The effect of feeding frequency on insulin and ghrelin responses in human subjects
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
The effect of feeding frequency on insulin and ghrelin responses in human subjects. / Solomon, Thomas; Chambers, Edward S; Jeukendrup, Asker E; Toogood, Andrew A; Blannin, Andrew K.
In: The British Journal of Nutrition, Vol. 100, No. 4, 10.2008, p. 810-9.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - The effect of feeding frequency on insulin and ghrelin responses in human subjects
AU - Solomon, Thomas
AU - Chambers, Edward S
AU - Jeukendrup, Asker E
AU - Toogood, Andrew A
AU - Blannin, Andrew K
PY - 2008/10
Y1 - 2008/10
N2 - Recent work shows that increased meal frequency reduces ghrelin responses in sheep. Human research suggests there is an interaction between insulin and ghrelin. The effect of meal frequency on this interaction is unknown. Therefore, we investigated the effect of feeding frequency on insulin and ghrelin responses in human subjects. Five healthy male volunteers were recruited from the general population: age 24 (SEM 2)years, body mass 75.7 (SEM 3.2) kg and BMI 23.8 (SEM 0.8) kg/m(2). Volunteers underwent three 8-h feeding regimens: fasting (FAST); low-frequency(two) meal ingestion (LOFREQ(MEAL)); high-frequency (twelve) meal ingestion (HIFREQ(MEAL)). Meals were equi-energetic within trials,consisting of 64% carbohydrate, 23% fat and 13% protein. Total energy intake was equal between feeding trials. Total area under the curve for serum insulin and plasma ghrelin responses did not differ between trials (P>0.05), although the hormonal response patterns to the two meal feeding regimens were different. An inverse relationship was found between serum insulin and plasma ghrelin during the FAST andLOFREQ(MEAL) trials (P0.05). This study provides further evidence that the postprandial fall in ghrelin might be due, at least partially, to the rise in insulin and that high-frequency feeding may disrupt this relationship.
AB - Recent work shows that increased meal frequency reduces ghrelin responses in sheep. Human research suggests there is an interaction between insulin and ghrelin. The effect of meal frequency on this interaction is unknown. Therefore, we investigated the effect of feeding frequency on insulin and ghrelin responses in human subjects. Five healthy male volunteers were recruited from the general population: age 24 (SEM 2)years, body mass 75.7 (SEM 3.2) kg and BMI 23.8 (SEM 0.8) kg/m(2). Volunteers underwent three 8-h feeding regimens: fasting (FAST); low-frequency(two) meal ingestion (LOFREQ(MEAL)); high-frequency (twelve) meal ingestion (HIFREQ(MEAL)). Meals were equi-energetic within trials,consisting of 64% carbohydrate, 23% fat and 13% protein. Total energy intake was equal between feeding trials. Total area under the curve for serum insulin and plasma ghrelin responses did not differ between trials (P>0.05), although the hormonal response patterns to the two meal feeding regimens were different. An inverse relationship was found between serum insulin and plasma ghrelin during the FAST andLOFREQ(MEAL) trials (P0.05). This study provides further evidence that the postprandial fall in ghrelin might be due, at least partially, to the rise in insulin and that high-frequency feeding may disrupt this relationship.
KW - Adult
KW - Analysis of Variance
KW - Area Under Curve
KW - Blood Glucose
KW - Cross-Over Studies
KW - Feeding Behavior
KW - Ghrelin
KW - Humans
KW - Insulin
KW - Male
KW - Postprandial Period
KW - Time Factors
KW - Young Adult
U2 - 10.1017/S000711450896757X
DO - 10.1017/S000711450896757X
M3 - Journal article
C2 - 18394217
VL - 100
SP - 810
EP - 819
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
IS - 4
ER -
ID: 50218548