Sleep arousal burden is associated with long-term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Sleep arousal burden is associated with long-term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women. / Shahrbabaki, Sobhan Salari; Linz, Dominik; Hartmann, Simon; Redline, Susan; Baumert, Mathias.

In: European Heart Journal, Vol. 42, No. 21, 2021, p. 2088-2099.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Shahrbabaki, SS, Linz, D, Hartmann, S, Redline, S & Baumert, M 2021, 'Sleep arousal burden is associated with long-term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women', European Heart Journal, vol. 42, no. 21, pp. 2088-2099. https://doi.org/10.1093/eurheartj/ehab151

APA

Shahrbabaki, S. S., Linz, D., Hartmann, S., Redline, S., & Baumert, M. (2021). Sleep arousal burden is associated with long-term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women. European Heart Journal, 42(21), 2088-2099. https://doi.org/10.1093/eurheartj/ehab151

Vancouver

Shahrbabaki SS, Linz D, Hartmann S, Redline S, Baumert M. Sleep arousal burden is associated with long-term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women. European Heart Journal. 2021;42(21):2088-2099. https://doi.org/10.1093/eurheartj/ehab151

Author

Shahrbabaki, Sobhan Salari ; Linz, Dominik ; Hartmann, Simon ; Redline, Susan ; Baumert, Mathias. / Sleep arousal burden is associated with long-term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women. In: European Heart Journal. 2021 ; Vol. 42, No. 21. pp. 2088-2099.

Bibtex

@article{0804003dfc74444cbe91e53bcbec450d,
title = "Sleep arousal burden is associated with long-term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women",
abstract = "Aims: To quantify the arousal burden (AB) across large cohort studies and determine its association with long-term cardiovascular (CV) and overall mortality in men and women.Methods and results: We measured the AB on overnight polysomnograms of 2782 men in the Osteoporotic Fractures in Men Study (MrOS) Sleep study, 424 women in the Study of Osteoporotic Fractures (SOF) and 2221 men and 2574 women in the Sleep Heart Health Study (SHHS). During 11.2 +/- 2.1 years of follow-up in MrOS, 665 men died, including 236 CV deaths. During 6.4 +/- 1.6 years of follow-up in SOF, 105 women died, including 47 CV deaths. During 10.7 +/- 3.1 years of follow-up in SHHS, 987 participants died, including 344 CV deaths. In women, multivariable Cox proportional hazard analysis adjusted for common confounders demonstrated that AB is associated with all-cause mortality [SOF: hazard ratio (HR) 1.58 (1.01-2.42), P = 0.038; SHHS-women: HR 1.21 (1.06-1.42), P = 0.012] and CV mortality [SOF: HR 2.17 (1.04-4.50), P = 0.037; SHHS-women: HR 1.60 (1.12-2.28), P = 0.009]. In men, the association between AB and all-cause mortality [MrOS: HR 1.11 (0.94-1.32), P = 0.261; SHHS-men: HR 1.31 (1.06-1.62), P = 0.011] and CV mortality [MrOS: HR 1.35 (1.02-1.79), P = 0.034; SHHS-men: HR 1.24 (0.86-1.79), P = 0.271] was less clear.Conclusions: Nocturnal AB is associated with long-term CV and all-cause mortality in women and to a lesser extent in men.[GRAPHICS]",
keywords = "Sleep, Arousal, Sleep fragmentation, Total sleep time, Cohort study, Cardiovascular mortality, All-cause mortality, RISK-FACTOR, DURATION, FRAGMENTATION, APNEA",
author = "Shahrbabaki, {Sobhan Salari} and Dominik Linz and Simon Hartmann and Susan Redline and Mathias Baumert",
year = "2021",
doi = "10.1093/eurheartj/ehab151",
language = "English",
volume = "42",
pages = "2088--2099",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "21",

}

RIS

TY - JOUR

T1 - Sleep arousal burden is associated with long-term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women

