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Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. / Elks, Cathy E; Perry, John R B; Sulem, Patrick; Chasman, Daniel I; Franceschini, Nora; He, Chunyan; Lunetta, Kathryn L; Visser, Jenny A; Byrne, Enda M; Cousminer, Diana L; Gudbjartsson, Daniel F; Esko, Tõnu; Feenstra, Bjarke; Hottenga, Jouke-Jan; Koller, Daniel L; Kutalik, Zoltán; Lin, Peng; Mangino, Massimo; Marongiu, Mara; McArdle, Patrick F; Smith, Albert V; Stolk, Lisette; van Wingerden, Sophie H; Zhao, Jing Hua; Albrecht, Eva; Corre, Tanguy; Ingelsson, Erik; Hayward, Caroline; Magnusson, Patrik K E; Smith, Erin N; Ulivi, Shelia; Warrington, Nicole M; Zgaga, Lina; Alavere, Helen; Amin, Najaf; Aspelund, Thor; Bandinelli, Stefania; Barroso, Inês; Berenson, Gerald S; Bergmann, Sven; Blackburn, Hannah; Boerwinkle, Eric; Buring, Julie E; Busonero, Fabio; Campbell, Harry; Chanock, Stephen J; Chen, Wei; Cornelis, Marilyn C; Couper, David; Oskari Kilpeläinen, Tuomas; GIANT Consortium.
In:
Nature Genetics, Vol. 42, No. 12, 12.2010, p. 1077-85.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Elks, CE, Perry, JRB, Sulem, P, Chasman, DI, Franceschini, N, He, C, Lunetta, KL, Visser, JA, Byrne, EM, Cousminer, DL, Gudbjartsson, DF, Esko, T, Feenstra, B, Hottenga, J-J, Koller, DL, Kutalik, Z, Lin, P, Mangino, M, Marongiu, M, McArdle, PF, Smith, AV, Stolk, L, van Wingerden, SH, Zhao, JH, Albrecht, E, Corre, T, Ingelsson, E, Hayward, C, Magnusson, PKE, Smith, EN, Ulivi, S, Warrington, NM, Zgaga, L, Alavere, H, Amin, N, Aspelund, T, Bandinelli, S, Barroso, I, Berenson, GS, Bergmann, S, Blackburn, H, Boerwinkle, E, Buring, JE, Busonero, F, Campbell, H, Chanock, SJ, Chen, W, Cornelis, MC, Couper, D
, Oskari Kilpeläinen, T & GIANT Consortium 2010, '
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies',
Nature Genetics, vol. 42, no. 12, pp. 1077-85.
https://doi.org/10.1038/ng.714APA
Elks, C. E., Perry, J. R. B., Sulem, P., Chasman, D. I., Franceschini, N., He, C., Lunetta, K. L., Visser, J. A., Byrne, E. M., Cousminer, D. L., Gudbjartsson, D. F., Esko, T., Feenstra, B., Hottenga, J-J., Koller, D. L., Kutalik, Z., Lin, P., Mangino, M., Marongiu, M., ... GIANT Consortium (2010).
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
Nature Genetics,
42(12), 1077-85.
https://doi.org/10.1038/ng.714Vancouver
Elks CE, Perry JRB, Sulem P, Chasman DI, Franceschini N, He C et al.
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
Nature Genetics. 2010 Dec;42(12):1077-85.
https://doi.org/10.1038/ng.714Author
Elks, Cathy E ; Perry, John R B ; Sulem, Patrick ; Chasman, Daniel I ; Franceschini, Nora ; He, Chunyan ; Lunetta, Kathryn L ; Visser, Jenny A ; Byrne, Enda M ; Cousminer, Diana L ; Gudbjartsson, Daniel F ; Esko, Tõnu ; Feenstra, Bjarke ; Hottenga, Jouke-Jan ; Koller, Daniel L ; Kutalik, Zoltán ; Lin, Peng ; Mangino, Massimo ; Marongiu, Mara ; McArdle, Patrick F ; Smith, Albert V ; Stolk, Lisette ; van Wingerden, Sophie H ; Zhao, Jing Hua ; Albrecht, Eva ; Corre, Tanguy ; Ingelsson, Erik ; Hayward, Caroline ; Magnusson, Patrik K E ; Smith, Erin N ; Ulivi, Shelia ; Warrington, Nicole M ; Zgaga, Lina ; Alavere, Helen ; Amin, Najaf ; Aspelund, Thor ; Bandinelli, Stefania ; Barroso, Inês ; Berenson, Gerald S ; Bergmann, Sven ; Blackburn, Hannah ; Boerwinkle, Eric ; Buring, Julie E ; Busonero, Fabio ; Campbell, Harry ; Chanock, Stephen J ; Chen, Wei ; Cornelis, Marilyn C ; Couper, David ; Oskari Kilpeläinen, Tuomas ; GIANT Consortium. / Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. In: Nature Genetics. 2010 ; Vol. 42, No. 12. pp. 1077-85.
