Toward Tailored Rehabilitation by Implementation of a Novel Musculoskeletal Finite Element Analysis Pipeline

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Toward Tailored Rehabilitation by Implementation of a Novel Musculoskeletal Finite Element Analysis Pipeline. / Esrafilian, Amir; Stenroth, Lauri; Mononen, Mika E.; Vartiainen, Paavo; Tanska, Petri; Karjalainen, Pasi A.; Suomalainen, Juha Sampo; Arokoski, Jari P.A.; Saxby, David J.; Lloyd, David G.; Korhonen, Rami K.

In: IEEE Transactions on Neural Systems and Rehabilitation Engineering, Vol. 30, 2022, p. 789-802.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Esrafilian, A, Stenroth, L, Mononen, ME, Vartiainen, P, Tanska, P, Karjalainen, PA, Suomalainen, JS, Arokoski, JPA, Saxby, DJ, Lloyd, DG & Korhonen, RK 2022, 'Toward Tailored Rehabilitation by Implementation of a Novel Musculoskeletal Finite Element Analysis Pipeline', IEEE Transactions on Neural Systems and Rehabilitation Engineering, vol. 30, pp. 789-802. https://doi.org/10.1109/TNSRE.2022.3159685

APA

Esrafilian, A., Stenroth, L., Mononen, M. E., Vartiainen, P., Tanska, P., Karjalainen, P. A., Suomalainen, J. S., Arokoski, J. P. A., Saxby, D. J., Lloyd, D. G., & Korhonen, R. K. (2022). Toward Tailored Rehabilitation by Implementation of a Novel Musculoskeletal Finite Element Analysis Pipeline. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 30, 789-802. https://doi.org/10.1109/TNSRE.2022.3159685

Vancouver

Esrafilian A, Stenroth L, Mononen ME, Vartiainen P, Tanska P, Karjalainen PA et al. Toward Tailored Rehabilitation by Implementation of a Novel Musculoskeletal Finite Element Analysis Pipeline. IEEE Transactions on Neural Systems and Rehabilitation Engineering. 2022;30:789-802. https://doi.org/10.1109/TNSRE.2022.3159685

Author

Esrafilian, Amir ; Stenroth, Lauri ; Mononen, Mika E. ; Vartiainen, Paavo ; Tanska, Petri ; Karjalainen, Pasi A. ; Suomalainen, Juha Sampo ; Arokoski, Jari P.A. ; Saxby, David J. ; Lloyd, David G. ; Korhonen, Rami K. / Toward Tailored Rehabilitation by Implementation of a Novel Musculoskeletal Finite Element Analysis Pipeline. In: IEEE Transactions on Neural Systems and Rehabilitation Engineering. 2022 ; Vol. 30. pp. 789-802.

Bibtex

@article{cd6f17463ae048f49f15a8c38922db1c,
title = "Toward Tailored Rehabilitation by Implementation of a Novel Musculoskeletal Finite Element Analysis Pipeline",
abstract = "Tissue-level mechanics (e.g., stress and strain) are important factors governing tissue remodeling and development of knee osteoarthritis (KOA), and hence, the success of physical rehabilitation. To date, no clinically feasible analysis toolbox has been introduced and used to inform clinical decision making with subject-specific in-depth joint mechanics of different activities. Herein, we utilized a rapid state-of-the-art electromyography-assisted musculoskeletal finite element analysis toolbox with fibril-reinforced poro(visco)elastic cartilages and menisci to investigate knee mechanics in different activities. Tissue mechanical responses, believed to govern collagen damage, cell death, and fixed charge density loss of proteoglycans, were characterized within 15 patients with KOA while various daily activities and rehabilitation exercises were performed. Results showed more inter-participant variation in joint mechanics during rehabilitation exercises compared to daily activities. Accordingly, the devised workflow may be used for designing subject-specific rehabilitation protocols. Further, results showed the potential to tailor rehabilitation exercises, or assess capacity for daily activity modifications, to optimally load knee tissue, especially when mechanically-induced cartilage degeneration and adaptation are of interest. ",
keywords = "clinical assessment, daily activities, electromyography assisted musculoskeletal modeling, Knee osteoarthritis, rehabilitation exercises",
author = "Amir Esrafilian and Lauri Stenroth and Mononen, {Mika E.} and Paavo Vartiainen and Petri Tanska and Karjalainen, {Pasi A.} and Suomalainen, {Juha Sampo} and Arokoski, {Jari P.A.} and Saxby, {David J.} and Lloyd, {David G.} and Korhonen, {Rami K.}",
note = "Publisher Copyright: {\textcopyright} 2001-2011 IEEE.",
year = "2022",
doi = "10.1109/TNSRE.2022.3159685",
language = "English",
volume = "30",
pages = "789--802",
journal = "IEEE Transactions on Neural Systems and Rehabilitation Engineering",
issn = "1534-4320",
publisher = "Institute of Electrical and Electronics Engineers Inc.",

