Therapeutic levels of erythropoietin (EPO) achieved after gene electrotransfer to skin in mice
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Gene electrotransfer refers to gene transfection by electroporation and is an effective non-viral method for delivering naked DNA into cells and tissues. This study presents data from gene electrotransfer with erythropoietin (EPO) to mouse skin. Nine-week-old female NMRI mice received one, two or three intradermal injections of 50 microg EPO plasmid and were subsequently electroporated. With plate electrodes and 100 microg of EPO, a significant increase in hemoglobin (P
| Original language | English |
|---|---|
| Journal | Gene Therapy (Basingstoke) |
| Volume | 17 |
| Issue number | 9 |
| Pages (from-to) | 1077-84 |
| Number of pages | 8 |
| ISSN | 0969-7128 |
| DOIs | |
| Publication status | Published - 1 Sep 2010 |
ID: 34143397