Variants near MC4R associate with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes
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Variants near MC4R associate with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes. / Zobel, Dorit P; Andreasen, Camilla H; Grarup, Niels; Eiberg, Hans; Sørensen, Thorkild I A; Sandbæk, Annelli; Lauritzen, Torsten; Borch-Johnsen, Knut; Jørgensen, Torben; Pedersen, Oluf; Hansen, Torben.
In: Diabetes, 2009, p. 757-764.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Variants near MC4R associate with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes
AU - Zobel, Dorit P
AU - Andreasen, Camilla H
AU - Grarup, Niels
AU - Eiberg, Hans
AU - Sørensen, Thorkild I A
AU - Sandbæk, Annelli
AU - Lauritzen, Torsten
AU - Borch-Johnsen, Knut
AU - Jørgensen, Torben
AU - Pedersen, Oluf
AU - Hansen, Torben
PY - 2009
Y1 - 2009
N2 - Objective: Variants downstream of the melanocortin-4 receptor gene (MC4R) have been reported to associate with obesity. We examined rs17782313, rs17700633, rs12970134, rs477181, rs502933, and rs4450508 near MC4R for association with obesity-related quantitative traits, obesity, and type 2 diabetes in Danish individuals. Research Design and Methods: The variants were investigated for association with obesity-related quantitative traits in 5,807 population-based-sampled individuals, for association with obesity in 14,940 individuals, and for association with type 2 diabetes in 8,821 individuals. Results: The minor risk alleles of rs17782313, rs17700633, and rs12970134 associated with BMI (effect per-allele: 0.25 [P=0.01], 0.23 [P=0.01], and 0.31 [P=7x10(-4)] kg/m(2), respectively); waist circumference (effect per-allele: 0.67 [P=0.006], 0.53 [P=0.02], and 0.85 [P=3x10(-4)] cm, respectively); and body weight (effect per-allele: 1.04 [P=6x10(-4)], 0.71 [P=0.01], and 1.16 [P=8x10(-5)] kg, respectively). In case-control studies of obesity defined by BMI the minor C-allele of rs17782313 associated with overweight/obesity and obesity (OR(overweight/obesity)=1.09, P=0.006; OR(obesity)=1.12, P=0.003). Similarly, the minor A-allele of rs17700633 associated with overweight/obesity and obesity (OR(overweight/obesity)=1.12, P=8x10(-5); OR(obesity)=1.16, P=2x10(-5)), and the minor A-allele of rs12970134 was also associated with overweight/obesity and obesity (OR(overweight/obesity)=1.13, P=2x10(-5); OR(obesity)=1.15, P=6x10(-5)). rs477181, rs502933, and rs4450508 were not statistically significantly associated with obesity in the Danish population. The frequency of the minor risk alleles of rs17782313 and rs12970134 were higher among patients with type 2 diabetes compared with glucose-tolerant individuals (OR=1.08, P=0.08; and OR=1.08, P=0.06, respectively); however, these borderline associations were abolished after adjustment for BMI. Conclusions: rs17782313, rs17700633, and rs12970134 near MC4R associate with measures of obesity in Danish individuals.
AB - Objective: Variants downstream of the melanocortin-4 receptor gene (MC4R) have been reported to associate with obesity. We examined rs17782313, rs17700633, rs12970134, rs477181, rs502933, and rs4450508 near MC4R for association with obesity-related quantitative traits, obesity, and type 2 diabetes in Danish individuals. Research Design and Methods: The variants were investigated for association with obesity-related quantitative traits in 5,807 population-based-sampled individuals, for association with obesity in 14,940 individuals, and for association with type 2 diabetes in 8,821 individuals. Results: The minor risk alleles of rs17782313, rs17700633, and rs12970134 associated with BMI (effect per-allele: 0.25 [P=0.01], 0.23 [P=0.01], and 0.31 [P=7x10(-4)] kg/m(2), respectively); waist circumference (effect per-allele: 0.67 [P=0.006], 0.53 [P=0.02], and 0.85 [P=3x10(-4)] cm, respectively); and body weight (effect per-allele: 1.04 [P=6x10(-4)], 0.71 [P=0.01], and 1.16 [P=8x10(-5)] kg, respectively). In case-control studies of obesity defined by BMI the minor C-allele of rs17782313 associated with overweight/obesity and obesity (OR(overweight/obesity)=1.09, P=0.006; OR(obesity)=1.12, P=0.003). Similarly, the minor A-allele of rs17700633 associated with overweight/obesity and obesity (OR(overweight/obesity)=1.12, P=8x10(-5); OR(obesity)=1.16, P=2x10(-5)), and the minor A-allele of rs12970134 was also associated with overweight/obesity and obesity (OR(overweight/obesity)=1.13, P=2x10(-5); OR(obesity)=1.15, P=6x10(-5)). rs477181, rs502933, and rs4450508 were not statistically significantly associated with obesity in the Danish population. The frequency of the minor risk alleles of rs17782313 and rs12970134 were higher among patients with type 2 diabetes compared with glucose-tolerant individuals (OR=1.08, P=0.08; and OR=1.08, P=0.06, respectively); however, these borderline associations were abolished after adjustment for BMI. Conclusions: rs17782313, rs17700633, and rs12970134 near MC4R associate with measures of obesity in Danish individuals.
U2 - 10.2337/db08-0620
DO - 10.2337/db08-0620
M3 - Journal article
C2 - 19073769
SP - 757
EP - 764
JO - Diabetes
JF - Diabetes
SN - 0012-1797
ER -
ID: 10000782