Bringing Radiotracing to Titanium-Based Antineoplastics

Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [⁴⁵Ti](salan)Ti(dipic)

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Gregory W. Severin
Nielsen, Carsten Haagen
Andreas I. Jensen
Jesper Fonslet
Kjær, Andreas
Fedor Zhuravlev

We present a novel solid-phase based ⁴⁵Ti radiolabeling methodology and the implementation of ⁴⁵Ti-PET in titanium-based antineoplastics using the showcase compound [⁴⁵Ti](salan)Ti(dipic). This development is intended to allow elucidation of the biodistribution and pharmacokinetics of promising new Ti-based therapeutics.

Originalsprog	Engelsk
Tidsskrift	Journal of Medicinal Chemistry
Vol/bind	58
Udgave nummer	18
Sider (fra-til)	7591-7595
Antal sider	5
ISSN	0022-2623
DOI	https://doi.org/10.1021/acs.jmedchem.5b01167
Status	Udgivet - 24 sep. 2015

ID: 147663189

Biomedicinsk Institut

Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [45Ti](salan)Ti(dipic)

Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [⁴⁵Ti](salan)Ti(dipic)