamic Whole-Body and Total-Body PET/CT Imaging Studies
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Fully Automated, Fast Motion Correction of Dynamic Whole-Body and Total-Body PET/CT Imaging Studies. / Sundar, Lalith Kumar Shiyam; Lassen, Martin Lyngby; Gutschmayer, Sebastian; Ferrara, Daria; Calabrò, Anna; Yu, Josef; Kluge, Kilian; Wang, Yiran; Nardo, Lorenzo; Hasbak, Philip; Kjaer, Andreas; Abdelhafez, Yasser G.; Wang, Guobao; Cherry, Simon R.; Spencer, Benjamin A.; Badawi, Ramsey D.; Beyer, Thomas; Muzik, Otto.
I: Journal of Nuclear Medicine, Bind 64, Nr. 7, 2023, s. 1145-1153.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Fully Automated, Fast Motion Correction of Dynamic Whole-Body and Total-Body PET/CT Imaging Studies
AU - Sundar, Lalith Kumar Shiyam
AU - Lassen, Martin Lyngby
AU - Gutschmayer, Sebastian
AU - Ferrara, Daria
AU - Calabrò, Anna
AU - Yu, Josef
AU - Kluge, Kilian
AU - Wang, Yiran
AU - Nardo, Lorenzo
AU - Hasbak, Philip
AU - Kjaer, Andreas
AU - Abdelhafez, Yasser G.
AU - Wang, Guobao
AU - Cherry, Simon R.
AU - Spencer, Benjamin A.
AU - Badawi, Ramsey D.
AU - Beyer, Thomas
AU - Muzik, Otto
N1 - Publisher Copyright: Copyright © 2023 by the Society of Nuclear Medicine and Molecular Imaging.
PY - 2023
Y1 - 2023
N2 - We introduce the Fast Algorithm for Motion Correction (FALCON) software, which allows correction of both rigid and nonlinear motion artifacts in dynamic whole-body (WB) images, irrespective of the PET/CT system or the tracer. Methods: Motion was corrected using affine alignment followed by a diffeomorphic approach to account for nonrigid deformations. In both steps, images were registered using multiscale image alignment. Moreover, the frames suited to successful motion correction were automatically estimated by calculating the initial normalized cross-correlation metric between the reference frame and the other moving frames. To evaluate motion correction performance, WB dynamic image sequences from 3 different PET/CT systems (Biograph mCT, Biograph Vision 600, and uEXPLORER) using 6 different tracers (18F-FDG, 18F-fluciclovine, 68Ga-PSMA, 68Ga-DOTA-TATE, 11C-Pittsburgh compound B, and 82Rb) were considered. Motion correction accuracy was assessed using 4 different measures: change in volume mismatch between individual WB image volumes to assess gross body motion, change in displacement of a large organ (liver dome) within the torso due to respiration, change in intensity in small tumor nodules due to motion blur, and constancy of activity concentration levels. Results: Motion correction decreased gross body motion artifacts and reduced volume mismatch across dynamic frames by about 50%. Moreover, large-organ motion correction was assessed on the basis of correction of liver dome motion, which was removed entirely in about 70% of all cases. Motion correction also improved tumor intensity, resulting in an average increase in tumor SUVs by 15%. Large deformations seen in gated cardiac 82Rb images were managed without leading to anomalous distortions or substantial intensity changes in the resulting images. Finally, the constancy of activity concentration levels was reasonably preserved (,2% change) in large organs before and after motion correction. Conclusion: FALCON allows fast and accurate correction of rigid and nonrigid WB motion artifacts while being insensitive to scanner hardware or tracer distribution, making it applicable to a wide range of PET imaging scenarios.
AB - We introduce the Fast Algorithm for Motion Correction (FALCON) software, which allows correction of both rigid and nonlinear motion artifacts in dynamic whole-body (WB) images, irrespective of the PET/CT system or the tracer. Methods: Motion was corrected using affine alignment followed by a diffeomorphic approach to account for nonrigid deformations. In both steps, images were registered using multiscale image alignment. Moreover, the frames suited to successful motion correction were automatically estimated by calculating the initial normalized cross-correlation metric between the reference frame and the other moving frames. To evaluate motion correction performance, WB dynamic image sequences from 3 different PET/CT systems (Biograph mCT, Biograph Vision 600, and uEXPLORER) using 6 different tracers (18F-FDG, 18F-fluciclovine, 68Ga-PSMA, 68Ga-DOTA-TATE, 11C-Pittsburgh compound B, and 82Rb) were considered. Motion correction accuracy was assessed using 4 different measures: change in volume mismatch between individual WB image volumes to assess gross body motion, change in displacement of a large organ (liver dome) within the torso due to respiration, change in intensity in small tumor nodules due to motion blur, and constancy of activity concentration levels. Results: Motion correction decreased gross body motion artifacts and reduced volume mismatch across dynamic frames by about 50%. Moreover, large-organ motion correction was assessed on the basis of correction of liver dome motion, which was removed entirely in about 70% of all cases. Motion correction also improved tumor intensity, resulting in an average increase in tumor SUVs by 15%. Large deformations seen in gated cardiac 82Rb images were managed without leading to anomalous distortions or substantial intensity changes in the resulting images. Finally, the constancy of activity concentration levels was reasonably preserved (,2% change) in large organs before and after motion correction. Conclusion: FALCON allows fast and accurate correction of rigid and nonrigid WB motion artifacts while being insensitive to scanner hardware or tracer distribution, making it applicable to a wide range of PET imaging scenarios.
KW - automation
KW - diffeomorphic registration
KW - motion correction
KW - quantification
KW - total-body PET
KW - whole-body PET
U2 - 10.2967/jnumed.122.265362
DO - 10.2967/jnumed.122.265362
M3 - Journal article
C2 - 37290795
AN - SCOPUS:85164208848
VL - 64
SP - 1145
EP - 1153
JO - The Journal of Nuclear Medicine
JF - The Journal of Nuclear Medicine
SN - 0161-5505
IS - 7
ER -
ID: 387827914