Reduced levels of pulmonary surfactant in COVID-19 ARDS
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To provide novel data on surfactant levels in adult COVID-19 patients, we collected bronchoalveolar lavage fluid less than 72 h after intubation and used Fourier Transform Infrared Spectroscopy to measure levels of dipalmitoylphosphatidylcholine (DPPC). A total of eleven COVID-19 patients with moderate-to-severe ARDS (CARDS) and 15 healthy controls were included. CARDS patients had lower DPPC levels than healthy controls. Moreover, a principal component analysis was able to separate patient groups into distinguishable subgroups. Our findings indicate markedly impaired pulmonary surfactant levels in COVID-19 patients, justifying further studies and clinical trials of exogenous surfactant.
Original language | English |
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Article number | 4040 |
Journal | Scientific Reports |
Volume | 12 |
Issue number | 1 |
Number of pages | 5 |
ISSN | 2045-2322 |
DOIs | |
Publication status | Published - 2022 |
Bibliographical note
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© 2022, The Author(s).
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