Use of cis-[18F] fluoro-proline for assessment of exercise-related collagen synthesis in musculoskeletal connective tissue

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Use of cis-[18F] fluoro-proline for assessment of exercise-related collagen synthesis in musculoskeletal connective tissue. / Skovgaard, Dorthe; Kjaer, Andreas; Heinemeier, Katja Maria; Brandt-Larsen, Malene; Madsen, Jacob; Kjaer, Michael.

In: P L o S One, Vol. 6, No. 2, 2011, p. 827-836.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Skovgaard, D, Kjaer, A, Heinemeier, KM, Brandt-Larsen, M, Madsen, J & Kjaer, M 2011, 'Use of cis-[18F] fluoro-proline for assessment of exercise-related collagen synthesis in musculoskeletal connective tissue', P L o S One, vol. 6, no. 2, pp. 827-836. https://doi.org/10.1371/journal.pone.0016678

APA

Skovgaard, D., Kjaer, A., Heinemeier, K. M., Brandt-Larsen, M., Madsen, J., & Kjaer, M. (2011). Use of cis-[18F] fluoro-proline for assessment of exercise-related collagen synthesis in musculoskeletal connective tissue. P L o S One, 6(2), 827-836. https://doi.org/10.1371/journal.pone.0016678

Vancouver

Skovgaard D, Kjaer A, Heinemeier KM, Brandt-Larsen M, Madsen J, Kjaer M. Use of cis-[18F] fluoro-proline for assessment of exercise-related collagen synthesis in musculoskeletal connective tissue. P L o S One. 2011;6(2):827-836. https://doi.org/10.1371/journal.pone.0016678

Author

Skovgaard, Dorthe ; Kjaer, Andreas ; Heinemeier, Katja Maria ; Brandt-Larsen, Malene ; Madsen, Jacob ; Kjaer, Michael. / Use of cis-[18F] fluoro-proline for assessment of exercise-related collagen synthesis in musculoskeletal connective tissue. In: P L o S One. 2011 ; Vol. 6, No. 2. pp. 827-836.

Bibtex

@article{6be67d24c20540e0aaf48a142472afe0,
title = "Use of cis-[18F] fluoro-proline for assessment of exercise-related collagen synthesis in musculoskeletal connective tissue",
abstract = "Protein turnover in collagen rich tissue is influenced by exercise, but can only with difficulty be studied in vivo due to use of invasive procedure. The present study was done to investigate the possibility of applying the PET-tracer, cis-[(18)F]fluoro-proline (cis-Fpro), for non-invasive assessment of collagen synthesis in rat musculoskeletal tissues at rest and following short-term (3 days) treadmill running. Musculoskeletal collagen synthesis was studied in rats at rest and 24 h post-exercise. At each session, rats were PET scanned at two time points following injection of cis-FPro: (60 and 240 min p.i). SUV were calculated for Achilles tendon, calf muscle and tibial bone. The PET-derived results were compared to mRNA expression of collagen type I and III. Tibial bone had the highest SUV that increased significantly (p",
keywords = "Animals, Biological Transport, Collagen, Collagen Type I, Collagen Type III, Connective Tissue, Male, Muscle, Skeletal, Physical Conditioning, Animal, Positron-Emission Tomography, Proline, RNA, Messenger, Rats, Rats, Wistar, Real-Time Polymerase Chain Reaction, Reproducibility of Results, Rest, Tendons",
author = "Dorthe Skovgaard and Andreas Kjaer and Heinemeier, {Katja Maria} and Malene Brandt-Larsen and Jacob Madsen and Michael Kjaer",
year = "2011",
doi = "10.1371/journal.pone.0016678",
language = "English",
volume = "6",
pages = "827--836",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

RIS

TY - JOUR

T1 - Use of cis-[18F] fluoro-proline for assessment of exercise-related collagen synthesis in musculoskeletal connective tissue

AU - Skovgaard, Dorthe

AU - Kjaer, Andreas

AU - Heinemeier, Katja Maria

AU - Brandt-Larsen, Malene

AU - Madsen, Jacob

AU - Kjaer, Michael

PY - 2011

Y1 - 2011

N2 - Protein turnover in collagen rich tissue is influenced by exercise, but can only with difficulty be studied in vivo due to use of invasive procedure. The present study was done to investigate the possibility of applying the PET-tracer, cis-[(18)F]fluoro-proline (cis-Fpro), for non-invasive assessment of collagen synthesis in rat musculoskeletal tissues at rest and following short-term (3 days) treadmill running. Musculoskeletal collagen synthesis was studied in rats at rest and 24 h post-exercise. At each session, rats were PET scanned at two time points following injection of cis-FPro: (60 and 240 min p.i). SUV were calculated for Achilles tendon, calf muscle and tibial bone. The PET-derived results were compared to mRNA expression of collagen type I and III. Tibial bone had the highest SUV that increased significantly (p

AB - Protein turnover in collagen rich tissue is influenced by exercise, but can only with difficulty be studied in vivo due to use of invasive procedure. The present study was done to investigate the possibility of applying the PET-tracer, cis-[(18)F]fluoro-proline (cis-Fpro), for non-invasive assessment of collagen synthesis in rat musculoskeletal tissues at rest and following short-term (3 days) treadmill running. Musculoskeletal collagen synthesis was studied in rats at rest and 24 h post-exercise. At each session, rats were PET scanned at two time points following injection of cis-FPro: (60 and 240 min p.i). SUV were calculated for Achilles tendon, calf muscle and tibial bone. The PET-derived results were compared to mRNA expression of collagen type I and III. Tibial bone had the highest SUV that increased significantly (p

KW - Animals

KW - Biological Transport

KW - Collagen

KW - Collagen Type I

KW - Collagen Type III

KW - Connective Tissue

KW - Male

KW - Muscle, Skeletal

KW - Physical Conditioning, Animal

KW - Positron-Emission Tomography

KW - Proline

KW - RNA, Messenger

KW - Rats

KW - Rats, Wistar

KW - Real-Time Polymerase Chain Reaction

KW - Reproducibility of Results

KW - Rest

KW - Tendons

U2 - 10.1371/journal.pone.0016678

DO - 10.1371/journal.pone.0016678

M3 - Journal article

C2 - 21347251

VL - 6

SP - 827

EP - 836

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 2

ER -

ID: 44914352