Tolerable Duration of Warm Ischaemia After Circulatory Death Is Safe For At Least One Hour in Porcine Lungs: Functional Assessment with Ex Vivo Lung Perfusion

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Tolerable Duration of Warm Ischaemia After Circulatory Death Is Safe For At Least One Hour in Porcine Lungs : Functional Assessment with Ex Vivo Lung Perfusion. / Hebsgaard, Mathilde M. B.; Kissow, Hannelouise; Lilleør, Nikolaj B.; Lorenzen, Ulver S.; Chemtob, Raphaelle A.; Møller-Sørensen, Hasse; Olsen, Peter S.; Møller, Christian H.

In: Heart Surgery Forum, Vol. 25, No. 1, 2022, p. E48-E52.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hebsgaard, MMB, Kissow, H, Lilleør, NB, Lorenzen, US, Chemtob, RA, Møller-Sørensen, H, Olsen, PS & Møller, CH 2022, 'Tolerable Duration of Warm Ischaemia After Circulatory Death Is Safe For At Least One Hour in Porcine Lungs: Functional Assessment with Ex Vivo Lung Perfusion', Heart Surgery Forum, vol. 25, no. 1, pp. E48-E52. https://doi.org/10.1532/hsf.4347

APA

Hebsgaard, M. M. B., Kissow, H., Lilleør, N. B., Lorenzen, U. S., Chemtob, R. A., Møller-Sørensen, H., Olsen, P. S., & Møller, C. H. (2022). Tolerable Duration of Warm Ischaemia After Circulatory Death Is Safe For At Least One Hour in Porcine Lungs: Functional Assessment with Ex Vivo Lung Perfusion. Heart Surgery Forum, 25(1), E48-E52. https://doi.org/10.1532/hsf.4347

Vancouver

Hebsgaard MMB, Kissow H, Lilleør NB, Lorenzen US, Chemtob RA, Møller-Sørensen H et al. Tolerable Duration of Warm Ischaemia After Circulatory Death Is Safe For At Least One Hour in Porcine Lungs: Functional Assessment with Ex Vivo Lung Perfusion. Heart Surgery Forum. 2022;25(1):E48-E52. https://doi.org/10.1532/hsf.4347

Author

Hebsgaard, Mathilde M. B. ; Kissow, Hannelouise ; Lilleør, Nikolaj B. ; Lorenzen, Ulver S. ; Chemtob, Raphaelle A. ; Møller-Sørensen, Hasse ; Olsen, Peter S. ; Møller, Christian H. / Tolerable Duration of Warm Ischaemia After Circulatory Death Is Safe For At Least One Hour in Porcine Lungs : Functional Assessment with Ex Vivo Lung Perfusion. In: Heart Surgery Forum. 2022 ; Vol. 25, No. 1. pp. E48-E52.

Bibtex

@article{46ca09eecdd6470fa0c48e1fd5599078,
title = "Tolerable Duration of Warm Ischaemia After Circulatory Death Is Safe For At Least One Hour in Porcine Lungs: Functional Assessment with Ex Vivo Lung Perfusion",
abstract = "Background: Lungs from donation after circulatory death (DCD) may be an underused resource for transplantation. The aim was to investigate, with a DCD pig model, if it was possible to recondition lungs exposed for up to 2 h of warm ischaemia with ex vivo lung perfusion (EVLP).Methods: Danish domestic pigs (N = 17) were randomized into three groups. In the two study groups, lungs were exposed to either 1 or 2 h of warm ischaemia. All lungs were reconditioned and evaluated after 83 ± 38 minutes of perfusion at FiO2 1.0 and 0.21 with EVLP. Outcome measures were gas exchange, pulmonary physiology, inflammatory markers, and histopathologic assessment score.Results: Lungs exposed for 2 h of warm ischaemia did not meet the criteria: PaO2 > 13 kPa required for donation compared with lungs subjected to 0 and 1 h of warm ischaemia (11.0 kPa vs. 14.2 kPa, P < 0.001). These lungs also developed an increased amount of foam and fluid in the airways. No differences in PaCO2, compliance, or pulmonary vascular resistance were observed.Conclusion: Results show that while lungs subjected to 0 or 1 h of warm ischaemia meet the criteria for transplantation based on EVLP evaluation, lungs subjected to 2 h of warm ischaemia did not.",
author = "Hebsgaard, {Mathilde M. B.} and Hannelouise Kissow and Lille{\o}r, {Nikolaj B.} and Lorenzen, {Ulver S.} and Chemtob, {Raphaelle A.} and Hasse M{\o}ller-S{\o}rensen and Olsen, {Peter S.} and M{\o}ller, {Christian H.}",
year = "2022",
doi = "10.1532/hsf.4347",
language = "English",
volume = "25",
pages = "E48--E52",
journal = "Heart Surgery Forum",
issn = "1098-3511",
publisher = "TheHeart Surgery Forum",
number = "1",

