Role of Mannose-binding Lectin and Association with Microbial Sensitization in a Cohort of Patients with Atopic Dermatitis

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Role of Mannose-binding Lectin and Association with Microbial Sensitization in a Cohort of Patients with Atopic Dermatitis. / Belfrage, Emma; Jinnestål, Camilla L.; Jönsen, Andreas; Bengtsson, Anders; Åkesson, Anna; Schmidtchen, Artur; Sonesson, Andreas.

In: Acta Dermato-Venereologica, Vol. 103, adv2405, 2023.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Belfrage, E, Jinnestål, CL, Jönsen, A, Bengtsson, A, Åkesson, A, Schmidtchen, A & Sonesson, A 2023, 'Role of Mannose-binding Lectin and Association with Microbial Sensitization in a Cohort of Patients with Atopic Dermatitis', Acta Dermato-Venereologica, vol. 103, adv2405. https://doi.org/10.2340/actadv.v103.2405

APA

Belfrage, E., Jinnestål, C. L., Jönsen, A., Bengtsson, A., Åkesson, A., Schmidtchen, A., & Sonesson, A. (2023). Role of Mannose-binding Lectin and Association with Microbial Sensitization in a Cohort of Patients with Atopic Dermatitis. Acta Dermato-Venereologica, 103, [adv2405]. https://doi.org/10.2340/actadv.v103.2405

Vancouver

Belfrage E, Jinnestål CL, Jönsen A, Bengtsson A, Åkesson A, Schmidtchen A et al. Role of Mannose-binding Lectin and Association with Microbial Sensitization in a Cohort of Patients with Atopic Dermatitis. Acta Dermato-Venereologica. 2023;103. adv2405. https://doi.org/10.2340/actadv.v103.2405

Author

Belfrage, Emma ; Jinnestål, Camilla L. ; Jönsen, Andreas ; Bengtsson, Anders ; Åkesson, Anna ; Schmidtchen, Artur ; Sonesson, Andreas. / Role of Mannose-binding Lectin and Association with Microbial Sensitization in a Cohort of Patients with Atopic Dermatitis. In: Acta Dermato-Venereologica. 2023 ; Vol. 103.

Bibtex

@article{19a23de1f3e047fa8e256392d5744da2,
title = "Role of Mannose-binding Lectin and Association with Microbial Sensitization in a Cohort of Patients with Atopic Dermatitis",
abstract = "Atopic dermatitis is a relapsing inflammatory skin condition, in which bacteria, fungi and viruses may colonize the skin and aggravate the condition. Mannose-binding lectin is part of the innate immune system. Polymorphism in the mannose-binding lectin gene can result in deficiency of mannose-binding lectin, which may affect defence against microbes. The aim of this study was to investigate whether polymorphisms in the mannose-binding lectin gene affect the extent of sensitization to common skin microbes, the skin barrier function, or the severity of the disease in a cohort of patients with atopic dermatitis. Genetic testing of mannose-binding lectin polymorphism was performed in 60 patients with atopic dermatitis. The disease severity, skin barrier function, and serum levels of specific immunoglobulin E against skin microbes were measured. In patients with low mannose-binding lectin genotype (group 1) 6 of 8 (75%) were sensitized to Candida albicans, compared to 14 of 22 (63.6%) patients with intermediate mannose-binding genotype  (group 2) and 10 of 30 (33.3%) patients with high mannose-binding genotype (group 3). Group 1 (low mannose-binding lectin) was more likely to be sensitized to Candida albicans compared with group 3 (high mannose-binding lectin) (odds ratio 6.34, p-value 0.045). In this cohort of patients with atopic dermatitis, mannose-binding lectin deficiency was associated with increased sensitization to Candida albicans.",
author = "Emma Belfrage and Jinnest{\aa}l, {Camilla L.} and Andreas J{\"o}nsen and Anders Bengtsson and Anna {\AA}kesson and Artur Schmidtchen and Andreas Sonesson",
year = "2023",
doi = "10.2340/actadv.v103.2405",
language = "English",
volume = "103",
journal = "Acta Dermato-Venereologica",
issn = "0001-5555",
publisher = "Society for the Publication of Acta Dermato - Venereologica",

}

RIS

TY - JOUR

T1 - Role of Mannose-binding Lectin and Association with Microbial Sensitization in a Cohort of Patients with Atopic Dermatitis

AU - Belfrage, Emma

AU - Jinnestål, Camilla L.

