The effect of kidney transplantation on left ventricular remodeling and global diastolic strain rate in end-stage renal disease
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The effect of kidney transplantation on left ventricular remodeling and global diastolic strain rate in end-stage renal disease. / Lassen, Mats Christian Højbjerg; Qasim, Atif; Webber, Allison; Gao, Ying; Biering-Sørensen, Tor; Park, Meyeon.
In: Echocardiography, Vol. 38, No. 11, 2021, p. 1879-1886.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The effect of kidney transplantation on left ventricular remodeling and global diastolic strain rate in end-stage renal disease
AU - Lassen, Mats Christian Højbjerg
AU - Qasim, Atif
AU - Webber, Allison
AU - Gao, Ying
AU - Biering-Sørensen, Tor
AU - Park, Meyeon
N1 - Publisher Copyright: © 2021 Wiley Periodicals LLC
PY - 2021
Y1 - 2021
N2 - Background: Diastolic dysfunction is an early marker of cardiac pathology in end-stage kidney disease (ESKD) patients. The ratio of transmitral filling velocity (E) to early diastolic strain rate (E/e'sr) is a novel non-invasive marker of early left ventricular (LV) filling pressure obtained using two-dimensional speckle tracking echocardiography (2DSTE). Methods: In a prospective cohort of kidney transplant (KTX) recipients with echocardiograms performed pre-transplant we obtained repeat echocardiograms at 6 months following transplant. All echocardiograms were analyzed using 2DSTE where E/e'sr and global longitudinal strain were obtained. Paired tests were used to assess changes to cardiac structure and function following KTX. Results: A total of 33 patients were included in the study (mean age was 46.6 ± 13.7 years and 42% were males). The primary causes of ESKD in the cohort were glomerular disease (33%), hypertension (30%), and polycystic kidney disease (12%). The median (IQR) time spent on dialysis was 5.4 years [2.9, 7.7 years]. A reverse remodeling of the LV was observed following KTX as LV mass decreased (189.2 ± 57.5 g vs 171.1 ± 56.8 g, P = 0.014). LV filling pressure decreased as assessed by E/e'sr (103.7 ± 51.1 cm vs 72.6 ± 35.5 cm, P = 0.009). E to early diastolic mitral annular tissue velocity (E/e’) did not change following KTX (9.9 ± 4.5 vs 10.3 ± 4.1, P = 0.54). Additionally, both LV internal diastolic and systolic diameter decreased significantly. Conclusion: Reverse cardiac remodeling following KTX was observed as improvements in LV mass and LV dimensions. LV filling pressure improved as assessed by E/e'sr decreased following KTX, whereas E/e’ did not change.
AB - Background: Diastolic dysfunction is an early marker of cardiac pathology in end-stage kidney disease (ESKD) patients. The ratio of transmitral filling velocity (E) to early diastolic strain rate (E/e'sr) is a novel non-invasive marker of early left ventricular (LV) filling pressure obtained using two-dimensional speckle tracking echocardiography (2DSTE). Methods: In a prospective cohort of kidney transplant (KTX) recipients with echocardiograms performed pre-transplant we obtained repeat echocardiograms at 6 months following transplant. All echocardiograms were analyzed using 2DSTE where E/e'sr and global longitudinal strain were obtained. Paired tests were used to assess changes to cardiac structure and function following KTX. Results: A total of 33 patients were included in the study (mean age was 46.6 ± 13.7 years and 42% were males). The primary causes of ESKD in the cohort were glomerular disease (33%), hypertension (30%), and polycystic kidney disease (12%). The median (IQR) time spent on dialysis was 5.4 years [2.9, 7.7 years]. A reverse remodeling of the LV was observed following KTX as LV mass decreased (189.2 ± 57.5 g vs 171.1 ± 56.8 g, P = 0.014). LV filling pressure decreased as assessed by E/e'sr (103.7 ± 51.1 cm vs 72.6 ± 35.5 cm, P = 0.009). E to early diastolic mitral annular tissue velocity (E/e’) did not change following KTX (9.9 ± 4.5 vs 10.3 ± 4.1, P = 0.54). Additionally, both LV internal diastolic and systolic diameter decreased significantly. Conclusion: Reverse cardiac remodeling following KTX was observed as improvements in LV mass and LV dimensions. LV filling pressure improved as assessed by E/e'sr decreased following KTX, whereas E/e’ did not change.
KW - diastolic strain rate
KW - E/e'sr
KW - end-stage kidney disease
KW - kidney transplant
UR - http://www.scopus.com/inward/record.url?scp=85117928246&partnerID=8YFLogxK
U2 - 10.1111/echo.15226
DO - 10.1111/echo.15226
M3 - Journal article
C2 - 34713484
AN - SCOPUS:85117928246
VL - 38
SP - 1879
EP - 1886
JO - Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques
JF - Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques
SN - 0742-2822
IS - 11
ER -
ID: 286317146