Theoretical considerations on the use of diffusion weighted MRI for detection of in vivo brain electroporation
Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
Electroporation (EP), the permeabilization of cellular membrane by externally applied voltage pulses, has shown its potential as treatment for cancer when combined with chemotherapeutic agents (electrochemotherapy) and genes (gene electrotransfer). Imaging biomarkers for EP based treatments are therefore needed for monitoring the response both during medical procedures and follow-up. In this paper we focus on diffusion weighted magnetic resonance imaging (DW-MRI) as a non-invasive and quantitative tool for detection of electroporation of brain tissue. We discuss the impact of issues such as joule heating, tissue perfusion, cell morphology on the DW-MRI measurement. We conclude that DW-MRI may potentially be used for direct detection of induced membrane permeabilization, but a number of fundamental challenges need to be dealt with.
Original language | English |
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Title of host publication | 6th European Conference of the International Federation for Medical and Biological Engineering - MBEC 2014 |
Editors | Igor Lackovic, Darko Vasic |
Number of pages | 4 |
Publisher | Springer Verlag |
Publication date | 2015 |
Pages | 837-840 |
ISBN (Electronic) | 9783319111278 |
DOIs | |
Publication status | Published - 2015 |
Event | 6th European Conference of the International Federation for Medical and Biological Engineering, MBEC 2014 - Dubrovnik, Croatia Duration: 7 Sep 2014 → 11 Sep 2014 |
Conference
Conference | 6th European Conference of the International Federation for Medical and Biological Engineering, MBEC 2014 |
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Land | Croatia |
By | Dubrovnik |
Periode | 07/09/2014 → 11/09/2014 |
Sponsor | International Federation for Medical and Biological Engineering |
Series | IFMBE Proceedings |
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Volume | 45 |
ISSN | 1680-0737 |
Bibliographical note
Publisher Copyright:
© Springer International Publishing Switzerland 2015.
- Cell morphology, Diffusion weighted MRI, Electroporation, Membrane permeabilization, Tissue reaction
Research areas
ID: 318950652