AU - Shahrbabaki, Sobhan Salari

AU - Linz, Dominik

AU - Hartmann, Simon

AU - Redline, Susan

AU - Baumert, Mathias

PY - 2021

Y1 - 2021

N2 - Aims: To quantify the arousal burden (AB) across large cohort studies and determine its association with long-term cardiovascular (CV) and overall mortality in men and women.Methods and results: We measured the AB on overnight polysomnograms of 2782 men in the Osteoporotic Fractures in Men Study (MrOS) Sleep study, 424 women in the Study of Osteoporotic Fractures (SOF) and 2221 men and 2574 women in the Sleep Heart Health Study (SHHS). During 11.2 +/- 2.1 years of follow-up in MrOS, 665 men died, including 236 CV deaths. During 6.4 +/- 1.6 years of follow-up in SOF, 105 women died, including 47 CV deaths. During 10.7 +/- 3.1 years of follow-up in SHHS, 987 participants died, including 344 CV deaths. In women, multivariable Cox proportional hazard analysis adjusted for common confounders demonstrated that AB is associated with all-cause mortality [SOF: hazard ratio (HR) 1.58 (1.01-2.42), P = 0.038; SHHS-women: HR 1.21 (1.06-1.42), P = 0.012] and CV mortality [SOF: HR 2.17 (1.04-4.50), P = 0.037; SHHS-women: HR 1.60 (1.12-2.28), P = 0.009]. In men, the association between AB and all-cause mortality [MrOS: HR 1.11 (0.94-1.32), P = 0.261; SHHS-men: HR 1.31 (1.06-1.62), P = 0.011] and CV mortality [MrOS: HR 1.35 (1.02-1.79), P = 0.034; SHHS-men: HR 1.24 (0.86-1.79), P = 0.271] was less clear.Conclusions: Nocturnal AB is associated with long-term CV and all-cause mortality in women and to a lesser extent in men.[GRAPHICS]

AB - Aims: To quantify the arousal burden (AB) across large cohort studies and determine its association with long-term cardiovascular (CV) and overall mortality in men and women.Methods and results: We measured the AB on overnight polysomnograms of 2782 men in the Osteoporotic Fractures in Men Study (MrOS) Sleep study, 424 women in the Study of Osteoporotic Fractures (SOF) and 2221 men and 2574 women in the Sleep Heart Health Study (SHHS). During 11.2 +/- 2.1 years of follow-up in MrOS, 665 men died, including 236 CV deaths. During 6.4 +/- 1.6 years of follow-up in SOF, 105 women died, including 47 CV deaths. During 10.7 +/- 3.1 years of follow-up in SHHS, 987 participants died, including 344 CV deaths. In women, multivariable Cox proportional hazard analysis adjusted for common confounders demonstrated that AB is associated with all-cause mortality [SOF: hazard ratio (HR) 1.58 (1.01-2.42), P = 0.038; SHHS-women: HR 1.21 (1.06-1.42), P = 0.012] and CV mortality [SOF: HR 2.17 (1.04-4.50), P = 0.037; SHHS-women: HR 1.60 (1.12-2.28), P = 0.009]. In men, the association between AB and all-cause mortality [MrOS: HR 1.11 (0.94-1.32), P = 0.261; SHHS-men: HR 1.31 (1.06-1.62), P = 0.011] and CV mortality [MrOS: HR 1.35 (1.02-1.79), P = 0.034; SHHS-men: HR 1.24 (0.86-1.79), P = 0.271] was less clear.Conclusions: Nocturnal AB is associated with long-term CV and all-cause mortality in women and to a lesser extent in men.[GRAPHICS]

KW - Sleep

KW - Arousal

KW - Sleep fragmentation

KW - Total sleep time

KW - Cohort study

KW - Cardiovascular mortality

KW - All-cause mortality

KW - RISK-FACTOR

KW - DURATION

KW - FRAGMENTATION

KW - APNEA

U2 - 10.1093/eurheartj/ehab151

DO - 10.1093/eurheartj/ehab151

M3 - Journal article

C2 - 33876221

VL - 42

SP - 2088

EP - 2099

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 21

ER -

ID: 274612891