The association between alcohol consumption and contact sensitization in Danish adults: the Glostrup Allergy Study
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The association between alcohol consumption and contact sensitization in Danish adults: the Glostrup Allergy Study. / Thyssen, Jacob Pontoppidan; Nielsen, N.H.; Linneberg, A.
In: British Journal of Dermatology, Vol. 158, No. 2, 2008, p. 306-312.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The association between alcohol consumption and contact sensitization in Danish adults: the Glostrup Allergy Study
AU - Thyssen, Jacob Pontoppidan
AU - Nielsen, N.H.
AU - Linneberg, A.
N1 - Times Cited: 0ArticleEnglishThyssen, J. PGentofte Univ Hosp, Dept Dermatol, Natl Allergy Res Ctr, Ledreborg Alle 10 1, DK-2820 Gentofte, DenmarkCited References Count: 52253BZBLACKWELL PUBLISHING9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLANDOXFORD
PY - 2008
Y1 - 2008
N2 - Background Population-based epidemiological studies have indicated that alcohol consumption is associated with IgE-mediated immune diseases (i.e. allergic rhinitis, asthma and urticaria). These studies have been strongly supported by several immunological studies. Furthermore, an inhibitory effect of alcohol consumption on the development of delayed-type hypersensitivity has been shown in healthy controls. However, a possible association between contact sensitization and alcohol consumption in a general population has never been reported. Objectives To investigate whether alcohol consumption is associated with contact sensitization in a general population. Methods In 1990, self-reported consumption of alcohol and patch testing results were assessed in 1112 subjects, aged 15-69 years, participating in a population-based cross-sectional study in Glostrup, Denmark. In 1998, they were invited to a follow-up and 734 were re-examined (participation rate 69.0%). Adjustment for potential confounders was performed by using logistic regression analyses. Results Women who reported no consumption of alcoholic drinks per week were more likely to develop contact sensitization (adjusted odds ratio 2.12, 95% confidence interval 0.98-4.61) during a 8-year follow-up period. A positive trend among women was detected (P = 0.045). Conclusions These data support the hypothesis that alcohol consumption leads to IgE-mediated immune responses rather than delayed-type hypersensitivity reactions. It is probable that alcohol consumption prevents the development of contact sensitization. Further epidemiological studies are warranted Udgivelsesdato: 2008/2
AB - Background Population-based epidemiological studies have indicated that alcohol consumption is associated with IgE-mediated immune diseases (i.e. allergic rhinitis, asthma and urticaria). These studies have been strongly supported by several immunological studies. Furthermore, an inhibitory effect of alcohol consumption on the development of delayed-type hypersensitivity has been shown in healthy controls. However, a possible association between contact sensitization and alcohol consumption in a general population has never been reported. Objectives To investigate whether alcohol consumption is associated with contact sensitization in a general population. Methods In 1990, self-reported consumption of alcohol and patch testing results were assessed in 1112 subjects, aged 15-69 years, participating in a population-based cross-sectional study in Glostrup, Denmark. In 1998, they were invited to a follow-up and 734 were re-examined (participation rate 69.0%). Adjustment for potential confounders was performed by using logistic regression analyses. Results Women who reported no consumption of alcoholic drinks per week were more likely to develop contact sensitization (adjusted odds ratio 2.12, 95% confidence interval 0.98-4.61) during a 8-year follow-up period. A positive trend among women was detected (P = 0.045). Conclusions These data support the hypothesis that alcohol consumption leads to IgE-mediated immune responses rather than delayed-type hypersensitivity reactions. It is probable that alcohol consumption prevents the development of contact sensitization. Further epidemiological studies are warranted Udgivelsesdato: 2008/2
U2 - 10.1111/j.1365-2133.2007.08336.x
DO - 10.1111/j.1365-2133.2007.08336.x
M3 - Journal article
C2 - 18067484
VL - 158
SP - 306
EP - 312
JO - British Journal of Dermatology
JF - British Journal of Dermatology
SN - 0007-0963
IS - 2
ER -
ID: 10449975