The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism
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Leptin regulates body weight by its receptor-mediated anorectic, thermogenic and antisteatotic effects. Recently, lower leptin binding to the soluble form of the leptin receptor (LEPR) was shown in carriers of the Arg223-encoding allele of the Gln223Arg polymorphism of the LEPR. To investigate whether this variant influences energy metabolism and adiposity in Pima Indians, we genotyped non-diabetic Pima Indians in whom we had measured body composition and 24 h energy expenditure (24 h EE), physical activity level (PAL) and 24 h respiratory quotient (24 h RQ) in a respiratory chamber (n=268) and who had undergone percutaneous fat biopsies from the periumbilical region (n=184). Genotype was not associated with percent body fat (P>0.39), but was associated with 24 h EE, PAL and mean subcutaneous abdominal adipocyte size (SAAS all P
Original language | English |
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Journal | International Journal of Obesity |
Volume | 26 |
Issue number | 12 |
Pages (from-to) | 1629-32 |
Number of pages | 4 |
ISSN | 0307-0565 |
DOIs | |
Publication status | Published - 1 Dec 2002 |
- Adipocytes, Adult, Cell Size, Energy Metabolism, Female, Genotype, Homozygote, Humans, Indians, North American, Lipid Metabolism, Male, Motor Activity, Polymorphism, Genetic, Receptors, Cell Surface, Receptors, Leptin
Research areas
ID: 33926888