Terlipressin improves renal function in patients with cirrhosis and ascites without hepatorenal syndrome

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Standard

Terlipressin improves renal function in patients with cirrhosis and ascites without hepatorenal syndrome. / Krag, Aleksander; Møller, Søren; Henriksen, Jens H; von Holstein-Rathlou, Niels-Henrik; Larsen, Fin Stolze; Bendtsen, Flemming.

In: Hepatology, Vol. 46, No. 6, 2007, p. 1863-71.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Krag, A, Møller, S, Henriksen, JH, von Holstein-Rathlou, N-H, Larsen, FS & Bendtsen, F 2007, 'Terlipressin improves renal function in patients with cirrhosis and ascites without hepatorenal syndrome', Hepatology, vol. 46, no. 6, pp. 1863-71. https://doi.org/10.1002/hep.21901

APA

Krag, A., Møller, S., Henriksen, J. H., von Holstein-Rathlou, N-H., Larsen, F. S., & Bendtsen, F. (2007). Terlipressin improves renal function in patients with cirrhosis and ascites without hepatorenal syndrome. Hepatology, 46(6), 1863-71. https://doi.org/10.1002/hep.21901

Vancouver

Krag A, Møller S, Henriksen JH, von Holstein-Rathlou N-H, Larsen FS, Bendtsen F. Terlipressin improves renal function in patients with cirrhosis and ascites without hepatorenal syndrome. Hepatology. 2007;46(6):1863-71. https://doi.org/10.1002/hep.21901

Author

Krag, Aleksander ; Møller, Søren ; Henriksen, Jens H ; von Holstein-Rathlou, Niels-Henrik ; Larsen, Fin Stolze ; Bendtsen, Flemming. / Terlipressin improves renal function in patients with cirrhosis and ascites without hepatorenal syndrome. In: Hepatology. 2007 ; Vol. 46, No. 6. pp. 1863-71.

Bibtex

@article{8027f240ab5e11ddb5e9000ea68e967b,
title = "Terlipressin improves renal function in patients with cirrhosis and ascites without hepatorenal syndrome",
abstract = "Patients with advanced cirrhosis and ascites are characterized by circulatory dysfunction with splanchnic vasodilatation and renal vasoconstriction, which often lead to ascites. The vasoconstrictor terlipressin improves renal function in hepatorenal syndrome (HRS). The aim of this study was to evaluate if terlipressin also improves renal function in patients with ascites without HRS. Twenty-three patients with cirrhosis participated; 15 with nonrefractory ascites were randomized to either terlipressin (N group, n = 11) or a placebo (P group, n = 4), and 8 had refractory ascites and received terlipressin (R group). The glomerular filtration rate (GFR), sodium clearance (C(Na)), lithium clearance (C(Li)), osmolal clearance (C(Osm)), and urine sodium concentration (U(Na)) were assessed before and after the injection of 2 mg of terlipressin or the placebo. GFR increased in the N group (69 +/- 19 versus 92 +/- 25 mL/min, P < 0.005) and in the R group (31 +/- 19 versus 41 +/- 31 mL/min, P < 0.05) after terlipressin. In the N group, terlipressin induced an increase in C(Na) (0.89 +/- 0.21 versus 1.52 +/- 1.45 mL/min, P < 0.05), C(Li) (17.3 +/- 8.9 versus 21.5 +/- 11.6 mL/min, P < 0.05), and C(Osm) (2.10 +/- 0.81 versus 3.06 +/- 2.0 mL/min, P < 0.05). In the R group, terlipressin induced an increase in C(Na) (0.11 +/- 0.18 versus 0.35 +/- 0.40 mL/min, P < 0.05) and C(Li) (5.5 +/- 4.2 versus 9.5 +/- 8.55 mL/min, P < 0.05). U(Na) increased in both groups after terlipressin (P < 0.005). Plasma norepinephrine (P < 0.05) and renin (P < 0.05) decreased after terlipressin. All parameters remained unchanged after the placebo. Conclusion: The vasopressin 1 receptor agonist terlipressin improves renal function and induces natriuresis in patients with cirrhosis and ascites without HRS. Vasoconstrictors may represent a novel future treatment modality for these patients.",
author = "Aleksander Krag and S{\o}ren M{\o}ller and Henriksen, {Jens H} and {von Holstein-Rathlou}, Niels-Henrik and Larsen, {Fin Stolze} and Flemming Bendtsen",
note = "Keywords: Ascites; Double-Blind Method; Female; Glomerular Filtration Rate; Hepatorenal Syndrome; Humans; Kidney; Kidney Diseases; Liver Cirrhosis, Alcoholic; Lysine Vasopressin; Male; Middle Aged; Receptors, Vasopressin; Recovery of Function; Vasoconstrictor Agents",
year = "2007",
doi = "10.1002/hep.21901",
language = "English",
volume = "46",
pages = "1863--71",
journal = "Hepatology",
issn = "0270-9139",
publisher = "JohnWiley & Sons, Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Terlipressin improves renal function in patients with cirrhosis and ascites without hepatorenal syndrome

