The renal handling of sodium and water is not affected by the standard-dose cisplatin treatment for testicular cancer.

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Renal clearances of 51Cr-EDTA, lithium, sodium and potassium were measured before and after each of four consecutive treatment series with cisplatin in 15 men with testicular cancer. Since lithium is reabsorbed like sodium and water in the proximal tubules, but not reabsorbed to any measurable degree in the remainder of the nephron, lithium clearance equals the amount of fluid delivered from the end of the proximal straight segment to the thin descending limb of the loop of Henle. From the clearances of lithium and sodium, distal tubular reabsorption can be calculated. Lithium clearance and all other parameters of glomerular filtration and renal sodium handling remained normal throughout the study (with the exception of a fall in fractional sodium excretion after the first treatment series). Plasma magnesium declined during all four treatment periods, signifying renal magnesium wasting.
Original languageEnglish
JournalScandinavian Journal of Clinical & Laboratory Investigation
Volume47
Issue number5
Pages (from-to)455-9
Number of pages4
ISSN0036-5513
Publication statusPublished - 1987

Bibliographical note

Keywords: Adult; Aged; Body Water; Chromium Radioisotopes; Cisplatin; Edetic Acid; Glomerular Filtration Rate; Humans; Kidney; Lithium; Magnesium; Male; Middle Aged; Sodium; Testicular Neoplasms

ID: 8440183