Bibtex
@article{e9cc162021fa475bb86e3404f05b208a,
title = "Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies",
abstract = "To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10⁻⁶⁰) and 9q31.2 (P = 2.2 × 10⁻³³), we identified 30 new menarche loci (all P <5 × 10⁻⁸) and found suggestive evidence for a further 10 loci (P <1.9 × 10⁻⁶). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.",
keywords = "Adolescent, Aging, Body Height, Body Size, Child, DNA Copy Number Variations, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Inheritance Patterns, Menarche, Obesity, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Reproducibility of Results, Time Factors",
author = "Elks, {Cathy E} and Perry, {John R B} and Patrick Sulem and Chasman, {Daniel I} and Nora Franceschini and Chunyan He and Lunetta, {Kathryn L} and Visser, {Jenny A} and Byrne, {Enda M} and Cousminer, {Diana L} and Gudbjartsson, {Daniel F} and T{\~o}nu Esko and Bjarke Feenstra and Jouke-Jan Hottenga and Koller, {Daniel L} and Zolt{\'a}n Kutalik and Peng Lin and Massimo Mangino and Mara Marongiu and McArdle, {Patrick F} and Smith, {Albert V} and Lisette Stolk and {van Wingerden}, {Sophie H} and Zhao, {Jing Hua} and Eva Albrecht and Tanguy Corre and Erik Ingelsson and Caroline Hayward and Magnusson, {Patrik K E} and Smith, {Erin N} and Shelia Ulivi and Warrington, {Nicole M} and Lina Zgaga and Helen Alavere and Najaf Amin and Thor Aspelund and Stefania Bandinelli and In{\^e}s Barroso and Berenson, {Gerald S} and Sven Bergmann and Hannah Blackburn and Eric Boerwinkle and Buring, {Julie E} and Fabio Busonero and Harry Campbell and Chanock, {Stephen J} and Wei Chen and Cornelis, {Marilyn C} and David Couper and {Oskari Kilpel{\"a}inen}, Tuomas and {GIANT Consortium}",
year = "2010",
month = dec,
doi = "10.1038/ng.714",
language = "English",
volume = "42",
pages = "1077--85",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "12",
}
RIS
TY - JOUR
T1 - Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
AU - Elks, Cathy E
AU - Perry, John R B
AU - Sulem, Patrick
AU - Chasman, Daniel I
AU - Franceschini, Nora
AU - He, Chunyan
AU - Lunetta, Kathryn L
AU - Visser, Jenny A
AU - Byrne, Enda M
AU - Cousminer, Diana L
AU - Gudbjartsson, Daniel F
AU - Esko, Tõnu
AU - Feenstra, Bjarke
AU - Hottenga, Jouke-Jan
AU - Koller, Daniel L
AU - Kutalik, Zoltán
AU - Lin, Peng
AU - Mangino, Massimo
AU - Marongiu, Mara
AU - McArdle, Patrick F
AU - Smith, Albert V
AU - Stolk, Lisette
AU - van Wingerden, Sophie H
AU - Zhao, Jing Hua
AU - Albrecht, Eva
AU - Corre, Tanguy
AU - Ingelsson, Erik
AU - Hayward, Caroline
AU - Magnusson, Patrik K E
AU - Smith, Erin N
AU - Ulivi, Shelia
AU - Warrington, Nicole M
AU - Zgaga, Lina
AU - Alavere, Helen
AU - Amin, Najaf
AU - Aspelund, Thor
AU - Bandinelli, Stefania
AU - Barroso, Inês
AU - Berenson, Gerald S
AU - Bergmann, Sven
AU - Blackburn, Hannah
AU - Boerwinkle, Eric
AU - Buring, Julie E
AU - Busonero, Fabio
AU - Campbell, Harry
AU - Chanock, Stephen J
AU - Chen, Wei
AU - Cornelis, Marilyn C
AU - Couper, David
AU - Oskari Kilpeläinen, Tuomas
AU - GIANT Consortium
PY - 2010/12
Y1 - 2010/12
N2 - To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10⁻⁶⁰) and 9q31.2 (P = 2.2 × 10⁻³³), we identified 30 new menarche loci (all P <5 × 10⁻⁸) and found suggestive evidence for a further 10 loci (P <1.9 × 10⁻⁶). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.
AB - To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10⁻⁶⁰) and 9q31.2 (P = 2.2 × 10⁻³³), we identified 30 new menarche loci (all P <5 × 10⁻⁸) and found suggestive evidence for a further 10 loci (P <1.9 × 10⁻⁶). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.
KW - Adolescent
KW - Aging
KW - Body Height
KW - Body Size
KW - Child
KW - DNA Copy Number Variations
KW - Female
KW - Genetic Loci
KW - Genetic Predisposition to Disease
KW - Genome-Wide Association Study
KW - Humans
KW - Inheritance Patterns
KW - Menarche
KW - Obesity
KW - Polymorphism, Single Nucleotide
KW - Quantitative Trait Loci
KW - Reproducibility of Results
KW - Time Factors
U2 - 10.1038/ng.714
DO - 10.1038/ng.714
M3 - Journal article
C2 - 21102462
VL - 42
SP - 1077
EP - 1085
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 12
ER -