AU - Krag, Aleksander

AU - Møller, Søren

AU - Henriksen, Jens H

AU - von Holstein-Rathlou, Niels-Henrik

AU - Larsen, Fin Stolze

AU - Bendtsen, Flemming

N1 - Keywords: Ascites; Double-Blind Method; Female; Glomerular Filtration Rate; Hepatorenal Syndrome; Humans; Kidney; Kidney Diseases; Liver Cirrhosis, Alcoholic; Lysine Vasopressin; Male; Middle Aged; Receptors, Vasopressin; Recovery of Function; Vasoconstrictor Agents

PY - 2007

Y1 - 2007

N2 - Patients with advanced cirrhosis and ascites are characterized by circulatory dysfunction with splanchnic vasodilatation and renal vasoconstriction, which often lead to ascites. The vasoconstrictor terlipressin improves renal function in hepatorenal syndrome (HRS). The aim of this study was to evaluate if terlipressin also improves renal function in patients with ascites without HRS. Twenty-three patients with cirrhosis participated; 15 with nonrefractory ascites were randomized to either terlipressin (N group, n = 11) or a placebo (P group, n = 4), and 8 had refractory ascites and received terlipressin (R group). The glomerular filtration rate (GFR), sodium clearance (C(Na)), lithium clearance (C(Li)), osmolal clearance (C(Osm)), and urine sodium concentration (U(Na)) were assessed before and after the injection of 2 mg of terlipressin or the placebo. GFR increased in the N group (69 +/- 19 versus 92 +/- 25 mL/min, P < 0.005) and in the R group (31 +/- 19 versus 41 +/- 31 mL/min, P < 0.05) after terlipressin. In the N group, terlipressin induced an increase in C(Na) (0.89 +/- 0.21 versus 1.52 +/- 1.45 mL/min, P < 0.05), C(Li) (17.3 +/- 8.9 versus 21.5 +/- 11.6 mL/min, P < 0.05), and C(Osm) (2.10 +/- 0.81 versus 3.06 +/- 2.0 mL/min, P < 0.05). In the R group, terlipressin induced an increase in C(Na) (0.11 +/- 0.18 versus 0.35 +/- 0.40 mL/min, P < 0.05) and C(Li) (5.5 +/- 4.2 versus 9.5 +/- 8.55 mL/min, P < 0.05). U(Na) increased in both groups after terlipressin (P < 0.005). Plasma norepinephrine (P < 0.05) and renin (P < 0.05) decreased after terlipressin. All parameters remained unchanged after the placebo. Conclusion: The vasopressin 1 receptor agonist terlipressin improves renal function and induces natriuresis in patients with cirrhosis and ascites without HRS. Vasoconstrictors may represent a novel future treatment modality for these patients.

AB - Patients with advanced cirrhosis and ascites are characterized by circulatory dysfunction with splanchnic vasodilatation and renal vasoconstriction, which often lead to ascites. The vasoconstrictor terlipressin improves renal function in hepatorenal syndrome (HRS). The aim of this study was to evaluate if terlipressin also improves renal function in patients with ascites without HRS. Twenty-three patients with cirrhosis participated; 15 with nonrefractory ascites were randomized to either terlipressin (N group, n = 11) or a placebo (P group, n = 4), and 8 had refractory ascites and received terlipressin (R group). The glomerular filtration rate (GFR), sodium clearance (C(Na)), lithium clearance (C(Li)), osmolal clearance (C(Osm)), and urine sodium concentration (U(Na)) were assessed before and after the injection of 2 mg of terlipressin or the placebo. GFR increased in the N group (69 +/- 19 versus 92 +/- 25 mL/min, P < 0.005) and in the R group (31 +/- 19 versus 41 +/- 31 mL/min, P < 0.05) after terlipressin. In the N group, terlipressin induced an increase in C(Na) (0.89 +/- 0.21 versus 1.52 +/- 1.45 mL/min, P < 0.05), C(Li) (17.3 +/- 8.9 versus 21.5 +/- 11.6 mL/min, P < 0.05), and C(Osm) (2.10 +/- 0.81 versus 3.06 +/- 2.0 mL/min, P < 0.05). In the R group, terlipressin induced an increase in C(Na) (0.11 +/- 0.18 versus 0.35 +/- 0.40 mL/min, P < 0.05) and C(Li) (5.5 +/- 4.2 versus 9.5 +/- 8.55 mL/min, P < 0.05). U(Na) increased in both groups after terlipressin (P < 0.005). Plasma norepinephrine (P < 0.05) and renin (P < 0.05) decreased after terlipressin. All parameters remained unchanged after the placebo. Conclusion: The vasopressin 1 receptor agonist terlipressin improves renal function and induces natriuresis in patients with cirrhosis and ascites without HRS. Vasoconstrictors may represent a novel future treatment modality for these patients.

U2 - 10.1002/hep.21901

DO - 10.1002/hep.21901

M3 - Journal article

C2 - 18027874

VL - 46

SP - 1863

EP - 1871

JO - Hepatology

JF - Hepatology

SN - 0270-9139

IS - 6

ER -

ID: 8419786