}

RIS

TY - JOUR

T1 - Toward Tailored Rehabilitation by Implementation of a Novel Musculoskeletal Finite Element Analysis Pipeline

AU - Esrafilian, Amir

AU - Stenroth, Lauri

AU - Mononen, Mika E.

AU - Vartiainen, Paavo

AU - Tanska, Petri

AU - Karjalainen, Pasi A.

AU - Suomalainen, Juha Sampo

AU - Arokoski, Jari P.A.

AU - Saxby, David J.

AU - Lloyd, David G.

AU - Korhonen, Rami K.

N1 - Publisher Copyright: © 2001-2011 IEEE.

PY - 2022

Y1 - 2022

N2 - Tissue-level mechanics (e.g., stress and strain) are important factors governing tissue remodeling and development of knee osteoarthritis (KOA), and hence, the success of physical rehabilitation. To date, no clinically feasible analysis toolbox has been introduced and used to inform clinical decision making with subject-specific in-depth joint mechanics of different activities. Herein, we utilized a rapid state-of-the-art electromyography-assisted musculoskeletal finite element analysis toolbox with fibril-reinforced poro(visco)elastic cartilages and menisci to investigate knee mechanics in different activities. Tissue mechanical responses, believed to govern collagen damage, cell death, and fixed charge density loss of proteoglycans, were characterized within 15 patients with KOA while various daily activities and rehabilitation exercises were performed. Results showed more inter-participant variation in joint mechanics during rehabilitation exercises compared to daily activities. Accordingly, the devised workflow may be used for designing subject-specific rehabilitation protocols. Further, results showed the potential to tailor rehabilitation exercises, or assess capacity for daily activity modifications, to optimally load knee tissue, especially when mechanically-induced cartilage degeneration and adaptation are of interest.

AB - Tissue-level mechanics (e.g., stress and strain) are important factors governing tissue remodeling and development of knee osteoarthritis (KOA), and hence, the success of physical rehabilitation. To date, no clinically feasible analysis toolbox has been introduced and used to inform clinical decision making with subject-specific in-depth joint mechanics of different activities. Herein, we utilized a rapid state-of-the-art electromyography-assisted musculoskeletal finite element analysis toolbox with fibril-reinforced poro(visco)elastic cartilages and menisci to investigate knee mechanics in different activities. Tissue mechanical responses, believed to govern collagen damage, cell death, and fixed charge density loss of proteoglycans, were characterized within 15 patients with KOA while various daily activities and rehabilitation exercises were performed. Results showed more inter-participant variation in joint mechanics during rehabilitation exercises compared to daily activities. Accordingly, the devised workflow may be used for designing subject-specific rehabilitation protocols. Further, results showed the potential to tailor rehabilitation exercises, or assess capacity for daily activity modifications, to optimally load knee tissue, especially when mechanically-induced cartilage degeneration and adaptation are of interest.

KW - clinical assessment

KW - daily activities

KW - electromyography assisted musculoskeletal modeling

KW - Knee osteoarthritis

KW - rehabilitation exercises

UR - http://www.scopus.com/inward/record.url?scp=85126531891&partnerID=8YFLogxK

U2 - 10.1109/TNSRE.2022.3159685

DO - 10.1109/TNSRE.2022.3159685

M3 - Journal article

C2 - 35286263

AN - SCOPUS:85126531891

VL - 30

SP - 789

EP - 802

JO - IEEE Transactions on Neural Systems and Rehabilitation Engineering

JF - IEEE Transactions on Neural Systems and Rehabilitation Engineering

SN - 1534-4320

ER -

ID: 311607526