Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis. / Vadodaria, Krishna C; Brakebusch, Cord; Suter, Ueli; Jessberger, Sebastian.

In: Journal of Neuroscience, Vol. 33, No. 3, 16.01.2013, p. 1179-89.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Vadodaria, KC, Brakebusch, C, Suter, U & Jessberger, S 2013, 'Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis', Journal of Neuroscience, vol. 33, no. 3, pp. 1179-89. https://doi.org/10.1523/JNEUROSCI.2103-12.2013

APA

Vadodaria, K. C., Brakebusch, C., Suter, U., & Jessberger, S. (2013). Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis. Journal of Neuroscience, 33(3), 1179-89. https://doi.org/10.1523/JNEUROSCI.2103-12.2013

Vancouver

Vadodaria KC, Brakebusch C, Suter U, Jessberger S. Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis. Journal of Neuroscience. 2013 Jan 16;33(3):1179-89. https://doi.org/10.1523/JNEUROSCI.2103-12.2013

Author

Vadodaria, Krishna C ; Brakebusch, Cord ; Suter, Ueli ; Jessberger, Sebastian. / Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis. In: Journal of Neuroscience. 2013 ; Vol. 33, No. 3. pp. 1179-89.

Bibtex

@article{c0ed9bac7ad148e8b36fe6fff782bfcf,
title = "Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis",
abstract = "The molecular mechanisms underlying the generation, maturation, and integration of new granule cells generated throughout life in the mammalian hippocampus remain poorly understood. Small Rho GTPases, such as Cdc42 and Rac1, have been implicated previously in neural stem/progenitor cell (NSPC) proliferation and neuronal maturation during embryonic development. Here we used conditional genetic deletion and virus-based loss-of-function approaches to identify temporally distinct functions for Cdc42 and Rac1 in adult hippocampal neurogenesis. We found that Cdc42 is involved in mouse NSPC proliferation, initial dendritic development, and dendritic spine maturation. In contrast, Rac1 is dispensable for early steps of neuronal development but is important for late steps of dendritic growth and spine maturation. These results establish cell-autonomous and stage-specific functions for the small Rho GTPases Cdc42 and Rac1 in the course of adult hippocampal neurogenesis.",
keywords = "Animals, Cell Lineage, Cell Movement, Cell Proliferation, Dendrites, Dendritic Spines, Female, Hippocampus, Mice, Mice, Transgenic, Neurogenesis, Neurons, Rats, Rats, Inbred F344, cdc42 GTP-Binding Protein, rac1 GTP-Binding Protein",
author = "Vadodaria, {Krishna C} and Cord Brakebusch and Ueli Suter and Sebastian Jessberger",
year = "2013",
month = jan,
day = "16",
doi = "10.1523/JNEUROSCI.2103-12.2013",
language = "English",
volume = "33",
pages = "1179--89",
journal = "The Journal of neuroscience : the official journal of the Society for Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "3",

}

RIS

TY - JOUR

T1 - Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis

AU - Vadodaria, Krishna C

AU - Brakebusch, Cord

AU - Suter, Ueli

AU - Jessberger, Sebastian

PY - 2013/1/16

Y1 - 2013/1/16

N2 - The molecular mechanisms underlying the generation, maturation, and integration of new granule cells generated throughout life in the mammalian hippocampus remain poorly understood. Small Rho GTPases, such as Cdc42 and Rac1, have been implicated previously in neural stem/progenitor cell (NSPC) proliferation and neuronal maturation during embryonic development. Here we used conditional genetic deletion and virus-based loss-of-function approaches to identify temporally distinct functions for Cdc42 and Rac1 in adult hippocampal neurogenesis. We found that Cdc42 is involved in mouse NSPC proliferation, initial dendritic development, and dendritic spine maturation. In contrast, Rac1 is dispensable for early steps of neuronal development but is important for late steps of dendritic growth and spine maturation. These results establish cell-autonomous and stage-specific functions for the small Rho GTPases Cdc42 and Rac1 in the course of adult hippocampal neurogenesis.

AB - The molecular mechanisms underlying the generation, maturation, and integration of new granule cells generated throughout life in the mammalian hippocampus remain poorly understood. Small Rho GTPases, such as Cdc42 and Rac1, have been implicated previously in neural stem/progenitor cell (NSPC) proliferation and neuronal maturation during embryonic development. Here we used conditional genetic deletion and virus-based loss-of-function approaches to identify temporally distinct functions for Cdc42 and Rac1 in adult hippocampal neurogenesis. We found that Cdc42 is involved in mouse NSPC proliferation, initial dendritic development, and dendritic spine maturation. In contrast, Rac1 is dispensable for early steps of neuronal development but is important for late steps of dendritic growth and spine maturation. These results establish cell-autonomous and stage-specific functions for the small Rho GTPases Cdc42 and Rac1 in the course of adult hippocampal neurogenesis.

KW - Animals

KW - Cell Lineage

KW - Cell Movement

KW - Cell Proliferation

KW - Dendrites

KW - Dendritic Spines

KW - Female

KW - Hippocampus

KW - Mice

KW - Mice, Transgenic

KW - Neurogenesis

KW - Neurons

KW - Rats

KW - Rats, Inbred F344

KW - cdc42 GTP-Binding Protein

KW - rac1 GTP-Binding Protein

U2 - 10.1523/JNEUROSCI.2103-12.2013

DO - 10.1523/JNEUROSCI.2103-12.2013

M3 - Journal article

C2 - 23325254

VL - 33

SP - 1179

EP - 1189

JO - The Journal of neuroscience : the official journal of the Society for Neuroscience

JF - The Journal of neuroscience : the official journal of the Society for Neuroscience

SN - 0270-6474

IS - 3

ER -

ID: 45824752