Rho GTPase function in tumorigenesis

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Rho GTPase function in tumorigenesis. / Karlsson, R; Pedersen, Esben Ditlev Kølle; Wang, Zhipeng; Brakebusch, Cord.

In: BBA General Subjects, 2009.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Karlsson, R, Pedersen, EDK, Wang, Z & Brakebusch, C 2009, 'Rho GTPase function in tumorigenesis', BBA General Subjects. https://doi.org/10.1016/j.bbcan.2009.03.003

APA

Karlsson, R., Pedersen, E. D. K., Wang, Z., & Brakebusch, C. (2009). Rho GTPase function in tumorigenesis. BBA General Subjects. https://doi.org/10.1016/j.bbcan.2009.03.003

Vancouver

Karlsson R, Pedersen EDK, Wang Z, Brakebusch C. Rho GTPase function in tumorigenesis. BBA General Subjects. 2009. https://doi.org/10.1016/j.bbcan.2009.03.003

Author

Karlsson, R ; Pedersen, Esben Ditlev Kølle ; Wang, Zhipeng ; Brakebusch, Cord. / Rho GTPase function in tumorigenesis. In: BBA General Subjects. 2009.

Bibtex

@article{a7413cb0625b11de8bc9000ea68e967b,
title = "Rho GTPase function in tumorigenesis",
abstract = "Malignant tumor cells display uncontrolled proliferation, loss of epithelial cell polarity, altered interactions with neighboring cells and the surrounding extracellular matrix, and enhanced migratory properties. Proteins of the Rho GTPase family regulate all these processes in cell culture and, for that reason, Rho GTPases, their regulators, and their effectors have been suggested to control tumor formation and progression in humans. However, while the tumor-relevant functions of Rho GTPases are very well documented in vitro, we are only now beginning to assess their contribution to cancer in human patients and in animal models. This review will give a very brief overview of Rho GTPase function in general and then focus on in vivo evidence for a role of Rho GTPases in malignant tumors, both in human patients and in genetically modified mice.",
author = "R Karlsson and Pedersen, {Esben Ditlev K{\o}lle} and Zhipeng Wang and Cord Brakebusch",
year = "2009",
doi = "10.1016/j.bbcan.2009.03.003",
language = "English",
journal = "B B A - General Subjects",
issn = "0304-4165",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Rho GTPase function in tumorigenesis

AU - Karlsson, R

AU - Pedersen, Esben Ditlev Kølle

AU - Wang, Zhipeng

AU - Brakebusch, Cord

PY - 2009

Y1 - 2009

N2 - Malignant tumor cells display uncontrolled proliferation, loss of epithelial cell polarity, altered interactions with neighboring cells and the surrounding extracellular matrix, and enhanced migratory properties. Proteins of the Rho GTPase family regulate all these processes in cell culture and, for that reason, Rho GTPases, their regulators, and their effectors have been suggested to control tumor formation and progression in humans. However, while the tumor-relevant functions of Rho GTPases are very well documented in vitro, we are only now beginning to assess their contribution to cancer in human patients and in animal models. This review will give a very brief overview of Rho GTPase function in general and then focus on in vivo evidence for a role of Rho GTPases in malignant tumors, both in human patients and in genetically modified mice.

AB - Malignant tumor cells display uncontrolled proliferation, loss of epithelial cell polarity, altered interactions with neighboring cells and the surrounding extracellular matrix, and enhanced migratory properties. Proteins of the Rho GTPase family regulate all these processes in cell culture and, for that reason, Rho GTPases, their regulators, and their effectors have been suggested to control tumor formation and progression in humans. However, while the tumor-relevant functions of Rho GTPases are very well documented in vitro, we are only now beginning to assess their contribution to cancer in human patients and in animal models. This review will give a very brief overview of Rho GTPase function in general and then focus on in vivo evidence for a role of Rho GTPases in malignant tumors, both in human patients and in genetically modified mice.

U2 - 10.1016/j.bbcan.2009.03.003

DO - 10.1016/j.bbcan.2009.03.003

M3 - Journal article

C2 - 19327386

JO - B B A - General Subjects

JF - B B A - General Subjects

SN - 0304-4165

ER -

ID: 12866297