The inner ear produces a natriuretic hormone.
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The inner ear produces a natriuretic hormone. / Qvortrup, K; Rostgaard, J; Holstein-Rathlou, N H.
In: American Journal of Physiology (Consolidated), Vol. 270, No. 6 Pt 2, 1996, p. F1073-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The inner ear produces a natriuretic hormone.
AU - Qvortrup, K
AU - Rostgaard, J
AU - Holstein-Rathlou, N H
N1 - Keywords: Absorption; Animals; Blood Pressure; Diuresis; Ear, Inner; Endolymphatic Sac; Injections, Intravenous; Kidney Tubules, Proximal; Lithium; Male; Microscopy, Electron; Natriuresis; Natriuretic Agents; Potassium; Rats; Rats, Wistar; Sodium; Tissue Extracts
PY - 1996
Y1 - 1996
N2 - Cytoplasmic granules have been demonstrated in epithelial cells from the endolymphatic sac, an extraosseus part of the inner ear located in the posterior cranial fossa. Intravenously infused extracts from endolymphatic sacs in anesthetized rats elicited a potent natriuresis and diuresis without effects on blood pressure, glomerular filtration rate, or lithium clearance. Only a minor kaliuresis was observed. Extracts of dural tissue adjacent to the endolymphatic sacs had no effect. It is concluded that the endolymphatic sac contains as endogenous inhibitor of sodium reabsorption and could be the sensory organ/mediator of "cerebral" natriuresis. Furthermore, this substance, tentatively named saccin, may influence the homeostasis of the inner ear fluids and accordingly play a significant role in the pathogenesis of Mèniére's disease.
AB - Cytoplasmic granules have been demonstrated in epithelial cells from the endolymphatic sac, an extraosseus part of the inner ear located in the posterior cranial fossa. Intravenously infused extracts from endolymphatic sacs in anesthetized rats elicited a potent natriuresis and diuresis without effects on blood pressure, glomerular filtration rate, or lithium clearance. Only a minor kaliuresis was observed. Extracts of dural tissue adjacent to the endolymphatic sacs had no effect. It is concluded that the endolymphatic sac contains as endogenous inhibitor of sodium reabsorption and could be the sensory organ/mediator of "cerebral" natriuresis. Furthermore, this substance, tentatively named saccin, may influence the homeostasis of the inner ear fluids and accordingly play a significant role in the pathogenesis of Mèniére's disease.
M3 - Journal article
C2 - 8764327
VL - 270
SP - F1073-7
JO - American Journal of Physiology - Cell Physiology
JF - American Journal of Physiology - Cell Physiology
SN - 0363-6143
IS - 6 Pt 2
ER -
ID: 8439616