Renal tubular function in patients treated with high-dose cisplatin.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Renal tubular function in patients treated with high-dose cisplatin. / Daugaard, G; Abildgaard, U; Holstein-Rathlou, N H; Bruunshuus, I; Bucher, D; Leyssac, P P.

In: Clinical Pharmacology and Therapeutics, Vol. 44, No. 2, 1988, p. 164-72.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Daugaard, G, Abildgaard, U, Holstein-Rathlou, NH, Bruunshuus, I, Bucher, D & Leyssac, PP 1988, 'Renal tubular function in patients treated with high-dose cisplatin.', Clinical Pharmacology and Therapeutics, vol. 44, no. 2, pp. 164-72.

APA

Daugaard, G., Abildgaard, U., Holstein-Rathlou, N. H., Bruunshuus, I., Bucher, D., & Leyssac, P. P. (1988). Renal tubular function in patients treated with high-dose cisplatin. Clinical Pharmacology and Therapeutics, 44(2), 164-72.

Vancouver

Daugaard G, Abildgaard U, Holstein-Rathlou NH, Bruunshuus I, Bucher D, Leyssac PP. Renal tubular function in patients treated with high-dose cisplatin. Clinical Pharmacology and Therapeutics. 1988;44(2):164-72.

Author

Daugaard, G ; Abildgaard, U ; Holstein-Rathlou, N H ; Bruunshuus, I ; Bucher, D ; Leyssac, P P. / Renal tubular function in patients treated with high-dose cisplatin. In: Clinical Pharmacology and Therapeutics. 1988 ; Vol. 44, No. 2. pp. 164-72.

Bibtex

@article{76159e30abed11ddb5e9000ea68e967b,
title = "Renal tubular function in patients treated with high-dose cisplatin.",
abstract = "The effect of three cycles of high-dose cisplatin (40 mg/m2 day for 5 days) on renal tubular function was evaluated in 30 patients. A significant impairment of proximal tubular salt and water reabsorption rates was observed, but also distal tubular function seemed to be affected. These changes were also present 6 months after termination of treatment. Sodium and magnesium clearance increased significantly during treatment. Magnesium clearance normalized shortly after treatment but sodium clearance was significantly elevated 6 months after treatment. Proteinuria, albuminuria, and amino aciduria, together with an increase of beta 2-microglobulin and N-acetyl-beta-D-glucosaminidase (NAG) excretion rates, were observed during each treatment cycle. A good correlation was registered between the increase in urinary excretion rates of protein, NAG, and magnesium and the decrease in proximal tubular salt and water reabsorption during cisplatin administration.",
author = "G Daugaard and U Abildgaard and Holstein-Rathlou, {N H} and I Bruunshuus and D Bucher and Leyssac, {P P}",
note = "Keywords: Acetylglucosaminidase; Adolescent; Adult; Albuminuria; Amino Acids; Cisplatin; Humans; Kidney Function Tests; Kidney Tubules; Kidney Tubules, Distal; Kidney Tubules, Proximal; Magnesium; Middle Aged; Neoplasms, Germ Cell and Embryonal; Proteinuria; Sodium; Time Factors; beta 2-Microglobulin",
year = "1988",
language = "English",
volume = "44",
pages = "164--72",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "JohnWiley & Sons, Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Renal tubular function in patients treated with high-dose cisplatin.

AU - Daugaard, G

AU - Abildgaard, U

AU - Holstein-Rathlou, N H

AU - Bruunshuus, I

AU - Bucher, D

AU - Leyssac, P P

N1 - Keywords: Acetylglucosaminidase; Adolescent; Adult; Albuminuria; Amino Acids; Cisplatin; Humans; Kidney Function Tests; Kidney Tubules; Kidney Tubules, Distal; Kidney Tubules, Proximal; Magnesium; Middle Aged; Neoplasms, Germ Cell and Embryonal; Proteinuria; Sodium; Time Factors; beta 2-Microglobulin

PY - 1988

Y1 - 1988

N2 - The effect of three cycles of high-dose cisplatin (40 mg/m2 day for 5 days) on renal tubular function was evaluated in 30 patients. A significant impairment of proximal tubular salt and water reabsorption rates was observed, but also distal tubular function seemed to be affected. These changes were also present 6 months after termination of treatment. Sodium and magnesium clearance increased significantly during treatment. Magnesium clearance normalized shortly after treatment but sodium clearance was significantly elevated 6 months after treatment. Proteinuria, albuminuria, and amino aciduria, together with an increase of beta 2-microglobulin and N-acetyl-beta-D-glucosaminidase (NAG) excretion rates, were observed during each treatment cycle. A good correlation was registered between the increase in urinary excretion rates of protein, NAG, and magnesium and the decrease in proximal tubular salt and water reabsorption during cisplatin administration.

AB - The effect of three cycles of high-dose cisplatin (40 mg/m2 day for 5 days) on renal tubular function was evaluated in 30 patients. A significant impairment of proximal tubular salt and water reabsorption rates was observed, but also distal tubular function seemed to be affected. These changes were also present 6 months after termination of treatment. Sodium and magnesium clearance increased significantly during treatment. Magnesium clearance normalized shortly after treatment but sodium clearance was significantly elevated 6 months after treatment. Proteinuria, albuminuria, and amino aciduria, together with an increase of beta 2-microglobulin and N-acetyl-beta-D-glucosaminidase (NAG) excretion rates, were observed during each treatment cycle. A good correlation was registered between the increase in urinary excretion rates of protein, NAG, and magnesium and the decrease in proximal tubular salt and water reabsorption during cisplatin administration.

M3 - Journal article

C2 - 2840230

VL - 44

SP - 164

EP - 172

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

SN - 0009-9236

IS - 2

ER -

ID: 8440126