Small-molecule mimicry hunting strategy in the imperial cone snail, Conus imperialis
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Small-molecule mimicry hunting strategy in the imperial cone snail, Conus imperialis. / Torres, Joshua P; Lin, Zhenjian; Watkins, Maren; Salcedo, Paula Flórez; Baskin, Robert P; Elhabian, Shireen; Safavi-Hemami, Helena; Taylor, Dylan; Tun, Jortan; Concepcion, Gisela P; Saguil, Noel; Yanagihara, Angel A; Fang, Yixin; McArthur, Jeffrey R; Tae, Han-Shen; Finol-Urdaneta, Rocio K; Özpolat, B Duygu; Olivera, Baldomero M; Schmidt, Eric W.
In: Science Advances, Vol. 7, No. 11, eabf2704, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Small-molecule mimicry hunting strategy in the imperial cone snail, Conus imperialis
AU - Torres, Joshua P
AU - Lin, Zhenjian
AU - Watkins, Maren
AU - Salcedo, Paula Flórez
AU - Baskin, Robert P
AU - Elhabian, Shireen
AU - Safavi-Hemami, Helena
AU - Taylor, Dylan
AU - Tun, Jortan
AU - Concepcion, Gisela P
AU - Saguil, Noel
AU - Yanagihara, Angel A
AU - Fang, Yixin
AU - McArthur, Jeffrey R
AU - Tae, Han-Shen
AU - Finol-Urdaneta, Rocio K
AU - Özpolat, B Duygu
AU - Olivera, Baldomero M
AU - Schmidt, Eric W
N1 - Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
PY - 2021
Y1 - 2021
N2 - Venomous animals hunt using bioactive peptides, but relatively little is known about venom small molecules and the resulting complex hunting behaviors. Here, we explored the specialized metabolites from the venom of the worm-hunting cone snail, Conus imperialis Using the model polychaete worm Platynereis dumerilii, we demonstrate that C. imperialis venom contains small molecules that mimic natural polychaete mating pheromones, evoking the mating phenotype in worms. The specialized metabolites from different cone snails are species-specific and structurally diverse, suggesting that the cones may adopt many different prey-hunting strategies enabled by small molecules. Predators sometimes attract prey using the prey's own pheromones, in a strategy known as aggressive mimicry. Instead, C. imperialis uses metabolically stable mimics of those pheromones, indicating that, in biological mimicry, even the molecules themselves may be disguised, providing a twist on fake news in chemical ecology.
AB - Venomous animals hunt using bioactive peptides, but relatively little is known about venom small molecules and the resulting complex hunting behaviors. Here, we explored the specialized metabolites from the venom of the worm-hunting cone snail, Conus imperialis Using the model polychaete worm Platynereis dumerilii, we demonstrate that C. imperialis venom contains small molecules that mimic natural polychaete mating pheromones, evoking the mating phenotype in worms. The specialized metabolites from different cone snails are species-specific and structurally diverse, suggesting that the cones may adopt many different prey-hunting strategies enabled by small molecules. Predators sometimes attract prey using the prey's own pheromones, in a strategy known as aggressive mimicry. Instead, C. imperialis uses metabolically stable mimics of those pheromones, indicating that, in biological mimicry, even the molecules themselves may be disguised, providing a twist on fake news in chemical ecology.
U2 - 10.1126/sciadv.abf2704
DO - 10.1126/sciadv.abf2704
M3 - Journal article
C2 - 33712468
VL - 7
JO - Science advances
JF - Science advances
SN - 2375-2548
IS - 11
M1 - eabf2704
ER -
ID: 259043037