Urease-powered nanobots for radionuclide bladder cancer therapy

Research output: Contribution to journalJournal articleResearchpeer-review

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Urease-powered nanobots for radionuclide bladder cancer therapy. / Simó, Cristina; Serra-Casablancas, Meritxell; Hortelao, Ana C.; Di Carlo, Valerio; Guallar-Garrido, Sandra; Plaza-García, Sandra; Rabanal, Rosa Maria; Ramos-Cabrer, Pedro; Yagüe, Balbino; Aguado, Laura; Bardia, Lídia; Tosi, Sébastien; Gómez-Vallejo, Vanessa; Martín, Abraham; Patiño, Tania; Julián, Esther; Colombelli, Julien; Llop, Jordi; Sánchez, Samuel.

In: Nature Nanotechnology, Vol. 19, 2024, p. 554–564.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Simó, C, Serra-Casablancas, M, Hortelao, AC, Di Carlo, V, Guallar-Garrido, S, Plaza-García, S, Rabanal, RM, Ramos-Cabrer, P, Yagüe, B, Aguado, L, Bardia, L, Tosi, S, Gómez-Vallejo, V, Martín, A, Patiño, T, Julián, E, Colombelli, J, Llop, J & Sánchez, S 2024, 'Urease-powered nanobots for radionuclide bladder cancer therapy', Nature Nanotechnology, vol. 19, pp. 554–564. https://doi.org/10.1038/s41565-023-01577-y

APA

Simó, C., Serra-Casablancas, M., Hortelao, A. C., Di Carlo, V., Guallar-Garrido, S., Plaza-García, S., Rabanal, R. M., Ramos-Cabrer, P., Yagüe, B., Aguado, L., Bardia, L., Tosi, S., Gómez-Vallejo, V., Martín, A., Patiño, T., Julián, E., Colombelli, J., Llop, J., & Sánchez, S. (2024). Urease-powered nanobots for radionuclide bladder cancer therapy. Nature Nanotechnology, 19, 554–564. https://doi.org/10.1038/s41565-023-01577-y

Vancouver

Simó C, Serra-Casablancas M, Hortelao AC, Di Carlo V, Guallar-Garrido S, Plaza-García S et al. Urease-powered nanobots for radionuclide bladder cancer therapy. Nature Nanotechnology. 2024;19:554–564. https://doi.org/10.1038/s41565-023-01577-y

Author

Simó, Cristina ; Serra-Casablancas, Meritxell ; Hortelao, Ana C. ; Di Carlo, Valerio ; Guallar-Garrido, Sandra ; Plaza-García, Sandra ; Rabanal, Rosa Maria ; Ramos-Cabrer, Pedro ; Yagüe, Balbino ; Aguado, Laura ; Bardia, Lídia ; Tosi, Sébastien ; Gómez-Vallejo, Vanessa ; Martín, Abraham ; Patiño, Tania ; Julián, Esther ; Colombelli, Julien ; Llop, Jordi ; Sánchez, Samuel. / Urease-powered nanobots for radionuclide bladder cancer therapy. In: Nature Nanotechnology. 2024 ; Vol. 19. pp. 554–564.

Bibtex

@article{f79f3d6c715e43a48afc1c2096fa58b6,
title = "Urease-powered nanobots for radionuclide bladder cancer therapy",
abstract = "Bladder cancer treatment via intravesical drug administration achieves reasonable survival rates but suffers from low therapeutic efficacy. To address the latter, self-propelled nanoparticles or nanobots have been proposed, taking advantage of their enhanced diffusion and mixing capabilities in urine when compared with conventional drugs or passive nanoparticles. However, the translational capabilities of nanobots in treating bladder cancer are underexplored. Here, we tested radiolabelled mesoporous silica-based urease-powered nanobots in an orthotopic mouse model of bladder cancer. In vivo and ex vivo results demonstrated enhanced nanobot accumulation at the tumour site, with an eightfold increase revealed by positron emission tomography in vivo. Label-free optical contrast based on polarization-dependent scattered light-sheet microscopy of cleared bladders confirmed tumour penetration by nanobots ex vivo. Treating tumour-bearing mice with intravesically administered radio-iodinated nanobots for radionuclide therapy resulted in a tumour size reduction of about 90%, positioning nanobots as efficient delivery nanosystems for bladder cancer therapy.",
author = "Cristina Sim{\'o} and Meritxell Serra-Casablancas and Hortelao, {Ana C.} and {Di Carlo}, Valerio and Sandra Guallar-Garrido and Sandra Plaza-Garc{\'i}a and Rabanal, {Rosa Maria} and Pedro Ramos-Cabrer and Balbino Yag{\"u}e and Laura Aguado and L{\'i}dia Bardia and S{\'e}bastien Tosi and Vanessa G{\'o}mez-Vallejo and Abraham Mart{\'i}n and Tania Pati{\~n}o and Esther Juli{\'a}n and Julien Colombelli and Jordi Llop and Samuel S{\'a}nchez",
note = "Publisher Copyright: {\textcopyright} 2024, The Author(s).",
year = "2024",
doi = "10.1038/s41565-023-01577-y",
language = "English",
volume = "19",
pages = "554–564",
journal = "Nature Nanotechnology",
issn = "1748-3387",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Urease-powered nanobots for radionuclide bladder cancer therapy

