TY - JOUR

T1 - Role of Weekday Variation on Glucose, Insulin, and Triglyceride

T2 - A Cross-Sectional Analysis From the Maastricht Study

AU - Clemmensen, Kim K. B.

AU - Koster, Annemarie

AU - Nielen, Johannes T. H.

AU - Dagnelie, Pieter C.

AU - Stehouwer, Coen D. A.

AU - Bosma, Hans

AU - Wesselius, Anke

AU - Færch, Kristine

AU - Eussen, Simone J. P. M.

PY - 2022

Y1 - 2022

N2 - Context: The timing of sleep, physical activity, and dietary intake show variation over the week, with different timings in the weekend compared to the weekdays, which may potentially lead to impaired glucose and lipid regulation on Mondays compared to other weekdays.Objective The aim of the study was to investigate differences in glucose metabolism and fasting triglyceride concentrations on Mondays compared to the rest of the week.Design, setting and participants This cross-sectional study is based on data from the Maastricht Study, including 6067 participants without known diabetes and 1568 previously diagnosed with type 2 diabetes.Main outcome measures Confounder-adjusted linear regression analysis was applied to study the associations of day of the week of examination with glucose and insulin responses to an oral glucose tolerance test and fasting triglyceride concentrations.Results In fully confounder-adjusted models, mean (95% CI) concentrations of fasting glucose, insulin, and triglycerides were slightly higher on Mondays compared with the other weekdays [glucose: 1% (0-2); insulin: 9% (1-18); triglycerides: 5% (2-8)]. Interaction analyses revealed that the association of weekday with insulin was only pronounced in men [18% (3-35)], but not in women [1% (-8-10)], whereas the associations with glucose and triglycerides were only apparent for individuals with known type 2 diabetes [glucose: 4% (0-7); triglycerides: 14% (6-23)] compared to the background population [glucose: 0% (0-1); triglycerides: 3% (0-6)].Discussion Being examined on a Monday was associated with higher fasting insulin concentrations among men but not women.

AB - Context: The timing of sleep, physical activity, and dietary intake show variation over the week, with different timings in the weekend compared to the weekdays, which may potentially lead to impaired glucose and lipid regulation on Mondays compared to other weekdays.Objective The aim of the study was to investigate differences in glucose metabolism and fasting triglyceride concentrations on Mondays compared to the rest of the week.Design, setting and participants This cross-sectional study is based on data from the Maastricht Study, including 6067 participants without known diabetes and 1568 previously diagnosed with type 2 diabetes.Main outcome measures Confounder-adjusted linear regression analysis was applied to study the associations of day of the week of examination with glucose and insulin responses to an oral glucose tolerance test and fasting triglyceride concentrations.Results In fully confounder-adjusted models, mean (95% CI) concentrations of fasting glucose, insulin, and triglycerides were slightly higher on Mondays compared with the other weekdays [glucose: 1% (0-2); insulin: 9% (1-18); triglycerides: 5% (2-8)]. Interaction analyses revealed that the association of weekday with insulin was only pronounced in men [18% (3-35)], but not in women [1% (-8-10)], whereas the associations with glucose and triglycerides were only apparent for individuals with known type 2 diabetes [glucose: 4% (0-7); triglycerides: 14% (6-23)] compared to the background population [glucose: 0% (0-1); triglycerides: 3% (0-6)].Discussion Being examined on a Monday was associated with higher fasting insulin concentrations among men but not women.

KW - metabolism

KW - triglyceride

KW - weekday

KW - oral glucose tolerance test

KW - SOCIAL JETLAG

KW - DIET

KW - ASSOCIATION

KW - SOCIETY

KW - HEALTH

U2 - 10.1210/clinem/dgac286

DO - 10.1210/clinem/dgac286

M3 - Journal article

C2 - 35575196

VL - 107

SP - e3145–e3151

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 8

ER -