The impact of cardiovascular risk factors on global longitudinal strain over a decade in the general population: the copenhagen city heart study
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The impact of cardiovascular risk factors on global longitudinal strain over a decade in the general population : the copenhagen city heart study. / Skaarup, Kristoffer Grundtvig; Lassen, Mats Christian Hojbjerg; Marott, Jacob Louis; Biering-Sorensen, Sofie R.; Jorgensen, Peter Godsk; Appleyard, Merete; Berning, Jens; Host, Nis; Jensen, Gorm; Schnohr, Peter; Sogaard, Peter; Gislason, Gunnar; Mogelvang, Rasmus; Biering-Sorensen, Tor.
In: International Journal of Cardiovascular Imaging, Vol. 36, 2020, p. 1907–1916.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The impact of cardiovascular risk factors on global longitudinal strain over a decade in the general population
T2 - the copenhagen city heart study
AU - Skaarup, Kristoffer Grundtvig
AU - Lassen, Mats Christian Hojbjerg
AU - Marott, Jacob Louis
AU - Biering-Sorensen, Sofie R.
AU - Jorgensen, Peter Godsk
AU - Appleyard, Merete
AU - Berning, Jens
AU - Host, Nis
AU - Jensen, Gorm
AU - Schnohr, Peter
AU - Sogaard, Peter
AU - Gislason, Gunnar
AU - Mogelvang, Rasmus
AU - Biering-Sorensen, Tor
PY - 2020
Y1 - 2020
N2 - Global longitudinal strain (GLS) declines throughout adult-life as the LV remodels and adapts. Information on the impact of cardiac risk factors such as male sex, obesity, smoking status, hypertension, hypercholesterolemia, and diabetes on GLS. over time has not yet been investigated. The present prospective longitudinal study included 689 participants of the 4th and 5th Copenhagen City Heart Study who had GLS measured at both timepoints. Mean age was 51 years and 45% were male. All participants underwent two echocardiographic examinations median 10.4 (IQR: 10.2, 10.9) years apart. Average decline in GLS during follow-up was -0.7%. High age, male sex, high body mass index, and mean arterial blood pressure (MAP) proved to be significantly associated with an accelerated decline in GLS. In a multivariable regression model including all the investigated cardiovascular risk factors, age (stand. beta-coef. = -0.10, P = 0.005), male sex (stand. beta-coef. = -0.16, P < 0.001), and MAP (stand. beta-coef. = -0.07, P = 0.009) were independent predictors of an accelerated decline in GLS during a 10-year period. Finally, the investigated risk factors had different regional impact after the same multivariable adjustments. Male sex had a significant impact on changes in longitudinal strain at the apical, mid-wall and basal segments, meanwhile MAP and age only accelerated changes in the mid-wall and basal longitudinal strain. In the general population age, male sex, and MAP are independent predictors of an accelerated decline in GLS over a 10-year period. Furthermore, MAP, male sex and age had different regional impact.
AB - Global longitudinal strain (GLS) declines throughout adult-life as the LV remodels and adapts. Information on the impact of cardiac risk factors such as male sex, obesity, smoking status, hypertension, hypercholesterolemia, and diabetes on GLS. over time has not yet been investigated. The present prospective longitudinal study included 689 participants of the 4th and 5th Copenhagen City Heart Study who had GLS measured at both timepoints. Mean age was 51 years and 45% were male. All participants underwent two echocardiographic examinations median 10.4 (IQR: 10.2, 10.9) years apart. Average decline in GLS during follow-up was -0.7%. High age, male sex, high body mass index, and mean arterial blood pressure (MAP) proved to be significantly associated with an accelerated decline in GLS. In a multivariable regression model including all the investigated cardiovascular risk factors, age (stand. beta-coef. = -0.10, P = 0.005), male sex (stand. beta-coef. = -0.16, P < 0.001), and MAP (stand. beta-coef. = -0.07, P = 0.009) were independent predictors of an accelerated decline in GLS during a 10-year period. Finally, the investigated risk factors had different regional impact after the same multivariable adjustments. Male sex had a significant impact on changes in longitudinal strain at the apical, mid-wall and basal segments, meanwhile MAP and age only accelerated changes in the mid-wall and basal longitudinal strain. In the general population age, male sex, and MAP are independent predictors of an accelerated decline in GLS over a 10-year period. Furthermore, MAP, male sex and age had different regional impact.
KW - General population
KW - Echocardiography
KW - Global longitudinal strain
KW - Risk factors
U2 - 10.1007/s10554-020-01906-5
DO - 10.1007/s10554-020-01906-5
M3 - Journal article
C2 - 32507994
VL - 36
SP - 1907
EP - 1916
JO - International Journal of Cardiovascular Imaging
JF - International Journal of Cardiovascular Imaging
SN - 1569-5794
ER -
ID: 244380212