AU - Simó, Cristina

AU - Serra-Casablancas, Meritxell

AU - Hortelao, Ana C.

AU - Di Carlo, Valerio

AU - Guallar-Garrido, Sandra

AU - Plaza-García, Sandra

AU - Rabanal, Rosa Maria

AU - Ramos-Cabrer, Pedro

AU - Yagüe, Balbino

AU - Aguado, Laura

AU - Bardia, Lídia

AU - Tosi, Sébastien

AU - Gómez-Vallejo, Vanessa

AU - Martín, Abraham

AU - Patiño, Tania

AU - Julián, Esther

AU - Colombelli, Julien

AU - Llop, Jordi

AU - Sánchez, Samuel

N1 - Publisher Copyright: © 2024, The Author(s).

PY - 2024

Y1 - 2024

N2 - Bladder cancer treatment via intravesical drug administration achieves reasonable survival rates but suffers from low therapeutic efficacy. To address the latter, self-propelled nanoparticles or nanobots have been proposed, taking advantage of their enhanced diffusion and mixing capabilities in urine when compared with conventional drugs or passive nanoparticles. However, the translational capabilities of nanobots in treating bladder cancer are underexplored. Here, we tested radiolabelled mesoporous silica-based urease-powered nanobots in an orthotopic mouse model of bladder cancer. In vivo and ex vivo results demonstrated enhanced nanobot accumulation at the tumour site, with an eightfold increase revealed by positron emission tomography in vivo. Label-free optical contrast based on polarization-dependent scattered light-sheet microscopy of cleared bladders confirmed tumour penetration by nanobots ex vivo. Treating tumour-bearing mice with intravesically administered radio-iodinated nanobots for radionuclide therapy resulted in a tumour size reduction of about 90%, positioning nanobots as efficient delivery nanosystems for bladder cancer therapy.

AB - Bladder cancer treatment via intravesical drug administration achieves reasonable survival rates but suffers from low therapeutic efficacy. To address the latter, self-propelled nanoparticles or nanobots have been proposed, taking advantage of their enhanced diffusion and mixing capabilities in urine when compared with conventional drugs or passive nanoparticles. However, the translational capabilities of nanobots in treating bladder cancer are underexplored. Here, we tested radiolabelled mesoporous silica-based urease-powered nanobots in an orthotopic mouse model of bladder cancer. In vivo and ex vivo results demonstrated enhanced nanobot accumulation at the tumour site, with an eightfold increase revealed by positron emission tomography in vivo. Label-free optical contrast based on polarization-dependent scattered light-sheet microscopy of cleared bladders confirmed tumour penetration by nanobots ex vivo. Treating tumour-bearing mice with intravesically administered radio-iodinated nanobots for radionuclide therapy resulted in a tumour size reduction of about 90%, positioning nanobots as efficient delivery nanosystems for bladder cancer therapy.

U2 - 10.1038/s41565-023-01577-y

DO - 10.1038/s41565-023-01577-y

M3 - Journal article

C2 - 38225356

AN - SCOPUS:85182459825

VL - 19

SP - 554

EP - 564

JO - Nature Nanotechnology

JF - Nature Nanotechnology

SN - 1748-3387

ER -

ID: 380695287