}

RIS

TY - JOUR

T1 - Tolerable Duration of Warm Ischaemia After Circulatory Death Is Safe For At Least One Hour in Porcine Lungs

T2 - Functional Assessment with Ex Vivo Lung Perfusion

AU - Hebsgaard, Mathilde M. B.

AU - Kissow, Hannelouise

AU - Lilleør, Nikolaj B.

AU - Lorenzen, Ulver S.

AU - Chemtob, Raphaelle A.

AU - Møller-Sørensen, Hasse

AU - Olsen, Peter S.

AU - Møller, Christian H.

PY - 2022

Y1 - 2022

N2 - Background: Lungs from donation after circulatory death (DCD) may be an underused resource for transplantation. The aim was to investigate, with a DCD pig model, if it was possible to recondition lungs exposed for up to 2 h of warm ischaemia with ex vivo lung perfusion (EVLP).Methods: Danish domestic pigs (N = 17) were randomized into three groups. In the two study groups, lungs were exposed to either 1 or 2 h of warm ischaemia. All lungs were reconditioned and evaluated after 83 ± 38 minutes of perfusion at FiO2 1.0 and 0.21 with EVLP. Outcome measures were gas exchange, pulmonary physiology, inflammatory markers, and histopathologic assessment score.Results: Lungs exposed for 2 h of warm ischaemia did not meet the criteria: PaO2 > 13 kPa required for donation compared with lungs subjected to 0 and 1 h of warm ischaemia (11.0 kPa vs. 14.2 kPa, P < 0.001). These lungs also developed an increased amount of foam and fluid in the airways. No differences in PaCO2, compliance, or pulmonary vascular resistance were observed.Conclusion: Results show that while lungs subjected to 0 or 1 h of warm ischaemia meet the criteria for transplantation based on EVLP evaluation, lungs subjected to 2 h of warm ischaemia did not.

AB - Background: Lungs from donation after circulatory death (DCD) may be an underused resource for transplantation. The aim was to investigate, with a DCD pig model, if it was possible to recondition lungs exposed for up to 2 h of warm ischaemia with ex vivo lung perfusion (EVLP).Methods: Danish domestic pigs (N = 17) were randomized into three groups. In the two study groups, lungs were exposed to either 1 or 2 h of warm ischaemia. All lungs were reconditioned and evaluated after 83 ± 38 minutes of perfusion at FiO2 1.0 and 0.21 with EVLP. Outcome measures were gas exchange, pulmonary physiology, inflammatory markers, and histopathologic assessment score.Results: Lungs exposed for 2 h of warm ischaemia did not meet the criteria: PaO2 > 13 kPa required for donation compared with lungs subjected to 0 and 1 h of warm ischaemia (11.0 kPa vs. 14.2 kPa, P < 0.001). These lungs also developed an increased amount of foam and fluid in the airways. No differences in PaCO2, compliance, or pulmonary vascular resistance were observed.Conclusion: Results show that while lungs subjected to 0 or 1 h of warm ischaemia meet the criteria for transplantation based on EVLP evaluation, lungs subjected to 2 h of warm ischaemia did not.

U2 - 10.1532/hsf.4347

DO - 10.1532/hsf.4347

M3 - Journal article

C2 - 35238302

VL - 25

SP - E48-E52

JO - Heart Surgery Forum

JF - Heart Surgery Forum

SN - 1098-3511

IS - 1

ER -

ID: 290668847