Reduction in atrial and pulmonary vein stretch as a therapeutic target for prevention of atrial fibrillation

Research output: Contribution to journal › Review › Research › peer-review

Standard

Reduction in atrial and pulmonary vein stretch as a therapeutic target for prevention of atrial fibrillation. / Gottlieb, Lisa A; Coronel, Ruben; Dekker, Lukas R C.

In: Heart Rhythm, Vol. 20, No. 2, 2023, p. 291-298.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Gottlieb, LA, Coronel, R & Dekker, LRC 2023, 'Reduction in atrial and pulmonary vein stretch as a therapeutic target for prevention of atrial fibrillation', Heart Rhythm, vol. 20, no. 2, pp. 291-298. https://doi.org/10.1016/j.hrthm.2022.10.009

APA

Gottlieb, L. A., Coronel, R., & Dekker, L. R. C. (2023). Reduction in atrial and pulmonary vein stretch as a therapeutic target for prevention of atrial fibrillation. Heart Rhythm, 20(2), 291-298. https://doi.org/10.1016/j.hrthm.2022.10.009

Vancouver

Gottlieb LA, Coronel R, Dekker LRC. Reduction in atrial and pulmonary vein stretch as a therapeutic target for prevention of atrial fibrillation. Heart Rhythm. 2023;20(2):291-298. https://doi.org/10.1016/j.hrthm.2022.10.009

Author

Gottlieb, Lisa A ; Coronel, Ruben ; Dekker, Lukas R C. / Reduction in atrial and pulmonary vein stretch as a therapeutic target for prevention of atrial fibrillation. In: Heart Rhythm. 2023 ; Vol. 20, No. 2. pp. 291-298.

Bibtex

@article{45c76d0a5ea34a53a34015bef5f17b77,
title = "Reduction in atrial and pulmonary vein stretch as a therapeutic target for prevention of atrial fibrillation",
abstract = "Atrial fibrillation (AF) is a common cardiac arrhythmia that is associated with increased mortality. Heart failure, hypertension, valvular disease, and obstructive sleep apnea are risk factors for incident AF. A common characteristic of these diseases is that they increase atrial wall stretch. Multiple experimental studies confirm a proarrhythmic effect of atrial stretch. Conversely, a reduction in stretch is antiarrhythmic. A therapeutic target for AF, therefore, lies in local reduction of atrial stretch. This review focuses on atrial stretch and its clinical associations in patients with AF and its downstream effects on electrophysiology. We discuss the possible application of targeted atrial stretch reduction in AF prevention. We conclude that a reduction in local atrial stretch should be considered an essential element in rhythm control.",
keywords = "Humans, Atrial Fibrillation/therapy, Pulmonary Veins/surgery, Heart Atria, Anti-Arrhythmia Agents/therapeutic use, Risk Factors, Catheter Ablation/adverse effects, Treatment Outcome",
author = "Gottlieb, {Lisa A} and Ruben Coronel and Dekker, {Lukas R C}",
note = "Copyright {\textcopyright} 2022 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.",
year = "2023",
doi = "10.1016/j.hrthm.2022.10.009",
language = "English",
volume = "20",
pages = "291--298",
journal = "Heart Rhythm",
issn = "1547-5271",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Reduction in atrial and pulmonary vein stretch as a therapeutic target for prevention of atrial fibrillation

AU - Gottlieb, Lisa A

AU - Coronel, Ruben

AU - Dekker, Lukas R C

N1 - Copyright © 2022 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

PY - 2023

Y1 - 2023

N2 - Atrial fibrillation (AF) is a common cardiac arrhythmia that is associated with increased mortality. Heart failure, hypertension, valvular disease, and obstructive sleep apnea are risk factors for incident AF. A common characteristic of these diseases is that they increase atrial wall stretch. Multiple experimental studies confirm a proarrhythmic effect of atrial stretch. Conversely, a reduction in stretch is antiarrhythmic. A therapeutic target for AF, therefore, lies in local reduction of atrial stretch. This review focuses on atrial stretch and its clinical associations in patients with AF and its downstream effects on electrophysiology. We discuss the possible application of targeted atrial stretch reduction in AF prevention. We conclude that a reduction in local atrial stretch should be considered an essential element in rhythm control.

AB - Atrial fibrillation (AF) is a common cardiac arrhythmia that is associated with increased mortality. Heart failure, hypertension, valvular disease, and obstructive sleep apnea are risk factors for incident AF. A common characteristic of these diseases is that they increase atrial wall stretch. Multiple experimental studies confirm a proarrhythmic effect of atrial stretch. Conversely, a reduction in stretch is antiarrhythmic. A therapeutic target for AF, therefore, lies in local reduction of atrial stretch. This review focuses on atrial stretch and its clinical associations in patients with AF and its downstream effects on electrophysiology. We discuss the possible application of targeted atrial stretch reduction in AF prevention. We conclude that a reduction in local atrial stretch should be considered an essential element in rhythm control.

KW - Humans

KW - Atrial Fibrillation/therapy

KW - Pulmonary Veins/surgery

KW - Heart Atria

KW - Anti-Arrhythmia Agents/therapeutic use

KW - Risk Factors

KW - Catheter Ablation/adverse effects

KW - Treatment Outcome

U2 - 10.1016/j.hrthm.2022.10.009

DO - 10.1016/j.hrthm.2022.10.009

M3 - Review

C2 - 36265692

VL - 20

SP - 291

EP - 298

JO - Heart Rhythm

JF - Heart Rhythm

SN - 1547-5271

IS - 2

ER -

ID: 396849913