The extracellular matrix of the skin: systemic diseases with local manifestations
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The extracellular matrix of the skin : systemic diseases with local manifestations. / Port, H.; Groen, S. S.; Karsdal, M. A.; Holm Nielsen, S.
Biochemistry of Collagens, Laminins and Elastin: Structure, Function and Biomarkers. 3. ed. Elsevier, 2024. p. 459-472.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - The extracellular matrix of the skin
T2 - systemic diseases with local manifestations
AU - Port, H.
AU - Groen, S. S.
AU - Karsdal, M. A.
AU - Holm Nielsen, S.
N1 - Publisher Copyright: © 2024 Elsevier Inc. All rights reserved.
PY - 2024
Y1 - 2024
N2 - The skin is the largest organ of the body and the first barrier to protect the organism against the external environment. The skin is organized in three layers: epidermis, dermis, and hypodermis. The largest component of skin is the extracellular matrix (ECM), which is composed of collagens, elastin fibers, glycoproteins, and matricellular proteins found in the epidermis and dermis. The ECM plays an important role in regulating and ensuring skin homeostasis; however, deregulation in ECM composition contributes to the development of skin diseases. The most common skin diseases are atopic dermatitis, hidradenitis suppurativa, psoriasis, urticaria, vitiligo, and alopecia, while less common examples are prurigo nodularis, scleroderma, and systemic lupus erythematosus. ECM biomarkers have been associated with the severity and activity of different skin diseases and may be valuable for diagnostic and prognostic purposes.
AB - The skin is the largest organ of the body and the first barrier to protect the organism against the external environment. The skin is organized in three layers: epidermis, dermis, and hypodermis. The largest component of skin is the extracellular matrix (ECM), which is composed of collagens, elastin fibers, glycoproteins, and matricellular proteins found in the epidermis and dermis. The ECM plays an important role in regulating and ensuring skin homeostasis; however, deregulation in ECM composition contributes to the development of skin diseases. The most common skin diseases are atopic dermatitis, hidradenitis suppurativa, psoriasis, urticaria, vitiligo, and alopecia, while less common examples are prurigo nodularis, scleroderma, and systemic lupus erythematosus. ECM biomarkers have been associated with the severity and activity of different skin diseases and may be valuable for diagnostic and prognostic purposes.
KW - Atopic dermatitis
KW - Hidradenitis suppurativa
KW - Psoriasis
KW - Skin
KW - Urticaria
KW - Vitiligo
U2 - 10.1016/B978-0-443-15617-5.00013-5
DO - 10.1016/B978-0-443-15617-5.00013-5
M3 - Book chapter
AN - SCOPUS:85184099717
SN - 9780443156182
SP - 459
EP - 472
BT - Biochemistry of Collagens, Laminins and Elastin
PB - Elsevier
ER -
ID: 391159199