The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism

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The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism. / Stefan, N; Vozarova, B; Del Parigi, A; Ossowski, V; Thompson, D B; Hanson, R L; Ravussin, E; Tataranni, P A; de Courten, Barbora.

In: International Journal of Obesity, Vol. 26, No. 12, 01.12.2002, p. 1629-32.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Stefan, N, Vozarova, B, Del Parigi, A, Ossowski, V, Thompson, DB, Hanson, RL, Ravussin, E, Tataranni, PA & de Courten, B 2002, 'The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism', International Journal of Obesity, vol. 26, no. 12, pp. 1629-32. https://doi.org/10.1038/sj.ijo.0802161

APA

Stefan, N., Vozarova, B., Del Parigi, A., Ossowski, V., Thompson, D. B., Hanson, R. L., Ravussin, E., Tataranni, P. A., & de Courten, B. (2002). The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism. International Journal of Obesity, 26(12), 1629-32. https://doi.org/10.1038/sj.ijo.0802161

Vancouver

Stefan N, Vozarova B, Del Parigi A, Ossowski V, Thompson DB, Hanson RL et al. The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism. International Journal of Obesity. 2002 Dec 1;26(12):1629-32. https://doi.org/10.1038/sj.ijo.0802161

Author

Stefan, N ; Vozarova, B ; Del Parigi, A ; Ossowski, V ; Thompson, D B ; Hanson, R L ; Ravussin, E ; Tataranni, P A ; de Courten, Barbora. / The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism. In: International Journal of Obesity. 2002 ; Vol. 26, No. 12. pp. 1629-32.

Bibtex

@article{fa48bad4ecdb4ef6a32971b42b0c5c8a,
title = "The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism",
abstract = "Leptin regulates body weight by its receptor-mediated anorectic, thermogenic and antisteatotic effects. Recently, lower leptin binding to the soluble form of the leptin receptor (LEPR) was shown in carriers of the Arg223-encoding allele of the Gln223Arg polymorphism of the LEPR. To investigate whether this variant influences energy metabolism and adiposity in Pima Indians, we genotyped non-diabetic Pima Indians in whom we had measured body composition and 24 h energy expenditure (24 h EE), physical activity level (PAL) and 24 h respiratory quotient (24 h RQ) in a respiratory chamber (n=268) and who had undergone percutaneous fat biopsies from the periumbilical region (n=184). Genotype was not associated with percent body fat (P>0.39), but was associated with 24 h EE, PAL and mean subcutaneous abdominal adipocyte size (SAAS all P",
keywords = "Adipocytes, Adult, Cell Size, Energy Metabolism, Female, Genotype, Homozygote, Humans, Indians, North American, Lipid Metabolism, Male, Motor Activity, Polymorphism, Genetic, Receptors, Cell Surface, Receptors, Leptin",
author = "N Stefan and B Vozarova and {Del Parigi}, A and V Ossowski and Thompson, {D B} and Hanson, {R L} and E Ravussin and Tataranni, {P A} and {de Courten}, Barbora",
year = "2002",
month = dec,
day = "1",
doi = "10.1038/sj.ijo.0802161",
language = "English",
volume = "26",
pages = "1629--32",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "nature publishing group",
number = "12",

}

RIS

TY - JOUR

T1 - The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism

AU - Stefan, N

AU - Vozarova, B

AU - Del Parigi, A

AU - Ossowski, V

AU - Thompson, D B

AU - Hanson, R L

AU - Ravussin, E

AU - Tataranni, P A

AU - de Courten, Barbora

PY - 2002/12/1

Y1 - 2002/12/1

N2 - Leptin regulates body weight by its receptor-mediated anorectic, thermogenic and antisteatotic effects. Recently, lower leptin binding to the soluble form of the leptin receptor (LEPR) was shown in carriers of the Arg223-encoding allele of the Gln223Arg polymorphism of the LEPR. To investigate whether this variant influences energy metabolism and adiposity in Pima Indians, we genotyped non-diabetic Pima Indians in whom we had measured body composition and 24 h energy expenditure (24 h EE), physical activity level (PAL) and 24 h respiratory quotient (24 h RQ) in a respiratory chamber (n=268) and who had undergone percutaneous fat biopsies from the periumbilical region (n=184). Genotype was not associated with percent body fat (P>0.39), but was associated with 24 h EE, PAL and mean subcutaneous abdominal adipocyte size (SAAS all P

AB - Leptin regulates body weight by its receptor-mediated anorectic, thermogenic and antisteatotic effects. Recently, lower leptin binding to the soluble form of the leptin receptor (LEPR) was shown in carriers of the Arg223-encoding allele of the Gln223Arg polymorphism of the LEPR. To investigate whether this variant influences energy metabolism and adiposity in Pima Indians, we genotyped non-diabetic Pima Indians in whom we had measured body composition and 24 h energy expenditure (24 h EE), physical activity level (PAL) and 24 h respiratory quotient (24 h RQ) in a respiratory chamber (n=268) and who had undergone percutaneous fat biopsies from the periumbilical region (n=184). Genotype was not associated with percent body fat (P>0.39), but was associated with 24 h EE, PAL and mean subcutaneous abdominal adipocyte size (SAAS all P

KW - Adipocytes

KW - Adult

KW - Cell Size

KW - Energy Metabolism

KW - Female

KW - Genotype

KW - Homozygote

KW - Humans

KW - Indians, North American

KW - Lipid Metabolism

KW - Male

KW - Motor Activity

KW - Polymorphism, Genetic

KW - Receptors, Cell Surface

KW - Receptors, Leptin

U2 - 10.1038/sj.ijo.0802161

DO - 10.1038/sj.ijo.0802161

M3 - Journal article

C2 - 12461680

VL - 26

SP - 1629

EP - 1632

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - 12

ER -

ID: 33926888