Short- and long-term effects of endurance training in patients with mitochondrial myopathy

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Short- and long-term effects of endurance training in patients with mitochondrial myopathy. / Jeppesen, T D; Dunø, M; Schwartz, M; Krag, T; Rafiq, J; Wibrand, F; Vissing, J.

In: European Journal of Neurology, Vol. 16, No. 12, 2009, p. 1336-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jeppesen, TD, Dunø, M, Schwartz, M, Krag, T, Rafiq, J, Wibrand, F & Vissing, J 2009, 'Short- and long-term effects of endurance training in patients with mitochondrial myopathy', European Journal of Neurology, vol. 16, no. 12, pp. 1336-9. https://doi.org/10.1111/j.1468-1331.2009.02660.x

APA

Jeppesen, T. D., Dunø, M., Schwartz, M., Krag, T., Rafiq, J., Wibrand, F., & Vissing, J. (2009). Short- and long-term effects of endurance training in patients with mitochondrial myopathy. European Journal of Neurology, 16(12), 1336-9. https://doi.org/10.1111/j.1468-1331.2009.02660.x

Vancouver

Jeppesen TD, Dunø M, Schwartz M, Krag T, Rafiq J, Wibrand F et al. Short- and long-term effects of endurance training in patients with mitochondrial myopathy. European Journal of Neurology. 2009;16(12):1336-9. https://doi.org/10.1111/j.1468-1331.2009.02660.x

Author

Jeppesen, T D ; Dunø, M ; Schwartz, M ; Krag, T ; Rafiq, J ; Wibrand, F ; Vissing, J. / Short- and long-term effects of endurance training in patients with mitochondrial myopathy. In: European Journal of Neurology. 2009 ; Vol. 16, No. 12. pp. 1336-9.

Bibtex

@article{fe581540359c11df8ed1000ea68e967b,
title = "Short- and long-term effects of endurance training in patients with mitochondrial myopathy",
abstract = "BACKGROUND AND PURPOSE: It is unknown whether prolonged training is a safe treatment to alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations. METHODS: The effect of 3 and 12 months training and 3-12 months deconditioning was studied in four patients carrying different mtDNA mutations. RESULTS: Three-month moderate-intensity training increased oxidative capacity by 23%, which was sustained after 6-12 months of low-intensity training. Training and deconditioning did not induce adverse effects on clinical symptoms, muscle morphology and mtDNA mutation load in muscle. CONCLUSION: Long-term training effectively improves exercise capacity in patients with mitochondrial myopathy, and appears to be safe.",
author = "Jeppesen, {T D} and M Dun{\o} and M Schwartz and T Krag and J Rafiq and F Wibrand and J Vissing",
note = "Keywords: Exercise Therapy; Exercise Tolerance; Humans; Mitochondrial Myopathies; Muscle, Skeletal; Time",
year = "2009",
doi = "10.1111/j.1468-1331.2009.02660.x",
language = "English",
volume = "16",
pages = "1336--9",
journal = "European Journal of Neurology",
issn = "1351-5101",
publisher = "Wiley-Blackwell",
number = "12",

}

RIS

TY - JOUR

T1 - Short- and long-term effects of endurance training in patients with mitochondrial myopathy

AU - Jeppesen, T D

AU - Dunø, M

AU - Schwartz, M

AU - Krag, T

AU - Rafiq, J

AU - Wibrand, F

AU - Vissing, J

N1 - Keywords: Exercise Therapy; Exercise Tolerance; Humans; Mitochondrial Myopathies; Muscle, Skeletal; Time

PY - 2009

Y1 - 2009

N2 - BACKGROUND AND PURPOSE: It is unknown whether prolonged training is a safe treatment to alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations. METHODS: The effect of 3 and 12 months training and 3-12 months deconditioning was studied in four patients carrying different mtDNA mutations. RESULTS: Three-month moderate-intensity training increased oxidative capacity by 23%, which was sustained after 6-12 months of low-intensity training. Training and deconditioning did not induce adverse effects on clinical symptoms, muscle morphology and mtDNA mutation load in muscle. CONCLUSION: Long-term training effectively improves exercise capacity in patients with mitochondrial myopathy, and appears to be safe.

AB - BACKGROUND AND PURPOSE: It is unknown whether prolonged training is a safe treatment to alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations. METHODS: The effect of 3 and 12 months training and 3-12 months deconditioning was studied in four patients carrying different mtDNA mutations. RESULTS: Three-month moderate-intensity training increased oxidative capacity by 23%, which was sustained after 6-12 months of low-intensity training. Training and deconditioning did not induce adverse effects on clinical symptoms, muscle morphology and mtDNA mutation load in muscle. CONCLUSION: Long-term training effectively improves exercise capacity in patients with mitochondrial myopathy, and appears to be safe.

U2 - 10.1111/j.1468-1331.2009.02660.x

DO - 10.1111/j.1468-1331.2009.02660.x

M3 - Journal article

C2 - 19486129

VL - 16

SP - 1336

EP - 1339

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

IS - 12

ER -

ID: 18764095