Syndecans-2 and -4; close cousins, but not identical twins.

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Syndecans-2 and -4; close cousins, but not identical twins. / Oh, Eok-Soo; Couchman, John R.

In: Molecules and Cells, Vol. 17, No. 2, 2004, p. 181-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Oh, E-S & Couchman, JR 2004, 'Syndecans-2 and -4; close cousins, but not identical twins.', Molecules and Cells, vol. 17, no. 2, pp. 181-7.

APA

Oh, E-S., & Couchman, J. R. (2004). Syndecans-2 and -4; close cousins, but not identical twins. Molecules and Cells, 17(2), 181-7.

Vancouver

Oh E-S, Couchman JR. Syndecans-2 and -4; close cousins, but not identical twins. Molecules and Cells. 2004;17(2):181-7.

Author

Oh, Eok-Soo ; Couchman, John R. / Syndecans-2 and -4; close cousins, but not identical twins. In: Molecules and Cells. 2004 ; Vol. 17, No. 2. pp. 181-7.

Bibtex

@article{9de2daa0596211dd8d9f000ea68e967b,
title = "Syndecans-2 and -4; close cousins, but not identical twins.",
abstract = "The vertebrate syndecans, which make up a four-member family of small type I transmembrane heparan sulfate proteoglycans, constitute evolutionarily conserved family proteins. In particular, sequences in the transmembrane and cytoplasmic domains are a unifying feature within the family. However, the extracellular domain sequences are molecule-specific, implying that different syndecans have evolved to carry out similar, but non-identical, functions. While all four syndecans have been implicated in regulation of the cytoskeleton, their roles are clearly complex. Recent developments indicate that the closely related syndecan-2 and -4 have separable functions, though both bind a number of ligands through their heparan sulfate chains. The specification of these activities is probably core protein related, but is it due to a distinct expression pattern or molecule-specific regulatory mechanisms? Although there is not yet enough data to provide unambiguous answers, here we shall review the known functions and regulatory mechanisms of syndecan-2 and -4.",
author = "Eok-Soo Oh and Couchman, {John R}",
note = "Keywords: Animals; Cell Adhesion; Cell Division; Cytoskeleton; Growth Substances; Humans; Membrane Glycoproteins; Neovascularization, Physiologic; Protein Conformation; Proteoglycans; Syndecan-2; Syndecan-4; Tissue Distribution",
year = "2004",
language = "English",
volume = "17",
pages = "181--7",
journal = "Molecules and Cells",
issn = "1016-8478",
publisher = "Korean Society for Molecular Biology",
number = "2",

}

RIS

TY - JOUR

T1 - Syndecans-2 and -4; close cousins, but not identical twins.

AU - Oh, Eok-Soo

AU - Couchman, John R

N1 - Keywords: Animals; Cell Adhesion; Cell Division; Cytoskeleton; Growth Substances; Humans; Membrane Glycoproteins; Neovascularization, Physiologic; Protein Conformation; Proteoglycans; Syndecan-2; Syndecan-4; Tissue Distribution

PY - 2004

Y1 - 2004

N2 - The vertebrate syndecans, which make up a four-member family of small type I transmembrane heparan sulfate proteoglycans, constitute evolutionarily conserved family proteins. In particular, sequences in the transmembrane and cytoplasmic domains are a unifying feature within the family. However, the extracellular domain sequences are molecule-specific, implying that different syndecans have evolved to carry out similar, but non-identical, functions. While all four syndecans have been implicated in regulation of the cytoskeleton, their roles are clearly complex. Recent developments indicate that the closely related syndecan-2 and -4 have separable functions, though both bind a number of ligands through their heparan sulfate chains. The specification of these activities is probably core protein related, but is it due to a distinct expression pattern or molecule-specific regulatory mechanisms? Although there is not yet enough data to provide unambiguous answers, here we shall review the known functions and regulatory mechanisms of syndecan-2 and -4.

AB - The vertebrate syndecans, which make up a four-member family of small type I transmembrane heparan sulfate proteoglycans, constitute evolutionarily conserved family proteins. In particular, sequences in the transmembrane and cytoplasmic domains are a unifying feature within the family. However, the extracellular domain sequences are molecule-specific, implying that different syndecans have evolved to carry out similar, but non-identical, functions. While all four syndecans have been implicated in regulation of the cytoskeleton, their roles are clearly complex. Recent developments indicate that the closely related syndecan-2 and -4 have separable functions, though both bind a number of ligands through their heparan sulfate chains. The specification of these activities is probably core protein related, but is it due to a distinct expression pattern or molecule-specific regulatory mechanisms? Although there is not yet enough data to provide unambiguous answers, here we shall review the known functions and regulatory mechanisms of syndecan-2 and -4.

M3 - Journal article

C2 - 15179029

VL - 17

SP - 181

EP - 187

JO - Molecules and Cells

JF - Molecules and Cells

SN - 1016-8478

IS - 2

ER -

ID: 5160964