Small-molecule inhibition of inflammatory β-cell death
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Small-molecule inhibition of inflammatory β-cell death. / Lundh, Morten; Scully, S S; Mandrup-Poulsen, T; Wagner, B K.
In: Diabetes, Obesity and Metabolism Online, Vol. 15 , No. 3, 09.2013, p. 176-84.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Small-molecule inhibition of inflammatory β-cell death
AU - Lundh, Morten
AU - Scully, S S
AU - Mandrup-Poulsen, T
AU - Wagner, B K
N1 - © 2013 John Wiley & Sons Ltd.
PY - 2013/9
Y1 - 2013/9
N2 - With the worldwide increase in diabetes prevalence there is a pressing unmet need for novel antidiabetic therapies. Insufficient insulin production due to impaired β-cell function and apoptotic reduction of β-cell mass is a common denominator in the pathogenesis of diabetes. Current treatments are directed at improving insulin sensitivity, and stimulating insulin secretion or replacing the hormone, but do not target progressive apoptotic β-cell loss. Here we review the current development of small-molecule inhibitors designed to rescue β-cells from apoptosis. Several distinct classes of small molecules have been identified that protect β-cells from inflammatory, oxidative and/or metabolically induced apoptosis. Although none of these have yet reached the clinic, β-cell protective small molecules alone or in combination with current therapies provide exciting opportunities for the development of novel treatments for diabetes.
AB - With the worldwide increase in diabetes prevalence there is a pressing unmet need for novel antidiabetic therapies. Insufficient insulin production due to impaired β-cell function and apoptotic reduction of β-cell mass is a common denominator in the pathogenesis of diabetes. Current treatments are directed at improving insulin sensitivity, and stimulating insulin secretion or replacing the hormone, but do not target progressive apoptotic β-cell loss. Here we review the current development of small-molecule inhibitors designed to rescue β-cells from apoptosis. Several distinct classes of small molecules have been identified that protect β-cells from inflammatory, oxidative and/or metabolically induced apoptosis. Although none of these have yet reached the clinic, β-cell protective small molecules alone or in combination with current therapies provide exciting opportunities for the development of novel treatments for diabetes.
U2 - 10.1111/dom.12158
DO - 10.1111/dom.12158
M3 - Journal article
C2 - 24003935
VL - 15
SP - 176
EP - 184
JO - Diabetes, Obesity and Metabolism
JF - Diabetes, Obesity and Metabolism
SN - 1462-8902
IS - 3
ER -
ID: 77964060