Recovery of Cardiac Function Following COVID-19 - ECHOVID-19: A Prospective Longitudinal Cohort Study
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Recovery of Cardiac Function Following COVID-19 - ECHOVID-19 : A Prospective Longitudinal Cohort Study. / Lassen, Mats Christian Højbjerg; Skaarup, Kristoffer Grundtvig; Lind, Jannie Nørgaard; Alhakak, Alia Saed; Sengeløv, Morten; Nielsen, Anne Bjerg; Simonsen, Jakob Øystein; Johansen, Niklas Dyrby; Davidovski, Filip Søskov; Christensen, Jacob; Bundgaard, Henning; Hassager, Christian; Jabbari, Reza; Carlsen, Jørn; Kirk, Ole; Lindholm, Matias Greve; Kristiansen, Ole Peter; Nielsen, Olav Wendelboe; Ulrik, Charlotte Suppli; Sivapalan, Pradeesh; Gislason, Gunnar; Møgelvang, Rasmus; Jensen, Gorm Boje; Schnohr, Peter; Søgaard, Peter; Solomon, Scott D.; Iversen, Kasper; Jensen, Jens Ulrik Stæhr; Schou, Morten; Biering-Sørensen, Tor.
In: European Journal of Heart Failure, Vol. 23, No. 11, 2021, p. 1903-1912.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Recovery of Cardiac Function Following COVID-19 - ECHOVID-19
T2 - A Prospective Longitudinal Cohort Study
AU - Lassen, Mats Christian Højbjerg
AU - Skaarup, Kristoffer Grundtvig
AU - Lind, Jannie Nørgaard
AU - Alhakak, Alia Saed
AU - Sengeløv, Morten
AU - Nielsen, Anne Bjerg
AU - Simonsen, Jakob Øystein
AU - Johansen, Niklas Dyrby
AU - Davidovski, Filip Søskov
AU - Christensen, Jacob
AU - Bundgaard, Henning
AU - Hassager, Christian
AU - Jabbari, Reza
AU - Carlsen, Jørn
AU - Kirk, Ole
AU - Lindholm, Matias Greve
AU - Kristiansen, Ole Peter
AU - Nielsen, Olav Wendelboe
AU - Ulrik, Charlotte Suppli
AU - Sivapalan, Pradeesh
AU - Gislason, Gunnar
AU - Møgelvang, Rasmus
AU - Jensen, Gorm Boje
AU - Schnohr, Peter
AU - Søgaard, Peter
AU - Solomon, Scott D.
AU - Iversen, Kasper
AU - Jensen, Jens Ulrik Stæhr
AU - Schou, Morten
AU - Biering-Sørensen, Tor
PY - 2021
Y1 - 2021
N2 - AimsThe degree of cardiovascular sequelae following COVID-19 remains unknown. The aim of this study was to investigate whether cardiac function recovers following COVID-19.Methods and resultsA consecutive sample of patients hospitalized with COVID-19 was prospectively included in this longitudinal study. All patients underwent an echocardiographic examination during hospitalization and 2 months later. All participants were successfully matched 1:1 with COVID-19-free controls by age and sex. A total of 91 patients were included (mean age 63 ± 12 years, 59% male). A median of 77 days (interquartile range: 72–92) passed between the two examinations. Right ventricular (RV) function improved following resolution of COVID-19: tricuspid annular plane systolic excursion (TAPSE) (2.28 ± 0.40 cm vs. 2.11 ± 0.38 cm, P < 0.001) and RV longitudinal strain (RVLS) (25.3 ± 5.5% vs. 19.9 ± 5.8%, P < 0.001). In contrast, left ventricular (LV) systolic function assessed by global longitudinal strain (GLS) did not significantly improve (17.4 ± 2.9% vs. 17.6 ± 3.3%, P = 0.6). N-terminal pro-B-type natriuretic peptide decreased between the two examinations [177.6 (80.3–408.0) ng/L vs. 11.7 (5.7–24.0) ng/L, P < 0.001]. None of the participants had elevated troponins at follow-up compared to 18 (27.7%) during hospitalization. Recovered COVID-19 patients had significantly lower GLS (17.4 ± 2.9% vs. 18.8 ± 2.9%, P < 0.001 and adjusted P = 0.004), TAPSE (2.28 ± 0.40 cm vs. 2.67 ± 0.44 cm, P < 0.001 and adjusted P < 0.001), and RVLS (25.3 ± 5.5% vs. 26.6 ± 5.8%, P = 0.50 and adjusted P < 0.001) compared to matched controls.ConclusionAcute COVID-19 affected negatively RV function and cardiac biomarkers but recovered following resolution of COVID-19. In contrast, the observed reduced LV function during acute COVID-19 did not improve post-COVID-19. Compared to the matched controls, both LV and RV function remained impaired.
AB - AimsThe degree of cardiovascular sequelae following COVID-19 remains unknown. The aim of this study was to investigate whether cardiac function recovers following COVID-19.Methods and resultsA consecutive sample of patients hospitalized with COVID-19 was prospectively included in this longitudinal study. All patients underwent an echocardiographic examination during hospitalization and 2 months later. All participants were successfully matched 1:1 with COVID-19-free controls by age and sex. A total of 91 patients were included (mean age 63 ± 12 years, 59% male). A median of 77 days (interquartile range: 72–92) passed between the two examinations. Right ventricular (RV) function improved following resolution of COVID-19: tricuspid annular plane systolic excursion (TAPSE) (2.28 ± 0.40 cm vs. 2.11 ± 0.38 cm, P < 0.001) and RV longitudinal strain (RVLS) (25.3 ± 5.5% vs. 19.9 ± 5.8%, P < 0.001). In contrast, left ventricular (LV) systolic function assessed by global longitudinal strain (GLS) did not significantly improve (17.4 ± 2.9% vs. 17.6 ± 3.3%, P = 0.6). N-terminal pro-B-type natriuretic peptide decreased between the two examinations [177.6 (80.3–408.0) ng/L vs. 11.7 (5.7–24.0) ng/L, P < 0.001]. None of the participants had elevated troponins at follow-up compared to 18 (27.7%) during hospitalization. Recovered COVID-19 patients had significantly lower GLS (17.4 ± 2.9% vs. 18.8 ± 2.9%, P < 0.001 and adjusted P = 0.004), TAPSE (2.28 ± 0.40 cm vs. 2.67 ± 0.44 cm, P < 0.001 and adjusted P < 0.001), and RVLS (25.3 ± 5.5% vs. 26.6 ± 5.8%, P = 0.50 and adjusted P < 0.001) compared to matched controls.ConclusionAcute COVID-19 affected negatively RV function and cardiac biomarkers but recovered following resolution of COVID-19. In contrast, the observed reduced LV function during acute COVID-19 did not improve post-COVID-19. Compared to the matched controls, both LV and RV function remained impaired.
KW - COVID-19
KW - follow-up
KW - recovery following COVID-19
KW - strain echocardiography
KW - COVID-19
KW - follow-up
KW - recovery following COVID-19
KW - strain echocardiography
U2 - 10.1002/ejhf.2347
DO - 10.1002/ejhf.2347
M3 - Journal article
C2 - 34514713
VL - 23
SP - 1903
EP - 1912
JO - European Journal of Heart Failure
JF - European Journal of Heart Failure
SN - 1567-4215
IS - 11
ER -
ID: 279649403