AU - Jönsen, Andreas

AU - Bengtsson, Anders

AU - Åkesson, Anna

AU - Schmidtchen, Artur

AU - Sonesson, Andreas

PY - 2023

Y1 - 2023

N2 - Atopic dermatitis is a relapsing inflammatory skin condition, in which bacteria, fungi and viruses may colonize the skin and aggravate the condition. Mannose-binding lectin is part of the innate immune system. Polymorphism in the mannose-binding lectin gene can result in deficiency of mannose-binding lectin, which may affect defence against microbes. The aim of this study was to investigate whether polymorphisms in the mannose-binding lectin gene affect the extent of sensitization to common skin microbes, the skin barrier function, or the severity of the disease in a cohort of patients with atopic dermatitis. Genetic testing of mannose-binding lectin polymorphism was performed in 60 patients with atopic dermatitis. The disease severity, skin barrier function, and serum levels of specific immunoglobulin E against skin microbes were measured. In patients with low mannose-binding lectin genotype (group 1) 6 of 8 (75%) were sensitized to Candida albicans, compared to 14 of 22 (63.6%) patients with intermediate mannose-binding genotype  (group 2) and 10 of 30 (33.3%) patients with high mannose-binding genotype (group 3). Group 1 (low mannose-binding lectin) was more likely to be sensitized to Candida albicans compared with group 3 (high mannose-binding lectin) (odds ratio 6.34, p-value 0.045). In this cohort of patients with atopic dermatitis, mannose-binding lectin deficiency was associated with increased sensitization to Candida albicans.

AB - Atopic dermatitis is a relapsing inflammatory skin condition, in which bacteria, fungi and viruses may colonize the skin and aggravate the condition. Mannose-binding lectin is part of the innate immune system. Polymorphism in the mannose-binding lectin gene can result in deficiency of mannose-binding lectin, which may affect defence against microbes. The aim of this study was to investigate whether polymorphisms in the mannose-binding lectin gene affect the extent of sensitization to common skin microbes, the skin barrier function, or the severity of the disease in a cohort of patients with atopic dermatitis. Genetic testing of mannose-binding lectin polymorphism was performed in 60 patients with atopic dermatitis. The disease severity, skin barrier function, and serum levels of specific immunoglobulin E against skin microbes were measured. In patients with low mannose-binding lectin genotype (group 1) 6 of 8 (75%) were sensitized to Candida albicans, compared to 14 of 22 (63.6%) patients with intermediate mannose-binding genotype  (group 2) and 10 of 30 (33.3%) patients with high mannose-binding genotype (group 3). Group 1 (low mannose-binding lectin) was more likely to be sensitized to Candida albicans compared with group 3 (high mannose-binding lectin) (odds ratio 6.34, p-value 0.045). In this cohort of patients with atopic dermatitis, mannose-binding lectin deficiency was associated with increased sensitization to Candida albicans.

UR - http://www.scopus.com/inward/record.url?scp=85151228805&partnerID=8YFLogxK

U2 - 10.2340/actadv.v103.2405

DO - 10.2340/actadv.v103.2405

M3 - Journal article

C2 - 36994777

AN - SCOPUS:85151228805

VL - 103

JO - Acta Dermato-Venereologica

JF - Acta Dermato-Venereologica

SN - 0001-5555

M1 - adv2405

ER -

ID: 342612128